Formal synthesis of cyclotheonellazole A

A convergent procedure for the formal synthesis of cyclotheonellazole A in high yields and excellent stereoselectivity has been developed. This synthesis features an efficient preparation of O-pivaloyl-protected alpha-hydroxy-beta-amino amides and a one-pot process to introduce the challenging thiazole moiety. The overall synthesis is very efficient and paves the way for the preparation of analogues for drug development.

Automated summary

A convergent procedure has been developed for the formal synthesis of cyclotheonellazole A, achieving high yields and excellent stereoselectivity. Notably, the synthesis involves efficient preparation of O-pivaloyl-protected alpha-hydroxy-beta-amino amides and a one-pot process for introducing the challenging thiazole moiety. The overall synthetic approach is highly efficient and holds promise for the generation of analogues in drug development.