The Role of Nephrologists in the Management of Methanol Poisoning

Acute methanol poisoning is a rare but serious condition that can lead to significant morbidity and mortality. Toxic metabolites produced by methanol, primarily formaldehyde, can cause high anion gap metabolic acidosis, with the severity of clinical presentation ranging from mild symptoms to multi-organ failure. Nine people died and four patients needed treatment at our university hospital following a collective intoxication caused by the consumption of homemade alcoholic beverages in the central region of Morocco. The four patients presented to the emergency department with varying clinical symptoms, such as decreased visual acuity, severe agitation, and dyspnea. The laboratory tests confirmed high anion gap metabolic acidosis and a subsequent toxicology screen revealed that they had consumed methanol-tainted alcohol. The treatment regimen involved inhibiting the formation of toxic metabolites using an antidote (ethanol or fomepizole), correcting metabolic acidosis, enhancing the elimination of toxic metabolites through prolonged hemodialysis, and administering adjunctive therapies. While two patients had favorable outcomes, the other two died from multi-organ failure. These findings highlight the importance of prompt diagnosis and treatment in cases of methanol poisoning.

Automated summary

Acute methanol poisoning is a rare but serious condition that can result in significant morbidity and mortality. It is caused by toxic metabolites produced by methanol, primarily formaldehyde, which can lead to high anion gap metabolic acidosis. Prompt diagnosis and treatment are crucial in such cases to prevent multi-organ failure and improve outcomes. This study highlights the importance of early intervention and provides insights into the treatment regimen for methanol poisoning.