SLC11A2: a promising biomarker and therapeutic target in ovarian cancer

Ovarian cancer has the highest mortality rate among gynecologic tumors, with a 5-year survival rate of less than 25%. There is an urgent need for early diagnosis and new drugs to reduce the disease burden of ovarian cancer. The aim of this study was to investigate the effectiveness of SLC11A2 as a therapeutic target and marker for ovarian cancer. Expression data of SLC11A2 were obtained from public databases. Then, the biological functions of SLC11A2 were validated in four ovarian cancer cell lines. Finally, we collected ovarian cancer clinical tissues, serum, and plasma exosomes and used immunohistochemistry, Elisa, and liquid chromatography-mass spectrometry (LC-MS) to validate the test efficacy of SLC11A2. The results showed that ovarian cancers with high SLC11A2 mRNA expression had shorter 5-year PFS and MST. Knockdown of SLC11A2 reduced ovarian cancer migration and increased cisplatin-induced apoptosis. Serum SLC11A2 may help improve the detection rate of ovarian cancer.

Automated summary

Ovarian cancer has a high mortality rate and requires early diagnosis and new drugs. This study investigated the effectiveness of SLC11A2 as a therapeutic target and marker for ovarian cancer. Expression data, biological function validation, and test efficacy validation of SLC11A2 were conducted. Results showed that high expression of SLC11A2 was associated with shorter survival rates and increased cancer migration. Serum SLC11A2 may improve the detection rate of ovarian cancer.