Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD concept

Summary: To effectively control and prevent the COVID-19 pandemic, suitable vaccines have been rapidly researched and developed. However, the emergence of highly transmissible variants and their ability to escape vaccine-generated immune responses pose challenges to vaccine effectiveness. Evaluating the efficiency of new COVID-19 vaccines based on different technology platforms is necessary, but selecting suitable populations for clinical trials is challenging. Establishing surrogate endpoints based on neutralizing antibody titers could facilitate vaccine research and development.

Summary: A study quantified the global impact of the first year of COVID-19 vaccination programs, finding that the vaccination has substantially altered the course of the pandemic, saving tens of millions of lives globally. However, inadequate access to vaccines in low-income countries has limited the impact, reinforcing the need for global vaccine equity and coverage.

Summary: The study estimated that COVID-19 vaccination has prevented millions of deaths globally between December 8, 2020, and December 8, 2021. Achieving the vaccination coverage targets set by COVAX and WHO could have prevented even more deaths. However, limited access to vaccines in low-income countries has hindered the impact, highlighting the importance of global vaccine equity.