期刊
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
卷 38, 期 1, 页码 -出版社
SPRINGER
DOI: 10.1007/s00384-023-04410-z
关键词
Ulcerative colitis-associated carcinoma; Surgery; Recurrence
This study investigated the risk factors for recurrent ulcerative colitis-associated colorectal cancer (UC-CRC). The significant risk factors for recurrence were age at surgery, undifferentiated carcinoma, lymph node metastasis, and vascular invasion. Young adult patients with stage III CRC had a worse prognosis.
PurposeAlthough ulcerative colitis-associated colorectal cancer (UC-CRC) has been described, there are few reports regarding recurrent cases of UC-CRC. In this study, we investigated the risk factors for UC-CRC recurrence.MethodsRecurrence-free survival (RFS) was determined for 144 stage I to III cancer patients among 210 UC-CRC patients from August 2002 to August 2019. The Kaplan-Meier method was used to obtain the cumulative RFS rate, and the Cox proportional hazard model was used to extract recurrence risk factors. The interaction term between cancer stage and prognostic factors specific to UC-CRC was evaluated using the Cox model. The Kaplan-Meier method was applied by cancer stage to the UC-CRC-specific prognostic factors for which interaction effects were indicated.ResultsThere were 18 cases of recurrence involving patients with stage I to III cancer, and the recurrence rate was 12.5%. The cumulative 5-year RFS rate was 87.5%. Multivariable analysis showed that age at surgery (hazard ratio (HR): 0.95, 95% CI: 0.91-0.99, p = 0.02), undifferentiated carcinoma (HR: 4.42, 95% CI: 1.13-17.24, p = 0.03), lymph node metastasis (HR: 4.11, 95% CI: 1.08-15.69, p = 0.03), and vascular invasion (HR: 8.01, 95% CI: 1.54-41.65, p = 0.01) were significant risk factors for recurrence. Patients with stage III CRC in the young adult (age < 50 years) group had a significantly worse prognosis than those in the adult (age >= 50 years) group (p < 0.01).ConclusionAge at surgery was identified as a risk factor for UC-CRC recurrence. Young adult patients with stage III cancer may have a poor prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据