Photocatalytic C-N cross-coupling mediated by heterogeneous nickel-coordinated carbon nitride

An easy to prepare nickel-coordinated mesoporous graphitic carbon nitride (Ni-mpg-CN) was introduced as a heterogeneous photocatalyst, which efficiently accelerated the photocatalytic C-N cross-coupling of (hetero)aryl bromides and aliphatic amines, delivering the desired monoaminated products in good yields. In addition, the concise synthesis of the pharmaceutical tetracaine was accomplished in the final stage, further highlighting the practical applicability.

Automated summary

An easy to prepare nickel-coordinated mesoporous graphitic carbon nitride (Ni-mpg-CN) was used as a heterogeneous photocatalyst to efficiently catalyze the photocatalytic C-N cross-coupling of (hetero)aryl bromides and aliphatic amines, yielding the desired monoaminated products in good yields. Furthermore, the synthesis of the pharmaceutical tetracaine was successfully achieved, highlighting its practical applicability.