期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 10, 期 12, 页码 1397-1408出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17474124.2016.1251309
关键词
Hepatic stellate cell; fibrosis; ncRNA; DNA methylation; histone modification; liver disease
资金
- Interuniversity Attraction Poles (Federal Science Policy) [BELSPO P7/47]
- Research Foundation-Flanders (FWO) [SBO 140045, G030616N]
Introduction: Chronic liver injury to hepatocytes or cholangiocytes, when left unmanaged, leads to the development of liver fibrosis, a condition characterized by the excessive intrahepatic deposition of extracellular matrix proteins. Activated hepatic stellate cells constitute the predominant source of extracellular matrix in fibrotic livers and their transition from a quiescent state during fibrogenesis is associated with important alterations in their transcriptional and epigenetic landscape.Areas covered: We briefly describe the processes involved in hepatic stellate cell activation and discuss our current understanding of alterations in the epigenetic landscape, i.e DNA methylation, histone modifications and the functional role of non-coding RNAs that accompany this key event in the development of chronic liver disease.Expert commentary: Although great progress has been made, our understanding of the epigenetic regulation of hepatic stellate cell activation is limited and, thus far, insufficient to allow the development of epigenetic drugs that can selectively interrupt liver fibrosis.
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