Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive malignancy with high mortality involving the skin and hematopoietic system. Clinical suspicion is difficult, and management of skin lesions is challenging due to their indolent course prior to dissemination. We describe a patient with isolated skin involvement who progressed to CD4+/CD56+ and CD123+ acute leukemia.

Automated summary

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive malignancy that affects the skin and hematopoietic system. It is difficult to clinically suspect, and managing skin lesions is challenging due to their slow progression before spreading. We present a case of a patient with isolated skin involvement who later developed CD4+/CD56+ and CD123+ acute leukemia.