4.5 Review

Recent advances in Prussian blue-based photothermal therapy in cancer treatment

期刊

BIOMATERIALS SCIENCE
卷 11, 期 13, 页码 4411-4429

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d3bm00509g

关键词

-

向作者/读者索取更多资源

Malignant tumors pose a serious threat to human health. Traditional chemotherapy has achieved breakthrough improvements, but it also has significant side effects such as drug resistance, immunosuppression, and systemic toxicity. Photothermal therapy (PTT), an emerging cancer therapy, uses light irradiation to convert optical energy into thermal energy and induce hyperthermic death of target cells. Prussian blue (PB) nanoparticles are among the most promising photothermal agents due to their excellent physicochemical properties. By constructing PB-based nanotherapeutics, enhanced photothermal performance, targeting ability, multimodal therapy, and imaging-guided cancer therapy can be effectively achieved. This review comprehensively summarizes the recent advances in PB-based photothermal combinatorial therapy and imaging-guided cancer therapy, and discusses potential obstacles for future research and clinical translation.
Malignant tumours are a serious threat to human health. Traditional chemotherapy has achieved breakthrough improvements but also has significant detrimental effects, such as the development of drug resistance, immunosuppression, and even systemic toxicity. Photothermal therapy (PTT) is an emerging cancer therapy. Under light irradiation, the phototherapeutic agent converts optical energy into thermal energy and induces the hyperthermic death of target cells. To date, numerous photothermal agents have been developed. Prussian blue (PB) nanoparticles are among the most promising photothermal agents due to their excellent physicochemical properties, including photoacoustic and magnetic resonance imaging properties, photothermal conversion performance, and enzyme-like activity. By the construction of suitably designed PB-based nanotherapeutics, enhanced photothermal performance, targeting ability, multimodal therapy, and imaging-guided cancer therapy can be effectively and feasibly achieved. In this review, the recent advances in PB-based photothermal combinatorial therapy and imaging-guided cancer therapy are comprehensively summarized. Finally, the potential obstacles of future research and clinical translation are discussed.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据