This study presents a visible-light-driven and photocatalyst-free coupling reaction between alkenylboronic acids/esters and α-bromodifluoroacylarenes, offering a streamlined access to Suzuki coupling products. The reactions proceed under metal-free conditions with a wide substrate scope. Mechanistic experiments and DFT calculation studies reveal that halogen bonding interactions between a-bromodifluoroacylarenes and tertiary amines promote the C-sp3-Br bond homolytic cleavage from difluorobromoaryl ketones.
The Suzuki-Miyaura reaction has greatly facilitated the construction of C-C bonds and is well appreciated in medicinal chemistry, yet transition metal residues in this process are an unavoidable challenge. Herein, we report the first visible-light-driven photocatalyst-free coupling reaction of alkenylboronic acids/esters with a-bromodifluoroacylarenes, providing streamlining access to a series of Suzuki coupling products. The reactions proceed under metal-free conditions with a wide substrate scope. Mechanistic experiments and DFT calculation studies revealed that halogen bonding interactions, mainly generated in situ between a-bromodifluoroacylarenes and tertiary amines, could promote the C-sp3-Br bond homolytic cleavage from difluorobromoaryl ketones.
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