期刊
RESPIRATORY RESEARCH
卷 24, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12931-023-02413-6
关键词
COVID-19; Idiopathic pulmonary fibrosis; microRNA; Post-COVID-19 lung fibrosis
This study identified overlapping miRNAs in COVID-19 and IPF patients, which are associated with the progression of lung fibrosis. The study also reported elevated levels of pro-fibrotic miRNAs and imbalances in anti-fibrotic miRNAs in COVID-19 patients.
BackgroundPulmonary fibrosis is an emerging complication of SARS-CoV-2 infection. In this study, we speculate that patients with COVID-19 and idiopathic pulmonary fibrosis (IPF) may share aberrant expressed microRNAs (miRNAs) associated to the progression of lung fibrosis.ObjectiveTo identify miRNAs presenting similar alteration in COVID-19 and IPF, and describe their impact on fibrogenesis.MethodsA systematic review of the literature published between 2010 and January 2022 (PROSPERO, CRD42022341016) was conducted using the key words (COVID-19 OR SARS-CoV-2) AND (microRNA OR miRNA) or (idiopathic pulmonary fibrosis OR IPF) AND (microRNA OR miRNA) in Title/Abstract.ResultsOf the 1988 references considered, 70 original articles were appropriate for data extraction: 27 studies focused on miRNAs in COVID-19, and 43 on miRNAs in IPF. 34 miRNAs were overlapping in COVID-19 and IPF, 7 miRNAs presenting an upregulation (miR-19a-3p, miR-200c-3p, miR-21-5p, miR-145-5p, miR-199a-5p, miR-23b and miR-424) and 9 miRNAs a downregulation (miR-17-5p, miR-20a-5p, miR-92a-3p, miR-141-3p, miR-16-5p, miR-142-5p, miR-486-5p, miR-708-3p and miR-150-5p).ConclusionSeveral studies reported elevated levels of profibrotic miRNAs in COVID-19 context. In addition, the balance of antifibrotic miRNAs responsible of the modulation of fibrotic processes is impaired in COVID-19. This evidence suggests that the deregulation of fibrotic-related miRNAs participates in the development of fibrotic lesions in the lung of post-COVID-19 patients.
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