Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients

Solid organ transplant recipients (SOTR) frequently report tremor. Data concerning tremor-related impairment and its potential impact on health-related quality of life (HRQoL) are lacking. This cross-sectional study assesses impact of tremor on activities of daily living and HRQoL using validated questionnaires among SOTR enrolled in the TransplantLines Biobank and Cohort Study. We included 689 SOTR (38.5% female, mean [+/- SD] age 58 [+/- 14] years) at median [interquartile range] 3 [1-9] years after transplantation, of which 287 (41.7%) reported mild or severe tremor. In multinomial logistic regression analyses, whole blood tacrolimus trough concentration was an independent determinant of mild tremor (OR per mu g/L increase: 1.11, 95% CI: 1.02 to 1.21, p = 0.019). Furthermore, in linear regression analyses, severe tremor was strongly and independently associated with lower physical and mental HRQoL (beta = -16.10, 95% CI: -22.23 to -9.98, p < 0.001 and beta = -12.68, 95% CI: -18.23 to -7.14, p < 0.001 resp.). SOTR frequently report tremor-related impairment of activities of daily living. Tacrolimus trough concentrations appeared as a main determinant of tremor among SOTR. The strong and independent association of tremor-related impairment with lower HRQoL warrants further studies into the effects of tacrolimus on tremor.

Automated summary

Solid organ transplant recipients frequently experience tremor, and this study investigates the impact of tremor on activities of daily living and health-related quality of life (HRQoL). Results show that whole blood tacrolimus trough concentration is an independent determinant of mild tremor among these recipients. Severe tremor is strongly associated with lower physical and mental HRQoL. These findings emphasize the need for further research on the effects of tacrolimus on tremor.