Concerns about the health and environmental effects of current sunscreens have led to the search for safer and more efficient alternatives from natural sources. However, current improvements in sunscreens involve complex formulations and expensive nanotechnologies, making them impractical. In this study, a simple and efficient strategy utilizing naturally reproducible tea polyphenols was used to create a biocompatible, antioxidative and light-colored sunscreen with only UVB absorption. The resulting nanoparticle-based sunscreen demonstrated strong antioxidative activity, good anti-UV performance and photostability, and provided effective protection against photodamage.
The concerns about the health and environmental effects of the active ingredients in current sunscreens have spurred the enthusiasm for seeking out biosafe and efficient alternatives, especially from nature. However, the present improvement is generally associated with multistep, expensive nanotechnologies and complex formulations of multiple active ingredients for achieving efficient ultraviolet (UV) protection, and the absence of antioxidative activity and the dark color further hinder the practical application of these naturally sourced absorbers. Herein, a facile and efficient strategy is introduced to prepare a biocompatible, antioxidative and light-colored sunscreen solely from naturally reproducible tea polyphenols with only UVB absorption. We demonstrate that the Mannich condensation assembly of polyphenol nanoparticles gave rise to broadband UV shielding and enhanced extinction efficacy. These nanoparticles have strong antioxidative activities and offer a wide range of selections for particle-stabilized emulsion formulations with a cosmetically acceptable appearance and, most importantly, with good anti-UV performance and photostability under UV exposure. Favorable UV protection against inflammation, epidermal hyperplasia, and hyperkeratosis was achieved in an acute photodamage model. The particle-stabilized emulsions are also adhesive, water-resistant and comfortable to apply. This study lays the foundation for formulating polyphenol-based sunscreens, and the acquisition of broadband UV protection by molecular assembly of a UVB absorber is validated as an effective strategy to be beneficial for future UV absorber development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据