☆ 4.8 Article

Enantio- and diastereodivergent synthesis of fused indolizines enabled by synergistic Cu/Ir catalysis

CHEMICAL SCIENCE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Physical

Asymmetric transformations enabled by synergistic dual transition-metal catalysis

Liang Wei et al.

Summary: Synergistic dual transition-metal catalysis has gained increasing prominence in the enantioselective construction of chemical bonds, showing greater reactivity, selectivity, and efficiency than traditional mono-transition-metal catalysis. This review presents recent examples of asymmetric reactions enabled by synergistic dual metal catalysis, discussing the mechanism, kinetics, and selectivity in detail to showcase the cooperative and independent action of two distinct transition-metal complexes.

CHEM CATALYSIS (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dispersion and Steric Effects on Enantio-/Diastereoselectivities in Synergistic Dual Transition-Metal Catalysis

Bo Li et al.

Summary: Comprehensive computational studies were conducted to investigate the mechanisms of enantioselective Cu/Pd and stereodivergent Cu/Ir dual-catalytic syntheses of alpha,alpha-disubstituted alpha-amino acids (alpha-AAs). The results demonstrate how ligand-encoded chiral information is transferred to the alpha-/beta-sites of the resulting alpha-AAs and how the mode of regio-/stereoselection is altered by differences in transition-metal-stabilized coupling partners.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

添加到收藏夹

Article Chemistry, Organic

Chiral Phosphoric Acid-Catalyzed Asymmetric Arylation of Indolizines: Atroposelective Access to Axially Chiral 3-Arylindolizines

Xiaoxiao Song et al.

Summary: We have developed a highly straightforward strategy for the synthesis of a new axially chiral 3-arylindolizine scaffold using chiral phosphoric acid catalyst. The reaction showed good scalability and yielded a series of axially chiral 3-arylindolizines with excellent enantioselectivity. This approach not only has a broad substrate scope and mild reaction conditions, but also demonstrates the potential utility of the formed axially chiral compounds.

ORGANIC LETTERS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis

Yu-Hua Wen et al.

Summary: The authors have developed a method to construct four stereoisomers of oxindoles with high enantioselectivity and diastereoselectivity using cooperative copper- and organocatalysis. The ability to precisely control the reactive site planar in the region is of great importance in asymmetric stereodivergent catalysis. This method provides a new strategy for the synthesis of chiral functional molecules and has potential applications in alkaloid synthesis.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran-3(2H)-one

Yang Xu et al.

Summary: This article describes a novel stereodivergent allylic alkylation reaction of benzofuran-3(2H)-one using the synergistic catalysis of a chiral N,N'-dioxide-Co(or Ni) complex and a phosphoramidite-Ir catalyst, leading to the synthesis of all four stereoisomers of the targeted molecule rocaglaol. Furthermore, a preliminary study reveals the pronounced influence of stereochemistry variations on the anticancer activity of rocaglaol.

CHEM (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Diastereo- and Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters via Iridium/Europium Bimetallic Catalysis

Wei Wang et al.

Summary: In this study, we report a novel method using a bimetallic catalyst for the asymmetric allylation of challenging trisubstituted allylic esters, achieving the construction of vicinal all-carbon quaternary stereocenters.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent synthesis of enantioenriched azepino[3,4,5-cd]-indoles via cooperative Cu/Ir-catalyzed asymmetric allylic alkylation and intramolecular Friedel-Crafts reaction

Lu Xiao et al.

Summary: This study reports an efficient catalytic asymmetric formal 1,3-dipolar cycloaddition reaction for the construction of azepino[3,4,5-cd]-indoles fused with a challenging seven-membered N-heterocycle. The full stereodivergence of this transformation was established via synergistic catalysis followed by acid-promoted epimerization, which allows predictable access to multiple stereoisomers.

CHEMICAL SCIENCE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synergistic Catalysis with Azomethine Ylides

Liang Wei et al.

Summary: Azomethine ylides are important intermediates for the construction of chiral N-containing compounds. Through synergistic catalysis and azomethine ylide chemistry, novel catalytic systems have been developed to convert readily available azomethine ylides into high-valued molecules. The synergistic catalyst system shows enhanced catalytic efficiency and chiral induction ability compared to traditional mono-catalysis, and can be applied in the synthesis of bioactive compounds and natural products.

CHINESE JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Synthesis of Enantioenriched γ-Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis

Lu Xiao et al.

Summary: Utilizing a new reaction model, gamma-butyrolactones with diverse stereoisomers were prepared stereospecifically through a synergistic Cu/Ir-catalyzed asymmetric cascade reaction, allowing control of vicinal stereocenters. The study of the chiral intermediate shed light on the regio- and stereoselectivity of the initial bond formation process, while control experiments provided insight into catalyst interactions in the dual catalytic system. Enantioenriched products were further converted into structurally complex chiral molecules and organocatalysts, expanding the synthetic accessibility of these compounds.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Diastereodivergent Synthesis of β-Amino Alcohols by Dual-Metal-Catalyzed Coupling of Alkoxyallenes with Aldimine Esters

Minghui Zhu et al.

Summary: The study presents a dual-metal catalyzed diastereodivergent coupling method for the synthesis of beta-amino alcohols with multiple stereoisomers, enabling the concise preparation of natural products such as mycestericins F and G.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Carbon-Carbon Bond Formation between Iminium and Enolate Intermediates by Synergistic Organocatalysis

Byungjun Kim et al.

Summary: A stereodivergent method for the Michael addition of aryl acetic acid esters to alpha,beta-unsaturated aldehydes has been developed using a combination of a chiral pyrrolidine and a chiral Lewis base as catalysts. The reaction allows for the synthesis of products with high enantio- and diastereoselectivity, which can be further transformed into a variety of valuable enantioenriched structures.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Iridium-catalyzed Z-retentive asymmetric allylic substitution reactions

Ru Jiang et al.

Summary: The study introduces iridium-catalyzed asymmetric allylic substitution reactions that can preserve the Z-olefin geometries while establishing adjacent quaternary stereocenters. This method shows promise for the preparation of chiral Z-olefinic compounds.

SCIENCE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges

Imtiaz Khan et al.

Summary: This review summarizes recent developments in synthetic methods for the synthesis of various heterocycles using alkynoates as readily available starting materials under transition-metal catalysis. These methods enable the synthesis of a range of oxygen-, nitrogen-, sulfur-containing heterocycles alongside fused- and spiro-heterocyclic compounds through compact reaction pathways.

TOPICS IN CURRENT CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Organic

Chiral Phosphoric Acid Catalyzed Desymmetrization of Cyclopentendiones via Friedel-Crafts Conjugate Addition of Indolizines

Qijian Ni et al.

Summary: The research has successfully developed an organocatalytic highly diastero- and enantioselective Friedel-Crafts conjugate addition method for adding indolizines to cyclopentenediones to obtain the desired products. The utility of the method was demonstrated through various late-stage functionalizations.

ORGANIC LETTERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis

Shao-Qian Yang et al.

Summary: The protocol describes the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes with a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A wide range of conjugated enynes are coupled with various alpha-fluoroesters in high yields and diastereoselectivity. The novel stereodivergent axial-to-central chirality transfer process enables precise access to the corresponding four stereoisomers of fluorinated hydrofurans.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Physical

Challenges and Opportunities in Multicatalysis

Sebastian Martinez et al.

Summary: Multicatalysis is an emerging field in synthetic chemistry that aims to efficiently convert simple starting materials into complex products, enhancing resource utilization. By utilizing multiple catalysts in single or sequential reactions, multicatalysis enables efficient transformations that reduce time, waste, and cost.

ACS CATALYSIS (2021)

添加到收藏夹

Article Chemistry, Organic

Iridium Catalysed Asymmetric Allylic Substitution Reaction of Indolizine Derivatives

Jiamin Lu et al.

Summary: The highly efficient direct asymmetric allylic substitution (AAS) reaction of indolizine derivatives with allylic alcohols was achieved by combining a chiral iridium complex catalyst with Lewis acid under mild conditions, delivering enantioenriched products in high yields and excellent selectivities. This protocol stands out for its availability of starting materials, mild conditions, broad substrate scope, high yields, excellent selectivity, and easy scalability, providing an efficient approach for the synthesis of chiral indolizines.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Review Chemistry, Organic

Recent Developments in the Cyclization of Alkynes and Nitrogen Compounds for the Synthesis of Indole Derivatives

Jose S. S. Neto et al.

Summary: This review highlights the most useful approaches for synthesizing indole derivatives using transition-metal catalyzed cyclization reactions of alkynes and nitrogen compounds, as well as methodologies carried out under metal-free conditions. The data published in the past decade is predominantly covered in this review.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles

Youbin Peng et al.

Summary: This study presents an enantio- and diastereodivergent synthesis of rigid spirocycles through dual-metal catalysis, offering a promising approach for the development of new N-olefin ligands. Preliminary mechanistic studies were conducted to understand the bimetallic catalysis process.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enantio- and Diastereodivergent Construction of 1,3-Nonadjacent Stereocenters Bearing Axial and Central Chirality through Synergistic Pd/Cu Catalysis

Jiacheng Zhang et al.

Summary: This study presents a method for the construction of 1,3-nonadjacent stereocenters through Pd/Cu-catalyzed asymmetric synthesis, providing highly enantio- and diastereoselective chiral products; The protocol is applicable to a wide range of substrates, including challenging allenylic esters with less sterically bulky substituents; Moreover, various transformations involving axial-to-central chirality transfer were conducted, yielding useful structural motifs containing nonadjacent stereocenters in a diastereodivergent manner.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synergistic Pd/Amine-Catalyzed Stereodivergent Hydroalkylation of 1,3-Dienes with Aldehydes: Reaction Development, Mechanism, and Stereochemical Origins

Hongfa Wang et al.

Summary: A new method for metal-hydride-catalyzed hydroalkylation of 1,3-dienes with aldehydes is described, providing access to chiral molecules with allylic stereocenters. By choosing a combination of chiral palladium and amine catalysts, highly diastereo- and enantioselective access to complementary diastereomers is achieved. The mechanism involves PdH formation and migratory insertion into the alkene, followed by C-C bond formation, with the origin of stereoselectivities investigated through distortion/interaction analysis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C-H Functionalization/Oxa-Michael Addition Cascade

Dong-Xing Zhu et al.

Summary: A one-pot reaction has been developed for the stereodivergent synthesis of diverse 2,3-disubstituted dihydrobenzofurans under mild conditions with high yields and stereoselectivity. By appropriate permutations of two chiral catalysts, a wide range of chiral products can be accessed, demonstrating the ability of two chiral catalysts to independently control two contiguous stereogenic centers.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Catalytic asymmetric Nakamura reaction by gold(I)/chiral N,N'-dioxide-indium(III) or nickel(II) synergistic catalysis

Xinyue Hu et al.

Summary: This study demonstrates the catalytic asymmetric intermolecular addition of 1,3-dicarbonyl compounds to unactivated 1-alkynes through the synergistic activation of chiral N,N'-dioxide-indium(III) or nickel(II) Lewis acid and achiral gold(I) π-acid. A potential catalytic cycle and transition state model were proposed based on experimental investigations.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Physical

Mechanistic Study of Ni and Cu Dual Catalyst for Asymmetric C-C Bond Formation; Asymmetric Coupling of 1,3-Dienes with C-nucleophiles to Construct Vicinal Stereocenters

Jingzhao Xia et al.

Summary: This study presents a comprehensive investigation of the reaction mechanism for a coupling reaction catalyzed by a Ni/Cu cooperative catalyst system, providing direct access to valuable stereocenters with high enantio- and diastereoselectivity. The mechanism of the bimetallic cooperative catalyst system was elucidated through isolation and characterization of key complexes, deuterium labeling experiments, kinetic studies, and density functional theory calculations. The turnover-limiting step involves a proton-transfer step between Ni and Cu complexes to yield the desired products with specific stereochemistry.

ACS CATALYSIS (2021)

添加到收藏夹

Article Chemistry, Physical

Mechanistic Origins of Stereodivergence in Asymmetric Cascade Allylation and Cyclization Reactions Enabled by Synergistic Cu/Ir Catalysis

Hui Xu et al.

Summary: The stereodivergent synthesis of bioactive tetrahydro-gamma-carbolines was achieved through synergistic chiral Cu/Ir catalysis, involving the generation of three stereogenic centers via two consecutive C-C formation procedures. Density functional theory calculations were used to elucidate the mechanism and stereochemistry origins of the catalytic asymmetric cascade allylation and iso-Pictet-Spengler cyclization reaction. The study provides insights into the control of absolute stereoselectivity by two distinct chiral metal catalysts, offering potential for further development of stereodivergent synthesis via cooperative bimetallic catalysis.

ACS CATALYSIS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ir-Catalyzed Enantioselective Friedel-Crafts Type Allylic Substitution of Indolizines

Pusu Yang et al.

Summary: Indolizine is an important N-containing heterocyclic nucleus, and their derivatives exhibit interesting biological activities. However, asymmetric synthesis of indolizine derivatives has been rarely reported.

ACTA CHIMICA SINICA (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Synergistic Pd/Cu Catalysis in Organic Synthesis

Yue Wu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tandem Insertion-[1,3]-Rearrangement: Highly Enantioselective Construction of α-Aminoketones

Yushuang Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Organic

Water-Soluble NIR Absorbing and Emitting Indolizine Cyanine and Indolizine Squaraine Dyes for Biological Imaging

William E. Meador et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Review Chemistry, Organic

Strategic approaches to the synthesis of pyrrolizidine and indolizidine alkaloids

Nina K. Ratmanova et al.

TETRAHEDRON (2020)

添加到收藏夹

Article Chemistry, Physical

Diastereodivergent synthesis of enantioenriched alpha,beta-disubstituted gamma-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis

Santanu Singha et al.

NATURE CATALYSIS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Catalytic Asymmetric Reactions with N-Metallated Azomethine Ylides

Liang Wei et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates

Rui He et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Review Chemistry, Organic

[3+2]-Cycloaddition of Catalytically Generated Pyridinium Ylide: A General Access to Indolizine Derivatives

Shanliang Dong et al.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Diversified Transformations of Tetrahydroindolizines to Construct Chiral 3-Arylindolizines and Dicarbofunctionalized 1,5-Diketones

Dong Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Synergistic Dual Transition Metal Catalysis

U. Bin Kim et al.

CHEMICAL REVIEWS (2020)

添加到收藏夹

Article Chemistry, Organic

Enantioselective Synthesis of 3-Allylindolizines via Sequential Rh-Catalyzed Asymmetric Allylation and Tschitschibabin Reaction

Ke Li et al.

ORGANIC LETTERS (2020)

添加到收藏夹

Article Chemistry, Organic

One-pot chemoselective domino condensation to form a fused pyrrolo-pyrazino-indolizine framework: discovery of novel AIE molecules

Jinbiao Li et al.

ORGANIC CHEMISTRY FRONTIERS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Diversified Cycloisomerization/Diels-Alder Reactions of 1,6-Enynes through Bimetallic Relay Asymmetric Catalysis

Haifeng Zheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bimetallic Catalytic Asymmetric Tandem Reaction of β-Alkynyl Ketones to Synthesize 6,6-Spiroketals

Shulin Ge et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Correction Multidisciplinary Sciences

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity (vol 9, 4406, 2018)

Chia-Yu Chung et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts

Zhi-Tao He et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

Mao-Mao Zhang et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Coupling of 1,3-Dienes with Aldimine Esters Enabled by Synergistic Pd and Cu Catalysis

Qinglong Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Asymmetric Synthesis of Oxa-Bridged Oxazocines through a Catalytic RhII/ZnII Relay [4+3] Cycloaddition Reaction

Chaoran Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Organic

Copper-Catalyzed Asymmetric Propargylation of Indolizines

Lei Yang et al.

ORGANIC LETTERS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

Qiang Cheng et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Review Chemistry, Organic

Recent Advances in Metallated Azomethine Ylides for the Synthesis of Chiral Unnatural α-Amino Acids

Liang Wei et al.

CHINESE JOURNAL OF ORGANIC CHEMISTRY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Stereodivergent Catalysis

Irina P. Beletskaya et al.

CHEMICAL REVIEWS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Theoretical insight into phosphoric acid-catalyzed asymmetric conjugate addition of indolizines to α,β-unsaturated ketones

Haohua Chen et al.

CHINESE CHEMICAL LETTERS (2018)

添加到收藏夹

Article Chemistry, Medicinal

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

Sujin Park et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

Liang Wei et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

Xingyu Jiang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to alpha,alpha-Disubstituted alpha-Amino Acids Bearing Vicinal Stereocenters

Xiaohong Huo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bimetallic Rhodium(II)/Indium(III) Relay Catalysis for Tandem Insertion/Asymmetric Claisen Rearrangement

Yushuang Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Lewis Acid Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic N-Sulfonylaziridines

Pei-Jun Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis

Xingyu Jiang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis

Xiaohong Huo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen's Amine

Faben A. Cruz et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Stereodivergence in Asymmetric Catalysis

Simon Krautwald et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Exploiting non-covalent π interactions for catalyst design

Andrew J. Neel et al.

NATURE (2017)

添加到收藏夹

Article Chemistry, Physical

Accurately extracting the signature of intermolecular interactions present in the NCI plot of the reduced density gradient versus electron density

Corentin Lefebvre et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Asymmetric Cycloaddition and Cyclization Reactions Catalyzed by Chiral N,N′-Dioxide-Metal Complexes

Xiaohua Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Catalytic Asymmetric Conjugate Addition of Indolizines to α,β-Unsaturated Ketones

Jose Tiago Menezes Correia et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Catalytic Strategies for Diastereodivergent Synthesis

Lili Lin et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists

Yu Xue et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones

Xiaohong Huo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor

Eunha Kim et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes

Tobias Sandmeier et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Review Chemistry, Organic

Enantioselective cooperative catalysis

Suleman M. Inamdar et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

添加到收藏夹

Review Chemistry, Multidisciplinary

Asymmetric Organocatalysis Combined with Metal Catalysis: Concept, Proof of Concept, and Beyond

Dian-Feng Chen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis

Simon Krautwald et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

添加到收藏夹

Review Chemistry, Medicinal

Indolizine: a biologically active moiety

Vikas Sharma et al.

MEDICINAL CHEMISTRY RESEARCH (2014)

添加到收藏夹

Review Chemistry, Multidisciplinary

Combining transition metal catalysis and organocatalysis - an update

Zhenting Du et al.

CHEMICAL SOCIETY REVIEWS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Enantio- and Di Aereodivergent Dual Catalysis: α-Allylation of Branched Aldehydes

Simon Krautwald et al.

SCIENCE (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Iridium-Catalyzed Allylic Alkylation Reaction with N-Aryl Phosphoramidite Ligands: Scope and Mechanistic Studies

Wen-Bo Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synergistic catalysis: A powerful synthetic strategy for new reaction development

Anna E. Allen et al.

CHEMICAL SCIENCE (2012)

添加到收藏夹

Review Chemistry, Medicinal

Recent progress in synthesis and bioactivity studies of indolizines

Girija S. Singh et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Facile Cu(I)/TF-BiphamPhos-Catalyzed Asymmetric Approach to Unnatural α-Amino Acid Derivatives Containing gem-Bisphosphonates

Zhi-Yong Xue et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

添加到收藏夹

Article Chemistry, Organic

A Facile Cu(I)/BINAP-Catalyzed Asymmetric Approach to Functionalized Pyroglutamate Derivatives Bearing a Unique Quaternary Stereogenic Center

Huai-Long Teng et al.

ORGANIC LETTERS (2011)

添加到收藏夹

Review Chemistry, Multidisciplinary

Mechanistically Driven Development of Iridium Catalysts for Asymmetric Allylic Substitution

John F. Hartwig et al.

ACCOUNTS OF CHEMICAL RESEARCH (2010)

添加到收藏夹

Review Chemistry, Multidisciplinary

Phosphoramidites: Privileged Ligands in Asymmetric Catalysis

Johannes F. Teichert et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

添加到收藏夹

Article Chemistry, Medicinal

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Do special noncovalent pi-pi stacking interactions really exist?

Stefan Grimme

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

Combinatorial discovery of full-color-tunable emissive fluorescent probes using a single core skeleton, 1,2-dihydropyrrolo[3,4-β]indolizin-3-one

Eunha Kim et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

添加到收藏夹

Article Chemistry, Medicinal

Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines

David A. James et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of protein-protein binding disruptors using multi-component condensations small molecules

Karim Bedjeguelal et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

添加到收藏夹

Article Chemistry, Multidisciplinary

A highly enantio- and diastereoselective Cu-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with nitroalkenes

XX Yan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

添加到收藏夹

Article Chemistry, Medicinal

Antimycobacterial activity of 1-substituted indolizines

LL Gundersen et al.

ARCHIV DER PHARMAZIE (2003)

添加到收藏夹

Review Biochemical Research Methods

The importance of stereoselective determination of drugs in the clinical laboratory

KM Rentsch

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.