期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 28, 期 3, 页码 -出版社
IMR PRESS
DOI: 10.31083/j.fbl2803061
关键词
mitochondrial coenzyme Q (mtQ); mtQ redox state; mtQ pool size; mtQ homeostasis; mtQ-reducing and QH2-oxidizing pathways; reactive oxygen species formation
Mitochondrial coenzyme Q (mtQ) is a redox active carrier involved in electron transfer and mitochondrial reactive oxygen species (mtROS) formation. The redox state of the mtQ pool reflects mitochondrial bioenergetic activity and oxidative stress. This study provides an overview of the factors affecting mtQ redox homeostasis and its relationship to mtROS production. The level of mtQ reduction may be a useful marker for assessing mtROS formation, which is influenced by the size of the mtQ pool and the activity of respiratory chain pathways.
Mitochondrial coenzyme Q (mtQ) of the inner mitochondrial membrane is a redox active mobile carrier in the respiratory chain that transfers electrons between reducing dehydrogenases and oxidizing pathway(s). mtQ is also involved in mitochondrial reactive oxygen species (mtROS) formation through the mitochondrial respiratory chain. Some mtQ-binding sites related to the respiratory chain can directly form the superoxide anion from semiubiquinone radicals. On the other hand, reduced mtQ (ubiquinol, mtQH2) recycles other antioxidants and directly acts on free radicals, preventing oxidative modifications. The redox state of the mtQ pool is a central bioener-getic patameter that alters in response to changes in mitochondrial function. It reflects mitochondrial bioenergetic activity and mtROS formation level, and thus the oxidative stress associated with the mitochondria. Surprisingly, there are few studies describing a direct relationship between the mtQ redox state and mtROS production under physiological and pathological conditions. Here, we provide a first overview of what is known about the factors affecting mtQ redox homeostasis and its relationship to mtROS production. We have proposed that the level of reduction (the endogenous redox state) of mtQ may be a useful indirect marker to assess total mtROS forma-tion. A higher mtQ reduction level (mtQH2/mtQtotal) indicates greater mtROS formation. The mtQ reduction level, and thus the mtROS formation, depends on the size of the mtQ pool and the activity of the mtQ-reducing and mtQH2-oxidizing pathway(s) of respiratory chain. We focus on a number of physiological and pathophysiological factors affecting the amount of mtQ and thus its redox homeostasis and mtROS production level.
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