期刊
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
卷 17, 期 6, 页码 613-621出版社
OXFORD UNIV PRESS
DOI: 10.1093/ehjci/jew005
关键词
hypertrophic cardiomyopathy; ventricular arrhythmia; strain echocardiography and cardiac magnetic resonance
资金
- Center for Cardiological Innovation
- Research Council of Norway
- Simon Fougner Hartmann's family foundation
- National Association for Public Health, Norway
Aims Hypertrophic cardiomyopathy (HCM) patients are at risk of ventricular arrhythmias (VAs). We aimed to explore whether systolic function by strain echocardiography is related to VAs and to the extent of fibrosis by cardiac magnetic resonance imaging (CMR). Methods and results We included 150 HCM patients and 50 healthy individuals. VAs were defined as non-sustained and sustained ventricular tachycardia and aborted cardiac arrest. Left ventricular function was assessed by ejection fraction (EF) and by global longitudinal strain (GLS) assessed by speckle tracking echocardiography. Mechanical dispersion was calculated as standard deviation (SD) of time from Q/R on ECG to peak longitudinal strain in 16 left ventricular segments. Late gadolinium enhancement (LGE) was assessed by CMR. HCM patients had similar EF (61 +/- 5% vs. 61 +/- 8%, P = 0.77), but worse GLS (-15.7 +/- 3.6% vs. -21.1 +/- 1.9%, P < 0.001) and more pronounced mechanical dispersion (64 +/- 22 vs. 36 +/- 13 ms, P < 0.001) compared with healthy individuals. VAs were documented in 37 (25%) HCM patients. Patients with VAs had worse GLS (-14.1 +/- 3.6% vs. -16.3 +/- 3.4%, P < 0.01), more pronounced mechanical dispersion (79 +/- 27 vs. 59+ 16 ms, P, 0.001), and higher %LGE (6.1 +/- 7.8% vs. 0.5 +/- 1.4%, P < 0.001) than patients without VAs. Mechanical dispersion correlated with %LGE (R = 0.52, P < 0.001) and was independently associated with VAs (OR 1.6, 95% CI 1.1-2.3, P = 0.02) and improved risk stratification for VAs. Conclusion GLS, mechanical dispersion, and LGE were markers of VAs in HCM patients. Mechanical dispersion was a strong independent predictor of VAs and related to the extent of fibrosis. Strain echocardiography may improve risk stratification of VAs in HCM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据