☆ 4.5 Review

Recent advances in Prussian blue-based photothermal therapy in cancer treatment

BIOMATERIALS SCIENCE (2023)

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Article Biochemistry & Molecular Biology

Copper-rich multifunctional Prussian blue nanozymes for infected wound healing

Ping Xu et al.

Summary: In this study, a copper-rich multifunctional ultra-small Prussian blue nanozymes (HPP@Cu NZs) was developed for synergistic treatment of infected wounds. The nanozymes exhibited uniform ultra-small size, excellent photothermal response, enzymatic activity, and anti-inflammatory properties. In vitro and in vivo experiments showed that it effectively inhibited and killed bacteria, removed excessive ROS, regulated oxygen levels, and promoted the healing of infected wounds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Materials Science, Biomaterials

Manganese Prussian blue nanozymes with antioxidant capacity prevent acetaminophen-induced acute liver injury

Chongqing Chen et al.

Summary: As one of the leading cases of acute liver failure triggered by excessive Acetaminophen (APAP), the mechanisms of APAP-induced liver injury (AILI) involve breakdown of the antioxidant system, inflammatory response, and apoptosis due to the overaccumulation of reactive oxygen species (ROS). To prevent the overproduction of ROS, manganese Prussian blue nanozymes (MPBZs) with superior antioxidant enzyme-like activity are used for hepatocyte protection. These MPBZs accumulate in the liver and scavenge excess ROS, thus alleviating oxidative stress and mediating various biological signaling pathways for enhanced tolerance against AILI.

BIOMATERIALS SCIENCE (2023)

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Article Chemistry, Physical

Gadolinium-hybridized mesoporous organosilica nanoparticles with high magnetic resonance imaging performance for targeted drug delivery

Junjie Zhang et al.

Summary: In this study, a new type of nano material was successfully prepared for targeted magnetic resonance imaging and chemotherapy of tumors. This nano material showed excellent biocompatibility and high efficiency in killing tumors, and it has potential applications in the field of tumor diagnosis and treatment.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

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Review Pharmacology & Pharmacy

Advances in Single-component inorganic nanostructures for photoacoustic imaging guided photothermal therapy

Houjuan Zhu et al.

Summary: Phototheranostic based on photothermal therapy (PTT) and photoacoustic imaging (PAI) is gaining attention due to its noninvasive, deeply penetrative, and highly selective and effective therapy. Single-component inorganic nanostructures are novel and attractive PAI and PTT combined nanotheranostic agents. They have controllable structure, tunable physiochemical properties, size-dependent optical properties, simple composition, and easy synthesis process. They also have multiple therapeutic and imaging functions, reducing systemic side effects and improving the bioavailability.

ADVANCED DRUG DELIVERY REVIEWS (2023)

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Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

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Article Engineering, Environmental

Glucose-responsive mesoporous prussian blue nanoprobes coated with ultrasmall gold and manganese dioxide for magnetic resonance imaging and enhanced antitumor therapy

Yuehua Shi et al.

Summary: In this study, an intelligent tumor microenvironment-responsive nanoprobe was successfully constructed for tumor therapy. The nanoprobe exhibited good biocompatibility and could be used for magnetic resonance imaging, photothermal therapy, and enhanced chemodynamic therapy. The results showed improved generation efficiency of hydroxyl free radicals and enhanced magnetic resonance relaxation. The nanoprobe also demonstrated excellent photothermal performance, leading to enhanced antitumor efficacy.

CHEMICAL ENGINEERING JOURNAL (2023)

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Review Chemistry, Multidisciplinary

Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy

Kuikun Yang et al.

Summary: Nanomedicines, particularly polyprodrug nanomedicines, show promise in cancer therapies due to well-controlled composition and drug loading, presenting significant potential for combating tumors.

ADVANCED MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Toxicity of metal-organic framework nanoparticles: from essential analyses to potential applications

Romy Ettlinger et al.

Summary: The field of metal-organic frameworks (MOFs), particularly MOF nanoparticles, has seen significant growth in the last two decades. This tutorial review emphasizes the importance of systematic toxicity assessment and discusses the current state of in vitro and in vivo toxicity studies of MOF nanoparticles, as well as the key factors affecting their toxicity.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Chemistry, Physical

A biodegradable Nano-donut for magnetic resonance imaging and enhanced chemo/photothermal/chemodynamic therapy through responsive catalysis in tumor microenvironment

Shaoqi Guan et al.

Summary: The biodegradable Nanodonut (CMPB-MoS2-PEG) with dual therapeutic functions enhances photothermal therapy and chemotherapy through responsive catalysis in the tumor microenvironment. The Nanodonut shows improved photothermal conversion efficiency and excellent biological safety in tumor treatment.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Targeting bone microenvironments for treatment and early detection of cancer bone metastatic niches

Hongbin Yang et al.

Summary: The article discusses the harmful effects of bone metastasis on many cancers and the impact of dynamic interactions between tumor cells and bone tissues on tumor growth and progression. It proposes clinical benefits of targeting bone microenvironments to improve cure rates and reduce related diseases. It also examines research on using nano drugs and probes to inhibit tumor migration and detect early bone metastasis.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Physical

CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma

Preethi Bala Balakrishnan et al.

Summary: This study introduces a novel nanoimmunotherapy combining PBNP-PTT with aCD137 mAb therapy for melanoma, showing promising effects on tumor rejection through activated dendritic cells and tumor-infiltrating CD8(+) T cells, generating CD4(+) and CD8(+) T cell memory for tumor rechallenge rejection without long-term toxicity.

NANO RESEARCH (2022)

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Article Materials Science, Biomaterials

Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages

Ansuja Pulickal Mathew et al.

Summary: Excessive inflammatory response during sepsis can cause irreversible damage to healthy tissues. This study presents the use of hyaluronic acid-stabilized Prussian blue nanoparticles to reduce inflammation and inhibit leukocyte infiltration in an LPS-induced endotoxemia model. The nanoparticles can scavenge intracellular peroxide and prevent the activation of tissue-resident macrophages.

BIOMATERIALS SCIENCE (2022)

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Article Engineering, Biomedical

Multifunctional microcapsules: A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy

Hufei Wang et al.

Summary: This study successfully prepared a versatile microcapsule with the ability of multi-modality imaging and synergistic therapy. These microcapsules can enhance the contrast of ultrasound, magnetic resonance, and photoacoustic imaging simultaneously, and embed drugs and nanoparticles inside for targeted therapy. In vitro and in vivo experiments showed that these microcapsules have excellent targeting capability and therapeutic effect, making them a promising smart platform.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

An injectable and biodegradable hydrogel incorporated with photoregulated NO generators to heal MRSA-infected wounds

Xinyi Lv et al.

Summary: An injectable, degradable, and photoactivated antibacterial hydrogel (MPDA-BNN6@Gel) was developed for the treatment of infected wounds. The hydrogel could generate local hyperthermia and release large quantities of NO gas to treat the infection under laser irradiation. It was found that the hydrogel eradicated bacteria by damaging the cell membrane, genetic metabolism, and material energy. Additionally, the hydrogel promoted wound healing in vivo in the absence of laser irradiation.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy

Yongming Zhang et al.

Summary: This study presents a DNA-assembled nanomaterial that achieves uniform distribution of photothermal agents in tumor tissues, enhancing photothermal therapy efficiency. By utilizing the explosive dissociation of hydrogen bonds, the large-sized nanomaterial is broken down into smaller photothermal agents, promoting their diffusion and improving their anti-tumor effects.

BIOMATERIALS (2022)

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Article Engineering, Environmental

Zinc-enriched nanosystem for dual glycolysis regulation and photothermal therapy to synergistically inhibit primary melanoma and lung metastasis

Zhaoxu Meng et al.

Summary: In this study, a zinc-enriched nanosystem was developed for the treatment of melanoma. The nanosystem demonstrated high photothermal conversion efficacy and was able to regulate glycolysis and provide photothermal therapy. Upon laser irradiation, the nanosystem generated heat energy and released glycolysis regulators, resulting in the inhibition of lactate dehydrogenase and hexokinase II and down-regulation of glycolysis. Additionally, the nanosystem showed potent antitumor efficacy by down-regulating the expression of Akt, p-Akt, HIF-1 alpha, inducing cell cycle arrest, and inhibiting distant metastasis. Overall, this study provides a novel perspective for tumor metabolism and phototherapy to achieve complete tumor regression.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Multidisciplinary

Supramolecular hydrogel-loaded Prussian blue nanoparticles with photothermal and ROS scavenging ability for tumor postoperative treatments

Zongrui Tong et al.

Summary: This study developed a multifunctional hydrogel that can effectively prevent tumor recurrence and accelerate wound healing, suitable for tumor postoperative treatments. Through combinational chemotherapy/photothermal therapy, cancer cells were eliminated and tumor recurrence was prevented. The hydrogel was proven to accelerate tissue regeneration and eliminate in vivo reactive oxygen species.

COMPOSITES PART B-ENGINEERING (2022)

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Review Chemistry, Inorganic & Nuclear

Low temperature photothermal therapy: Advances and perspectives

Ke Yang et al.

Summary: Photothermal therapy (PTT) is attracting increasing attention due to its high selectivity, non-invasiveness, negligible drug resistance, oxygen independence, and minimal side effects. However, there are still challenges in its clinical application, such as effectively eliminating tumors without damaging surrounding normal tissues, and overcoming cell tolerance to heat.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Chemistry, Physical

Designed formation of Prussian Blue/CuS Janus nanostructure with enhanced NIR-I and NIR-II dual window response for tumor thermotherapy

Dan Li et al.

Summary: This study develops novel PB@PAA/CuS Janus nanoparticles with enhanced photothermal conversion efficiency, demonstrating enhanced absorption capabilities and deep tissue penetration in the NIR-I and NIR-II dual windows.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Physical

A step-by-step multiple stimuli-responsive metal-phenolic network prodrug nanoparticles for chemotherapy

Xiaoqing Yi et al.

Summary: This study developed a metal phenolic network-based drug delivery system with excellent stability and satisfactory drug loading capacity, which effectively inhibited the growth of tumors.

NANO RESEARCH (2022)

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Article Materials Science, Multidisciplinary

Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy

Xin-Yu Qu et al.

Summary: The development of pH-sensitive NIR dye BTN with robust photothermal conversion efficiency and lysosome-targeting capability, fabricated as NPs with amphiphilic polymers, demonstrates outstanding imaging-guided photothermal therapy for tumor ablation in tumor-bearing nude mice.

RARE METALS (2022)

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Article Chemistry, Multidisciplinary

Antithrombotic Therapy by Regulating the ROS-Mediated Thrombosis Microenvironment and Specific Nonpharmaceutical Thrombolysis Using Prussian Blue Nanodroplets

Wenli Zhang et al.

Summary: This study presents a nanodroplet system based on Prussian blue, which achieves drug-free thrombolysis through the combination of photothermal therapy and optical droplet vaporization. Prussian blue also regulates the vascular microenvironment and reduces inflammation. The study demonstrates the potential of optical droplet vaporization in thrombus therapy and elucidates the mechanism of photothermal therapy thrombolysis.

SMALL (2022)

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Article Multidisciplinary Sciences

Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

Xin Li et al.

Summary: The study demonstrates that co-delivery of indocyanine green and calcipotriol using tumor cell-derived microparticles can enhance the efficacy of photothermal therapy by remodeling the tumor extracellular matrix and improving anti-tumor immune responses.

NATURE COMMUNICATIONS (2022)

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Article Pharmacology & Pharmacy

Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

Yun Yang et al.

Summary: A multifunctional nanoparticle system has been developed to deliver chemotherapy drugs synchronously to breast cancer tumor sites, showing promising synergistic effects.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Chemistry, Multidisciplinary

Proton-Driven Transformable 1O2-Nanotrap for Dark and Hypoxia Tolerant Photodynamic Therapy

Dapeng Chen et al.

Summary: In this study, a proton-driven transformable O-1(2)-nanotrap was developed to overcome tumor hypoxia and endosomal entrapment, leading to sustained antitumor performance.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

Near-infrared light triggered multi-hit therapeutic nanosystem for tumor specific photothermal effect amplified signal pathway regulation and ferroptosis

He Lian et al.

Summary: This study proposes a multi-hit therapeutic nanosystem for tumor treatment using a biodegradable hollow mesoporous Prussian blue (HMPB) nanosystem. The nanosystem encapsulates the heat shock protein 90 (HSP90) inhibitor 17-dimethylamino-ethylamino-17-demethoxydeldanamycin (17-DMAG) and includes thermotropic phase transition material star-PEG-PCL (sPP) and hyaluronic acid (HA) for enhanced tumor cell endocytosis. The nanosystem utilizes photothermal-conversion effect, phase transition, and drug release to inhibit HSP90 activity, block multiple signaling pathways, and induce ferroptosis in tumor cells, leading to potent antitumor effects in vitro and in vivo.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Photothermal therapy with regulated Nrf2/NF-κB signaling pathway for treating bacteria-induced periodontitis

Yujuan Tian et al.

Summary: In this study, a versatile metal-organic framework (MOF)-based nanoplatform (MPB-BA) was prepared using mesoporous Prussian blue (MPB) nanoparticles to load the immunomodulatory drug BA for the treatment of periodontitis. The results showed that MPB-BA exerted antioxidant and anti-inflammatory effects by scavenging intracellular ROS and switching macrophages phenotype. Moreover, MPB-BA exhibited efficient photothermal antibacterial activity under near-infrared (NIR) light irradiation. In vivo experiments confirmed the superior therapeutic effects of MPB-BA compared to minocycline hydrochloride.

BIOACTIVE MATERIALS (2022)

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Article Materials Science, Multidisciplinary

Hybrid membrane-camouflaged hollow prussian blue nanoparticles for shikonin loading and combined chemo/photothermal therapy of metastatic TNBC

Jiahao Liang et al.

Summary: This study developed a biomimetic SHK-loading nano-system for the treatment of TNBC. The nano-system demonstrated prolonged circulation time and higher targeting, leading to significant inhibition of TNBC growth and metastasis.

MATERIALS TODAY ADVANCES (2022)

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Article Multidisciplinary Sciences

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

Qiqun Zeng et al.

SCIENCE (2022)

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Article Chemistry, Multidisciplinary

An Endogenous H2S-Activated Nanoplatform for Triple Synergistic Therapy of Colorectal Cancer

Jufeng Chen et al.

Summary: A novel nanomedicine targeting overproduced hydrogen sulfide for precise colorectal cancer therapy has been developed, showing high efficacy in both in vitro and in vivo studies. The nanomedicine utilizes a triple synergistic therapy approach, inducing cell death through chemodynamic therapy and autophagy activation.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Near Infrared-Triggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief

Boshi Tian et al.

Summary: This study presents a NIR-triggered theranostic nanoplatform for enhanced cancer therapy, combining mild photothermal therapy and improved Fenton nanocatalytic therapy against hypoxic tumors. The nanoplatform can induce tumor cell apoptosis, inhibit the production of HSP90, relieve tumor hypoxia, and promote the generation of highly toxic ·OH. It also enables dual-modal imaging for precise diagnosis.

SMALL (2022)

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Article Chemistry, Multidisciplinary

Elastic Nanovaccine Enhances Dendritic Cell-Mediated Tumor Immunotherapy

Qiang Li et al.

Summary: The elasticity-dependent effect of the nanovaccine on dendritic cell-mediated immune responses is studied. The prepared soft mesoporous organosilica-based nanovaccine (SMONV) shows enhanced internalization by dendritic cells and induces effective antigen delivery, leading to immune response activation. Moreover, SMONV also enhances lymphatic drainage of antigens, stimulating robust humoral and cellular immunity.

SMALL (2022)

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Review Pharmacology & Pharmacy

The sound of drug delivery: Optoacoustic imaging in pharmacology

Nian Liu et al.

Summary: Optoacoustic imaging is a unique technique that provides high-resolution images of optical contrast for visualizing biological function in vivo. By detecting ultrasound waves generated through the conversion of light absorption to ultrasound, this method offers a range of applications in various biological and clinical fields.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Engineering, Environmental

Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy

Tongyao Wang et al.

Summary: This study developed a novel nanoreactor that utilizes glucose oxidation to generate highly active radicals for starvation therapy and chemodynamic therapy. It also incorporates photothermal enhancement and release of copper ions for enhanced angiogenesis, thereby combating persistent inflammation and bacterial infection during wound healing.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Inorganic & Nuclear

Bioactive material-based nanozymes with multifunctional attributes for biomedicine: Expanding antioxidant therapeutics for neuroprotection, cancer, and anti-inflammatory pathologies

Diana O. Lopez-Cantu et al.

Summary: Due to the limitations of natural enzymes, nanomaterials-based artificial enzymes, known as nanozymes, have emerged as promising therapeutic targets for oxidative stress-related diseases. This review presents a biochemical rationale for antioxidant nanozymes and discusses recent advances in their development as therapeutic agents. The review focuses on the mimicry of three representative natural enzymes, as well as the properties and applications of metal-based nanozymes in biomedicine, including neuroprotection, cancer therapies, and inflammatory pathologies.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Materials Science, Multidisciplinary

Tumor extracellular matrix-targeted nanoscavengers reverse suppressive microenvironment for cocktail therapy

Xiaokai Chen et al.

Summary: In this study, a multifunctional nanoscavenger was designed to clear tumor extracellular matrix, improve tumor hypoxia, and enhance photodynamic and immune therapies. This strategy provides a solution to overcome the suppressive tumor microenvironment.

MATERIALS TODAY (2022)

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Article Optics

Cerium-based nanoparticles for cancer photodynamic therapy

Hui Li et al.

Summary: This review discusses the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer photodynamic therapy (PDT), including the activation mechanisms for electron transfer to generate singlet oxygen. The types of cerium-based nanoparticles used for cancer PDT are summarized, and the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES (2022)

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Article Pharmacology & Pharmacy

Co-Delivery of Dihydroartemisinin and Indocyanine Green by Metal-Organic Framework-Based Vehicles for Combination Treatment of Hepatic Carcinoma

Yang Chen et al.

Summary: This study designed a nano-delivery system to co-load Dihydroartemisinin (DHA) and indocyanine green (ICG), and demonstrated that the combination therapy using this system could efficiently treat hepatic carcinoma. The research provides a potential nanodrug for the treatment of hepatic carcinoma.

PHARMACEUTICS (2022)

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Review Chemistry, Multidisciplinary

Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Yanling Hu et al.

Summary: Diabetic wound infection is a common disease that poses challenges due to the diabetic wound environment and bacterial resistance. Nanobiomaterial-based therapeutic systems with stimuli-responsive performance can address these challenges by delivering therapeutic agents on demand.

NANOSCALE (2022)

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Review Immunology

Redox regulation of the immune response

Gerwyn Morris et al.

Summary: The immune-inflammatory response is associated with increased nitro-oxidative stress. Redox-associated mechanisms play a crucial role in modulating various aspects of the immune response. Chronic nitro-oxidative stress can have detrimental effects on immune cells and their functions.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies

Xin Yan et al.

Summary: Loss of NOXA, a BCL2 family protein, was identified as a key regulator of resistance to CAR T-cell therapy. Low NOXA expression was associated with worse survival in patients with B-cell lymphoma. In vitro and in vivo experiments showed that enhancing NOXA expression using HDAC inhibitors dramatically increased sensitivity of cancer cells to CAR T-cell clearance.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Biochemistry & Molecular Biology

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Changyu Gao et al.

Summary: This article introduces a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance, which exhibits satisfactory bactericidal performance against MRSA.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Oncology

Effects of statins on brain tumors: a review

Amir R. Afshari et al.

Summary: Statins, known for reducing cholesterol and improving cardiovascular risk, have shown promising antitumor properties in preclinical studies. They have the potential to enhance the treatment outcomes of various cancers, including GBM, by suppressing cell growth and promoting apoptosis. However, the clinical outcomes of statins on the survival of GBM patients remain controversial.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Engineering, Environmental

Photodynamic and photothermal co-driven CO-enhanced multi-mode synergistic antibacterial nanoplatform to effectively fight against biofilm infections

Xiaojun Cai et al.

Summary: A CO-enhanced multi-mode synergistic antibacterial nanoplatform (ICG&CO@G3KBPY) has been successfully developed to combat biofilm infections, with enhanced biofilm penetration, antibacterial activity, and anti-inflammatory effects. The platform rapidly generates CO under the co-driven effects of PTT and PDT, significantly improving the efficacy of biofilm eradication while alleviating inflammation caused by bacterial infection, PTT, and PDT. This study provides an efficient and safe multi-mode synergistic antibacterial strategy for treating biofilm infections.

CHEMICAL ENGINEERING JOURNAL (2021)

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Meeting Abstract Critical Care Medicine

GADOLINIUM-INDUCED CARDIOPULMONARY ARREST IN A 57-YEAR-OLD FEMALE

Chinazor Iwuaba et al.

CHEST (2021)

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Review Chemistry, Inorganic & Nuclear

Breaking the time and space limitation of point-of-care testing strategies: Photothermometric sensors based on different photothermal agents and materials

Mingming Wei et al.

Summary: Photothermometric sensing strategies have shown great potential in various chem/biosensing fields, offering advantages such as portability, low cost, high resolution, and high spatiotemporal controllability. These sensors based on photothermal materials can effectively overcome the limitations of traditional methods, opening up new possibilities in disease diagnosis, health management, and environmental monitoring.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement

Gutian Zhang et al.

Summary: This study presents a facile approach to co-deliver IR780 and GA using self-assembled albumin nanoparticles, which can relieve hypoxia and suppress Hsp for clinical application of cancer phototherapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Hamed Nosrati et al.

Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Biomimetic nanoparticles loading with gamabutolin-indomethacin for chemo/photothermal therapy of cervical cancer and anti-inflammation

Chang Xiao et al.

Summary: A pro-nanodrug complex designed with GSH and NIR responsive elements can enhance chemo-photothermal therapy for cervical cancer, with the assistance of indomethacin. This nanocomplex shows strong anti-tumor activity both in vitro and in vivo, leading to eradication of cervical tumors and significant extension of survival time in mice.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation

Zi-Hao Li et al.

Summary: This study developed platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high photothermal conversion efficiency, and antioxidative catalytic activity, providing a new paradigm for designing safe and efficient photothermal agents for complex tumor diseases. The PtPB nanozymes exhibited tunable LSPR frequency, significantly enhanced photothermal conversion efficiency, and good biosafety after intravenous injection. The experimental and theoretical results revealed the mechanisms behind the enhanced photothermal conversion efficiency of PtPB with tunable LSPR frequency.

ACS NANO (2021)

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Review Engineering, Environmental

Recent advances in the development of near-infrared organic photothermal agents

Lu Li et al.

Summary: NIR absorbing organic photothermal agents have low cytotoxicity and are promising candidates for clinical application in deep-tissue cancer treatment. Imaging-guided PTT and combination therapy methods have shown to be optimizable and have potential for development amidst current challenges.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Dual-Drug Backboned Polyprodrug with a Predefined Drug Combination for Synergistic Chemotherapy

Fangzhou Yu et al.

Summary: An innovative dual-drug delivery system was designed in this study to achieve precise drug release ratios and generate synergistic anticancer effects.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Engineering a Hydrogen-Sulfide-Based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy

Jie Li et al.

Summary: The gas-modulated photothermal immunogenicity strategy, which integrates a polysulfide-based hydrogen sulfide donor with a conjugated polymer, shows great potential in inhibiting tumor growth and limiting inflammation.

ADVANCED MATERIALS (2021)

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Article Metallurgy & Metallurgical Engineering

More severe toxicity of gold nanoparticles with rougher surface in mouse hippocampal neurons

Lin Xin et al.

Summary: The study showed that the shape of gold nanoparticles (GNPs) affects the voltage-dependent sodium channel and action potential of hippocampal CA1 neurons in mice. GNPs inhibited the sodium current amplitudes and shifted the voltage-dependence curve, leading to increased neuronal excitability and altered action potential properties. Nanoflower-shaped GNPs had the most significant effects on action potential properties, indicating that the neurotoxicity of GNPs is dependent on surface roughness.

JOURNAL OF CENTRAL SOUTH UNIVERSITY (2021)

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Article Biotechnology & Applied Microbiology

Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer

Qiaoqi Chen et al.

Summary: The combination of multiple therapeutic modalities in nano-targeted cell-based cocktail therapy shows promise in promoting tumor regression and combating metastasis/recurrence. This approach not only effectively targets tumor sites, but also triggers photothermal effects, induces in situ tumor eradication, enhances DC maturation, polarizes TAMs, and increases CTL infiltration, ultimately leading to significant inhibition of primary tumors and metastasis.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Near-infrared light-triggered nano-prodrug for cancer gas therapy

Runcong Liu et al.

Summary: Gas therapy as a new cancer treatment method has gained increasing attention in recent years. By using near-infrared light as a stimulus to trigger the release of gas molecules, it has achieved improved therapeutic efficacy and reduced side effects.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects

Xue Xie et al.

Summary: The study demonstrates that the designed single-component Prussian blue nanoparticles (PBs) prepared using a hydrothermal method exhibit good dispersion and stability, showing antioxidant and anti-inflammatory effects in vitro and in vivo without inducing an inflammatory response.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Editorial Material Medicine, General & Internal

Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy Comment

Mouldy Sioud

EBIOMEDICINE (2021)

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Article Chemistry, Multidisciplinary

Constructing an Acidic Microenvironment by MoS2 in Heterogeneous Fenton Reaction for Pollutant Control

Qingyun Yan et al.

Summary: This study introduces a MoS2 cocatalytic heterogeneous Fenton system that creates a stable acidic micro-environment for the circulation of Fe3+/Fe2+ under macroneutral conditions, leading to sustainable degradation of organic pollutants.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Dual mitigation of immunosuppression combined with photothermal inhibition for highly effective primary tumor and metastases therapy

Ju Huang et al.

Summary: This study introduces a novel immunotherapeutic strategy utilizing a specific nanoliposome combining photothermal therapy with immune induction methods to enhance immune response, reduce inhibitory factors, and effectively combat cancer.

BIOMATERIALS (2021)

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Review Chemistry, Inorganic & Nuclear

Recent advances in immunotherapy, immunoadjuvant, and nanomaterial-based combination immunotherapy

Benqing Zhou et al.

Summary: Cancer immunotherapy has become a major treatment modality, utilizing immunoadjuvants and nanoplatforms to enhance efficacy. Different types of immunotherapies can be divided into five categories, each with its own limitations.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Recent advances in enhanced chemodynamic therapy strategies

Qiwei Tian et al.

Summary: Chemodynamic therapy (CDT) is a novel therapeutic modality that aims to destroy cancer cells using Fenton reactions without external energy input. Various strategies have been explored to enhance the efficiency of CDT, including increasing the production, accelerating generation, and enhancing efficacy of hydroxyl radicals.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary

Liquid exfoliation of TiN nanodots as novel sonosensitizers for photothermal-enhanced sonodynamic therapy against cancer

Xianwen Wang et al.

Summary: In this study, ultra-small titanium nitride nanodots were synthesized for photothermal-enhanced sonodynamic therapy against cancer. These nanodots exhibit promising multifunctional properties, combining the advantages of photothermal therapy and sonodynamic therapy for significant synergistic treatment effects on tumors. Importantly, these nanodots can be promptly metabolized from the body, reducing concerns about long-term toxicity.

NANO TODAY (2021)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Use of Intravenous Gadolinium-based Contrast Media in Patients with Kidney Disease and the Risk of Nephrogenic Systemic Fibrosis: Radiology In Training

Mostafa Alabousi et al.

Summary: A 66-year-old male patient with end-stage chronic kidney disease developed nephrogenic systemic fibrosis after receiving intravenous GBCM, highlighting the importance of carefully considering the use of contrast media in patients with kidney disease. The article provides a summary of evidence and recommendations for the use of intravenous GBCM in patients with kidney disease.

RADIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Ultrathin Two-Dimensional Plasmonic PtAg Nanosheets for Broadband Phototheranostics in Both NIR-I and NIR-II Biowindows

Ying Zhang et al.

Summary: This study discovered ultrathin two-dimensional plasmonic PtAg nanosheets with strong broadband light absorption from NIR-I to NIR-II biowindow, exhibiting outstanding photothermal and photoacoustic effects under both 785 and 1064 nm lasers. Functionalized PtAg nanosheets showed good biocompatibility and tumor-targeted function in vivo, achieving effective tumor ablation through photoacoustic imaging (PAI) and photothermal therapy (PTT).

ADVANCED SCIENCE (2021)

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Article Materials Science, Biomaterials

A rational study of the influence of Mn2+-insertion in Prussian blue nanoparticles on their photothermal properties

Maelle Cahu et al.

Summary: Through a one-step self-assembly reaction, Mn2+ can replace up to 32% of Fe3+ in the Prussian blue structure, with higher proportions resulting in a different structure. The photothermal conversion efficiency of the nanoparticles is dependent on the Mn/Na-Mn-Fe ratio and nanoparticle concentration. Evaluation on MDA-MB-231 cells confirmed the excellent photothermal efficiency of these nanoparticles.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Biochemistry & Molecular Biology

Inflammation and tumor progression: signaling pathways and targeted intervention

Huakan Zhao et al.

Summary: Inflammation plays a crucial role in cancer development and therapy, either promoting or inhibiting tumor progression and therapeutic outcomes. Various signaling pathways and factors have been identified as pivotal regulators of inflammation initiation and resolution.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

Metabolic barriers to cancer immunotherapy

Kristin DePeaux et al.

Summary: The tumour microenvironment creates barriers that suppress immune responses, including physical barriers, recruitment of suppressive immune cells, and upregulation of inhibitory ligands on tumour cells. Therapies targeting metabolic restrictions in the tumour microenvironment show promise for combination therapies against various types of cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

Xue Xie et al.

Summary: The study found that PBzyme has potential anti-oxidative and anti-inflammatory effects in the prophylactic treatment of AP, possibly involving inhibition of signaling pathways and scavenging reactive oxygen species. This provides a foundation for the clinical application of PBzyme in the preventive treatment of AP.

THERANOSTICS (2021)

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Article Engineering, Biomedical

Zn2+ Doped Ultrasmall Prussian Blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance

Pingbo Shou et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

Chao Fang et al.

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Article Chemistry, Analytical

Manganese ion chelated FeOCl@PB@PDA@BPQDs nanocomposites as a tumor microenvironment-mediated nanoplatform for enhanced tumor imaging and therapy

Ming Zhang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Triggered Ion Exchange of a Metal-Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Ying Chen et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Copper-Enriched Prussian Blue Nanomedicine for In Situ Disulfiram Toxification and Photothermal Antitumor Amplification

Wencheng Wu et al.

ADVANCED MATERIALS (2020)

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Review Multidisciplinary Sciences

Strategies for engineering advanced nanomedicines for gas therapy of cancer

Yingshuai Wang et al.

NATIONAL SCIENCE REVIEW (2020)

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Review Chemistry, Multidisciplinary

Toxicity of metal and metal oxide nanoparticles: a review

Ayse Busra Sengul et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2020)

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Review Medicine, General & Internal

Stimuli -responsive prodrug-based cancer nanomedicine

Angel Xie et al.

EBIOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence

Tianjun Zhou et al.

ACS NANO (2020)

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Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Chemistry, Inorganic & Nuclear

Multifunctional Prussian blue-based nanomaterials: Preparation, modification, and theranostic applications

Xianwen Wang et al.

COORDINATION CHEMISTRY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Metallic 1T Phase Enabling MoS2 Nanodots as an Efficient Agent for Photoacoustic Imaging Guided Photothermal Therapy in the Near-Infrared-II Window

Zhan Zhou et al.

SMALL (2020)

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Review Biochemistry & Molecular Biology

Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

Dorien Clarisse et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Article Materials Science, Biomaterials

Dual-Key-and-Lock dual drug carrier for dual mode imaging guided chemo-photothermal therapy

Feng Tian et al.

BIOMATERIALS SCIENCE (2020)

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Article Materials Science, Biomaterials

An acidity-responsive polyoxometalate with inflammatory retention for NIR-II photothermal-enhanced chemodynamic antibacterial therapy

Yunhao Shi et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Tuning molecular aggregation to achieve highly bright AIE dots for NIR-II fluorescence imaging and NIR-I photoacoustic imaging

Yanzi Xu et al.

CHEMICAL SCIENCE (2020)

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Article Pharmacology & Pharmacy

Prussian Blue@Polyacrylic Acid/Au Aggregate Janus Nanoparticles for CT Imaging-guided Chemotherapy and Enhanced Photothermal Therapy

Dan Li et al.

ADVANCED THERAPEUTICS (2020)

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Article Materials Science, Biomaterials

Ultra-small Bi2S3 nanodot-doped reversible Fe(ii/iii)-based hollow mesoporous Prussian blue nanocubes for amplified tumor oxidative stress-augmented photo-/radiotherapy

Chuchu Ren et al.

BIOMATERIALS SCIENCE (2020)

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Article Astronomy & Astrophysics

The Effects of Dust Optical Properties on the Scattering-induced Disk Polarization by Millimeter-sized Grains

Haifeng Yang et al.

ASTROPHYSICAL JOURNAL (2020)

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Review Materials Science, Multidisciplinary

Nanomaterials as photothermal therapeutic agents

Junqi Chen et al.

PROGRESS IN MATERIALS SCIENCE (2019)

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Review Chemistry, Multidisciplinary

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Physical

Visual dual chemodynamic/photothermal therapeutic nanoplatform based on superoxide dismutase plus Prussian blue

Shan Lei et al.

NANO RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Molecular Imaging in the Second Near-Infrared Window

Hao Wan et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Generating New Cross-Relaxation Pathways by Coating Prussian Blue on NaNdF4 To Fabricate Enhanced Photothermal Agents

Zhongzheng Yu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Immunology

Modulating inflammation for cancer therapy

Birgit Ritter et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Thermal-Responsive Carbon Monoxide (CO) Delivery Expedites Metabolic Exhaustion of Cancer Cells toward Reversal of Chemotherapy Resistance

Yongjuan Li et al.

ACS CENTRAL SCIENCE (2019)

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Article Nanoscience & Nanotechnology

Enhanced Plasmon-Induced Resonance Energy Transfer (PIRET)-Mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging

Tao Zheng et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Cancer Immunotherapy: Designing Bioinspired 2D MoSe 2 Nanosheet for Efficient Photothermal‐Triggered Cancer Immunotherapy with Reprogramming Tumor‐Associated Macrophages (Adv. Funct. Mater. 30/2019)

Lizhen He et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Engineering, Biomedical

Carbon monoxide (CO)-Strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction

Yongjuan Li et al.

BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Augment of Oxidative Damage with Enhanced Photodynamic Process and MTH1 Inhibition for Tumor Therapy

Jing-Jing Hu et al.

NANO LETTERS (2019)

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Article Multidisciplinary Sciences

Metal-organic frameworks with photocatalytic bactericidal activity for integrated air cleaning

Ping Li et al.

NATURE COMMUNICATIONS (2019)

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Article Engineering, Biomedical

A novel NIR-controlled NO release of sodium nitroprusside-doped Prussian blue nanoparticle for synergistic tumor treatment

Tao Feng et al.

BIOMATERIALS (2019)

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Article Multidisciplinary Sciences

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

Ardeshir R. Rastinehad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Nanoscience & Nanotechnology

Au@Prussian Blue Hybrid Nanomaterial Synergy with a Chemotherapeutic Drug for Tumor Diagnosis and Chemodynamic Therapy

Lifeng Hang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Meeting Abstract Oncology

Unplanned hospital admission in patients receiving concurrent chemotherapy and radiation.

Nicholas Damico et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Materials Science, Multidisciplinary

Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors

Qian Cheng et al.

NPG ASIA MATERIALS (2019)

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Article Biotechnology & Applied Microbiology

Intracellular tracking of drug release from pH-sensitive polymeric nanoparticles via FRET for synergistic chemo-photodynamic therapy

Chen Du et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione AND H2O2 Sequentially Triggered Chemodynamic Therapy

Baojin Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Materials Science, Multidisciplinary

A skin-over-liquid platform with compliant microbumps actuated by pyro-EHD pressure

O. Gennari et al.

NPG ASIA MATERIALS (2019)

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Review Pharmacology & Pharmacy

Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles

Jinsong Tao et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Article Chemistry, Multidisciplinary

Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f

Meng Zhang et al.

MATERIALS HORIZONS (2019)

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Review Biology

Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?

Stuart K. Calderwood

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)

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Article Nanoscience & Nanotechnology

Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice

Jiulong Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy

Jun Zhou et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles

Jinyoung Kang et al.

ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

Chuan Hu et al.

BIOMATERIALS (2018)

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Review Engineering, Biomedical

Progress in Applications of Prussian Blue Nanoparticles in Biomedicine

Zhiguo Qin et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Materials Science, Biomaterials

A fullerene-rhodamine B photosensitizer with pH-activated visible-light absorbance/fluorescence/photodynamic therapy

Qianyun Tang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Chemistry, Multidisciplinary

Gas-Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

Luodan Yu et al.

ADVANCED MATERIALS (2018)

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Review Pharmacology & Pharmacy

Prussian blue nanoparticles: Synthesis, surface modification, and application in cancer treatment

Milan Gautam et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Meeting Abstract Oncology

Phase I/II study of laser interstitial thermotherapy (LITT) combined with checkpoint inhibitor for recurrent glioblastoma (rGBM).

Andrew E. Sloan et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Chemistry, Multidisciplinary

Self-Supplied Tumor Oxygenation through Separated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy of Cancer

Xuejiao Song et al.

NANO LETTERS (2018)

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Article Multidisciplinary Sciences

Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread

Qiaoli Ma et al.

SCIENCE ADVANCES (2018)

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Review Chemistry, Multidisciplinary

Acoustogenic Probes: A New Frontier in Photoacoustic Imaging

Hailey J. Knox et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Glucose-Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving-Like/Gas Therapy

Wenpei Fan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Chemistry, Multidisciplinary

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual-Modal Imaging-Guided PhotothermalChemotherapy of Triple Negative Breast Cancer

Wei Tian et al.

ADVANCED SCIENCE (2017)

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Review Chemistry, Multidisciplinary

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Dalong Ni et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Engineering, Biomedical

Enhanced photothermal therapy of biomimetic polypyrrole nanoparticles through improving blood flow perfusion

Xuejun Wang et al.

BIOMATERIALS (2017)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Polydopamine-Coated Lanthanide Nanoparticles for NIR-II/CT Dual Imaging and Photothermal Therapy

Yu Dai et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Review Oncology

Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potential

Cun Wang et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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Article Nanoscience & Nanotechnology

Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents

Byeongsu Kwon et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Chemistry, Multidisciplinary

Enabling Prussian Blue with Tunable Localized Surface Plasmon Resonances: Simultaneously Enhanced Dual-Mode Imaging and Tumor Photothermal Therapy

Xiaojun Cai et al.

ACS NANO (2016)

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Article Engineering, Biomedical

Near infrared light responsive hybrid nanoparticles for synergistic therapy

Yan Liang et al.

BIOMATERIALS (2016)

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Article Chemistry, Multidisciplinary

Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

Wei Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Article Chemistry, Multidisciplinary

A Versatile Nanotheranostic Agent for Efficient Dual-Mode Imaging Guided Synergistic Chemo-Thermal Tumor Therapy

Xiaojun Cai et al.

ADVANCED FUNCTIONAL MATERIALS (2015)

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Review Chemistry, Multidisciplinary

Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Kenneth K. Ng et al.

CHEMICAL REVIEWS (2015)

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Article Chemistry, Multidisciplinary

S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes

Ryo Kinoshita et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Physiology

Carbon monoxide and mitochondria-modulation of cell metabolism, redox response and cell death

Ana S. Almeida et al.

FRONTIERS IN PHYSIOLOGY (2015)

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Review Oncology

Estimates of benefits and harms of prophylactic use of aspirin in the general population

J. Cuzick et al.

ANNALS OF ONCOLOGY (2015)

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Article Engineering, Biomedical

PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy

Liang Cheng et al.

BIOMATERIALS (2014)

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Review Oncology

Cancer-related inflammation and treatment effectiveness

Connie I. Diakos et al.

LANCET ONCOLOGY (2014)

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Article Chemistry, Multidisciplinary

Prussian blue nanoparticles for laser-induced photothermal therapy of tumors

Hilary A. Hoffman et al.

RSC ADVANCES (2014)

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Review Chemistry, Multidisciplinary

Nano-Sized CT Contrast Agents

Nohyun Lee et al.

ADVANCED MATERIALS (2013)

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Review Oncology

Nanooncology: The Future of Cancer Diagnosis and Therapy

Avnesh S. Thakor et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2013)

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Review Radiology, Nuclear Medicine & Medical Imaging

Tumor Ablation: Common Modalities and General Practices

Erica M. Knavel et al.

TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY (2013)

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Article Chemistry, Multidisciplinary

Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy

Guanglei Fu et al.

CHEMICAL COMMUNICATIONS (2012)

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Article Chemistry, Multidisciplinary

Copper Selenide Nanocrystals for Photothermal Therapy

Colin M. Hessel et al.

NANO LETTERS (2011)

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Article Biochemistry & Molecular Biology

Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

Makoto Mitsunaga et al.

NATURE MEDICINE (2011)

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Article Biochemistry & Molecular Biology

Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

Xiaosong Li et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2011)

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Review Chemistry, Multidisciplinary

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

Jonathan P. Celli et al.

CHEMICAL REVIEWS (2010)

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Review Biochemistry & Molecular Biology

The Heat Shock Response: Life on the Verge of Death

Klaus Richter et al.

MOLECULAR CELL (2010)

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Article Immunology

NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Jurg Tschopp et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

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Article Multidisciplinary Sciences

Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction

NWS Kam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Oncology

CT-guided interstitial brachytherapy of liver malignancies alone or in combination with thermal ablation:: Phase I-II results of a novel technique

J Ricke et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

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