期刊
ORGANIC CHEMISTRY FRONTIERS
卷 10, 期 10, 页码 2491-2497出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qo00058c
关键词
-
The selective reductive N-methylation and N,N-dimethylation of primary amines using CO2 is challenging. This study reports a highly selective N,N'-diisopropylcarbodiimide-catalyzed methylation of primary amines using 1 atm CO2 under metal-free conditions. The selectivity of methylation is controlled by the steric effects of amines and boranes.
The selective reductive N-methylation and N,N-dimethylation of primary amines using CO2 are some of the most significant challenges faced by organic chemists. Herein, we report the highly selective N,N '-diisopropylcarbodiimide-catalyzed methylation of primary amines using 1 atm CO2 under metal-free conditions. Borane-piperazine and borane-trimethylamine complexes were used as reducing agents for the N-methylation and N,N-dimethylation of various aromatic primary amines, respectively, in the presence of CO2. Mechanistic studies suggest that the selectivity of methylation is controlled by the steric effects of amines and boranes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据