We present an efficient one-pot, two-step synthesis of a-difunctionalized alkynes and trisubstituted allenes by using benzal gem-diacetates and organozinc or-copper reagents in a sequential cross-coupling reaction without external transition metals. The use of propargylic acetates as intermediates allows for the selective synthesis of these valuable products. This method is characterized by easily accessible substrates, mild reaction conditions, a wide scope of applicability, and scalability in practical synthesis.
We report an efficient one-pot, two-step procedure for the modular synthesis of a-difunctionalized alkynes and trisubstituted allenes by sequential cross-coupling of benzal gem-diacetates with organozinc or-copper reagents in the absence of external transition metals. The intermediacy of propargylic acetates enables the divergent and selective synthesis of these valuable products. This method features its readily accessible substrates, relatively mild conditions, wide scope, and scalability in practical synthesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据