期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2016.00171
关键词
anxiety; stress; local field potentials; ventral hippocampus; amygdala; prefrontal cortex
资金
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/40459/2007]
- CCDR-N [UMINHO/BPD/27/2013]
- Fundacao Calouste Gulbenkian funded project [UMINHO/BPD/63/2015, P-139977]
- FEDER funds through the Operational Programme Competitiveness Factors - COMPETE
- National Funds through FCT [ECOMP-01-0124-FEDER-021145, FCT/PTDC/SAU-ENB/118383/2010, FCOMP-01-0124-FEDER-022674, POCI-01-0145-FEDER-007038]
- Norte Portugal Regional Operational Programme (NORTE), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000013]
- Programa Operational Regiao Norte (ON.2) from QREN/FEDER
- Fundação para a Ciência e a Tecnologia [SFRH/BD/40459/2007] Funding Source: FCT
Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (FPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA), and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA, and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response.
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