Gingival crevicular fluid galectin-3 and interleukin-1 beta levels in stage 3 periodontitis with grade B and C

ObjectivesThis study aims to evaluate GCF Galectin-3 and Interleukin-1 beta (IL-beta) levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in periodontal diseases.Materials and methodsA total of 80 systemically healthy and non-smoker individuals, 20 stage 3 grade C (S3GC) periodontitis 20 stage 3 grade B (S3GB) periodontitis, 20 gingivitis, and 20 periodontally healthy were enrolled. Clinical periodontal parameters were recorded and GCF Galectin-3 and IL-1 beta total amounts were measured by ELISA. Receiver operating characteristics curve was used for estimating the area under the curve (AUC).ResultsGalectin-3 and IL-1 beta were detected in all participants. Both periodontitis groups had significantly higher GCF Galectin-3 total amounts than periodontally healthy controls (p <0.05). S3GC periodontitis group had also significantly higher GCF Galectin-3 levels than gingivitis group (p <0.05). GCF IL-1 beta levels in periodontitis groups were higher than gingivitis and periodontally healthy groups (p <0.05). Galectin-3 exhibited an AUC value of 0.89 with 95% sensitivity to discriminate S3GC periodontitis from periodontal health, an AUC value of 0.87 with 80% sensitivity to discriminate S3GC periodontitis versus gingivitis, while an AUC value of 0.85 with 95% sensitivity to discriminate S3GB periodontitis from healthy controls.ConclusionsGCF Galectin-3 levels are involved in the pathogenesis of periodontal diseases. Galectin-3 showed excellent diagnostic performances to discriminate S3GB and S3GC periodontitis from periodontal health and gingivitis.

Automated summary

This study aims to evaluate the levels of GCF Galectin-3 and IL-1 beta in different grades of stage 3 periodontitis and investigate their efficiency in discriminating periodontal diseases. ELISA was used to measure the total amounts of GCF Galectin-3 and IL-1 beta in 80 individuals. The results showed that GCF Galectin-3 is associated with the pathogenesis of periodontal diseases and has high diagnostic performance.