4.7 Article

Amelioration of walnut-derived novel peptides against d-galactose-induced cognitive impairment by modulating the gut microbiota composition

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Food Science & Technology

Production, bioactivities and bioavailability of bioactive peptides derived from walnut origin by-products: a review

Dandan Liu et al.

Summary: This review provides an overview of the current research status of bioactive peptides derived from walnut by-products. The review covers the preparation, separation, purification, identification, bioactivities, and bioavailability of these peptides. It highlights the various biological activities exhibited by walnut peptides, including antioxidative, antihypertensive, neuroprotective, antidiabetic, anticancer, and antihyperuricemia activities. The review also emphasizes the need for further research in improving the bioavailability of walnut peptides and exploring their molecular mechanisms. Digestion, absorption, and metabolism processes of walnut peptides are also identified as important areas for future research.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Article Agriculture, Multidisciplinary

PAYCS Alleviates Scopolamine-Induced Memory Deficits in Mice by Reducing Oxidative and Inflammatory Stress and Modulation of Gut Microbiota-Fecal Metabolites-Brain Neurotransmitter Axis

Tiantian Zhao et al.

Summary: PAYCS has positive effects on memory improvement and alleviation of oxidative and inflammatory stress through the modulation of gut microbiota and metabolites.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Agriculture, Multidisciplinary

Sea Cucumber-Derived Peptide Attenuates Scopolamine-Induced Cognitive Impairment by Preventing Hippocampal Cholinergic Dysfunction and Neuronal Cell Death

Yue Zhao et al.

Summary: In this study, the effect of the sea cucumber-derived peptide FYDWPK on scopolamine-induced neurotoxicity was evaluated in an animal model. The results showed that FYDWPK effectively alleviated learning and memory impairment and cholinergic dysfunction in mice with dementia. Furthermore, FYDWPK improved oxidative imbalance and relieved pathological alterations, leading to the alleviation of cognitive and memory impairments.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Kangliang Sheng et al.

Summary: This study evaluated the effect of grape seed proanthocyanidin extract (GSPE) on aging and found that GSPE can improve antioxidant capacity and reduce inflammation levels. The study also discovered that GSPE administration can affect the gut microbiota composition and inhibit the NLRP3 inflammasome signaling pathway, providing a novel strategy for alleviating aging-induced alterations.

FOOD & FUNCTION (2022)

Review Nutrition & Dietetics

Bioactivities, Applications, Safety, and Health Benefits of Bioactive Peptides From Food and By-Products: A Review

Ahmed A. Zaky et al.

Summary: Bioactive peptides derived from food proteins have various significant functions and show potential as functional foods and nutraceuticals. They have been found in a wide range of food sources and have been studied extensively for their health benefits, bioactivities, and applications in different industries.

FRONTIERS IN NUTRITION (2022)

Article Agriculture, Multidisciplinary

Arginine-Containing Peptides Derived from Walnut Protein Against Cognitive and Memory Impairment in Scopolamine-Induced Zebrafish: Design, Release, and Neuroprotection

Shuguang Wang et al.

Summary: The neuroprotective effect of Arg-containing peptides from walnut storage protein sequences in scopolamine-induced zebrafish was investigated in this study. The results showed that these peptides displayed potent neuroprotection through regulation of neurotransmitter levels and antioxidant enzyme activity. Furthermore, Arg-containing peptides released efficiently from walnut protein following hydrolysis and their neuroprotective capacity was confirmed. The combination of in silico hydrolysis and controlled enzymatic release was suggested as an effective approach to obtain these neuroprotective peptides.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Pharmacology & Pharmacy

Active Peptide AR-9 From Eupolyphaga sinensis Reduces Blood Lipid and Hepatic Lipid Accumulation by Restoring Gut Flora and Its Metabolites in a High Fat Diet-Induced Hyperlipidemia Rat

Hong Wang et al.

Summary: This study isolated an active peptide AR-9 from E. sinensis and found that AR-9 could improve symptoms of hyperlipidemia in rats induced by a high-fat diet by modulating gut flora and its metabolites. The results showed that AR-9 decreased lipid factors in plasma, reduced liver damage, and changed the gut microbiota composition. The pathway regulated by AR-9 was involved in arginine biosynthesis. Overall, AR-9 has potential anti-hyperlipidemia effects through interactions between gut microbial shifts and fecal amino acid/lipid metabolism.

FRONTIERS IN PHARMACOLOGY (2022)

Article Food Science & Technology

Antarctic krill peptides improve scopolamine-induced memory impairment in mice

Jingru Zheng et al.

Summary: The study shows that Antarctic krill peptides can repair scopolamine-induced memory impairment by enhancing SOD activity and ACh level while reducing AChE and MDA levels in hippocampal neurons.

FOOD BIOSCIENCE (2022)

Article Biochemistry & Molecular Biology

Polysaccharides from soybean residue fermented by Neurospora crassa alleviate DSS-induced gut barrier damage and microbiota disturbance in mice

Wenli Huang et al.

Summary: Soluble polysaccharides (FSRP) derived from Neurospora crassa-fermented soybean residue can alleviate colitis in mice by reducing inflammation, enhancing gut barrier function, and modulating gut microbiota homeostasis.

FOOD & FUNCTION (2022)

Article Geriatrics & Gerontology

Tea polyphenols ameliorates memory decline in aging model rats by inhibiting brain TLR4/NF-κB inflammatory signaling pathway caused by intestinal flora dysbiosis

Chenmeng Song et al.

Summary: Tea polyphenols were found to improve memory decline in aging model rats by regulating intestinal flora to alleviate brain inflammation. High dose of TP (300 mg/kg) had a more significant improvement on rat behavior, intestinal flora composition, intestinal epithelium morphology and function.

EXPERIMENTAL GERONTOLOGY (2021)

Article Chemistry, Medicinal

Evaluation of the effect of thymoquinone in d-galactose-induced memory impairments in rats: Role of MAPK, oxidative stress, and neuroinflammation pathways and telomere length

Zahra Oskouei et al.

Summary: D-galactose induces aging and memory impairment, while thymoquinone shows neuroprotective effects in rats. Thymoquinone improves memory and learning deficits caused by D-galactose, reduces oxidative stress and neuroinflammation, and enhances memory and learning abilities.

PHYTOTHERAPY RESEARCH (2021)

Article Agriculture, Multidisciplinary

Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota

Jiaming Liu et al.

Summary: The study revealed that Ginkgolide B (GB) significantly improved cognitive function, neurodegeneration, and neuropathological changes in AD model mice. Treatment with GB reduced levels of RAGE and Bax while increasing Bcl-2 levels in AD model mice. Additionally, GB treatment reversed dysbiosis in gut microbiota by restoring the abundance of certain bacterial species.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Agriculture, Multidisciplinary

Characterization and Exploration of Potential Neuroprotective Peptides in Walnut (Juglans regia) Protein Hydrolysate against Cholinergic System Damage and Oxidative Stress in Scopolamine-Induced Cognitive and Memory Impairment Mice and Zebrafish

Shuguang Wang et al.

Summary: The study found that walnut protein hydrolysates (WPH) could improve memory deficits in mice by regulating the cholinergic system and oxidative stress, without obvious anti-inflammatory effects. By using peptidomics and in silico docking prediction, potential neuroprotective peptides were identified, such as FY and SGFDAE, which showed promising AchE and Keap1 inhibitory effects and neuroprotective capacity in scopolamine-induced zebrafish models.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Review Pharmacology & Pharmacy

The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology

Tejaswini Doifode et al.

Summary: Recent studies have shown the impact of the gut microbiota on various neurodegenerative diseases, including Alzheimer's disease. Understanding the role of the microbiota may offer new targets for treatment to delay, progress, or reverse AD, as well as potentially reducing the prevalence of the disease.

PHARMACOLOGICAL RESEARCH (2021)

Article Food Science & Technology

Bioactive peptides and gut microbiota: Candidates for a novel strategy for reduction and control of neurodegenerative diseases

Shujian Wu et al.

Summary: Neurodegenerative diseases are debilitating conditions that can be alleviated by strategies targeting gut microbiota. Bioactive peptides derived from food sources can modulate gut microbiota and serve as novel molecules to control and reduce neurodegenerative diseases. The bioactivity of peptides can be significantly influenced by different production and modification strategies.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

Review Immunology

Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori

Nina Gorle et al.

Summary: Trillions of symbiotic microbial cells colonize our body, with a larger portion residing in the human gut. Changes in gut microbiota have been linked to various diseases, including neurological disorders. Helicobacter species, particularly H. suis, may play a role in neurological disorders via the microbiome-gut-brain axis, but further research is needed to understand their impact on the brain.

FRONTIERS IN IMMUNOLOGY (2021)

Article Food Science & Technology

Tilapia Head Protein Hydrolysate Attenuates Scopolamine-Induced Cognitive Impairment through the Gut-Brain Axis in Mice

Jun Ji et al.

Summary: The study demonstrates that bioactive peptides from aquatic products can prevent cognitive impairment by improving cognitive behavior, normalizing the cholinergic system and oxidative stress system in the brain, and reshaping the gut microbiota structure to alleviate cognitive deficits.
Article Neurosciences

Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation

Jianan Qian et al.

Summary: The study showed that dihydromyricetin (DMY) exhibited strong neuroprotective effects against D-galactose (D-Gal)-triggered brain aging in mice, improving spatial cognition and alleviating damage to hippocampal neurons. DMY also suppressed D-Gal-induced senescence of hippocampal neurons, restored catalase activity, and showed potent inhibitory effects on oxidative stress and inflammation-related factors.

NEUROSCIENCE LETTERS (2021)

Article Chemistry, Applied

Separation, identification and molecular binding mechanism of dipeptidyl peptidase IV inhibitory peptides derived from walnut (Juglans regia L.) protein

Xiangzhen Kong et al.

Summary: Walnut protein hydrolysates demonstrated DPP-IV inhibitory activity, with fractions containing lower molecular weight and higher basic amino acid residues showing stronger inhibitory effects. Nine novel DPP-IV inhibitory peptides were identified, which interacted with DPP-IV through multiple binding modes.

FOOD CHEMISTRY (2021)

Article Nutrition & Dietetics

The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models

Xiao-Chen Yu et al.

Summary: This study found that whey protein peptide has antioxidant effects on learning and memory in aging mice, improving oxidative stress, reducing degeneration of nerve cells, and enhancing endogenous antioxidant defense mechanisms.

NUTRIENTS (2021)

Article Microbiology

Effects of Dietary Ferulic Acid on the Intestinal Microbiota and the Associated Changes on the Growth Performance, Serum Cytokine Profile, and Intestinal Morphology in Ducks

Yang Liu et al.

Summary: The study explored the effects of ferulic acid (FA) on ducks' growth performance, serum cytokine profile, intestinal morphology, and intestinal microbiota. Results showed that 400 mg/kg of FA can enhance growth performance, antioxidative and immunological capabilities in ducks, while also improving intestinal morphology.

FRONTIERS IN MICROBIOLOGY (2021)

Article Food Science & Technology

Walnut-Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice

Min Wang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

Article Biochemistry & Molecular Biology

Protective roles of Amanita caesarea polysaccharides against Alzheimer's disease via Nrf2 pathway

Zhiping Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Review Biochemistry & Molecular Biology

Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation

Janos Paloczi et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Medicine, Research & Experimental

Onjisaponin B prevents cognitive impairment in a rat model of D-galactose-induced aging

Gaowen Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Biochemistry & Molecular Biology

Immunomodulation by food: impact on gut immunity and immune cell function

Satoshi Hachimura et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2018)

Article Biochemical Research Methods

Metabolic Fate of C-13-Labeled Polydextrose and Impact on the Gut Microbiome: A Triple-Phase Study in a Colon Simulator

Santosh Lamichhane et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Article Multidisciplinary Sciences

Microbiome-metabolome signatures in mice genetically prone to develop dementia, fed a normal or fatty diet

Elena Sanguinetti et al.

SCIENTIFIC REPORTS (2018)

Article Agriculture, Multidisciplinary

Walnut (Juglans regia) Peptides Reverse Sleep Deprivation-Induced Memory Impairment in Rat via Alleviating Oxidative Stress

Shuguang Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Multidisciplinary Sciences

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

T. Harach et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Our Gut Microbiome: The Evolving Inner Self

Parag Kundu et al.

Review Clinical Neurology

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Eamonn M. M. Quigley

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2017)

Review Medicine, Research & Experimental

Microbiota and Aging. A Review and Commentary

Carmen Garcia-Pena et al.

ARCHIVES OF MEDICAL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

Article Biochemistry & Molecular Biology

Composition, Structure and Functional Properties of Protein Concentrates and Isolates Produced from Walnut (Juglans regia L.)

Xiaoying Mao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Review Cell Biology

Mechanism of Oxidative Stress in Neurodegeneration

Sonia Gandhi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)

Review Neurosciences

The role of acetylcholine in learning and memory

Michael E. Hasselmo

CURRENT OPINION IN NEUROBIOLOGY (2006)

Article Geriatrics & Gerontology

The neurobiology of memory changes in normal aging

CA Erickson et al.

EXPERIMENTAL GERONTOLOGY (2003)