期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2016.00151
关键词
behavior; gender differences; mouse model; autism; schizophrenia; PSD-95
资金
- Innovative Medicines Initiative Joint Undertaking [115300]
- European Union's Seventh Framework Programme
- Max Planck Society
- German Research Foundation (DFG)
- German Research Foundation (CNMPB)
- German Research Foundation (HE)
- Alexander von Humboldt Foundation
- European Commission (International Reintegration Grant) [PIRG07-GA-2010-268358]
- FAPESP (Research Internship Abroad (BEPE) [2014/18795-2]
Impairments in social skills are central to mental disease, and developing tools for their assessment in mouse models is essential. Here we present the SocioBox, a new behavioral paradigm to measure social recognition. Using this paradigm, we show that male wildtype mice of different strains can readily identify an unfamiliar mouse among 5 newly acquainted animals. In contrast, female mice exhibit lower locomotor activity during social exploration in the SocioBox compared to males and do not seem to discriminate between acquainted and unfamiliar mice, likely reflecting inherent differences in gender-specific territorial tasks. In addition to a simple quantification of social interaction time of mice grounded on predefined spatial zones (zone-based method), we developed a set of unbiased, data-driven analysis tools based on heat map representations and characterized by greater sensitivity. First proof-of-principle that the SocioBox allows diagnosis of social recognition deficits is provided using male PSD-95 heterozygous knockout mice, a mouse model related to psychiatric pathophysiology.
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