Clinical implications of myeloid malignancy-related somatic mutations in aplastic anemia

Editorial Material Medicine, General & Internal

A New Standard Immunosuppression Regimen in Severe Aplastic Anemia

Phillip Scheinberg

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Medicine, General & Internal

Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

R. Peffault de Latour et al.

Summary: Eltrombopag improves the efficacy of standard immunosuppressive therapy for severe aplastic anemia, leading to higher complete response rates within 3 months.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Multidisciplinary Sciences

The longitudinal dynamics and natural history of clonal haematopoiesis

Margarete A. Fabre et al.

Summary: Clonal haematopoiesis, a common phenomenon in human tissues during aging, was studied by tracking 697 clones from 385 individuals aged 55 years or older over a median of 13 years. The study found that 92.4% of the clones expanded at a stable exponential rate, with different mutations driving different growth rates. Clones with the same mutation had growth rates differing by approximately +/- 5% per year. The study also revealed that mutations driving faster clonal growth carried a higher risk of malignant progression.

NATURE (2022)

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Article Oncology

Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia

Emma M. Groarke et al.

Summary: This study assessed predictors, genetic characteristics, and long-term outcomes of patients with severe aplastic anemia (SAA) who experienced clonal evolution after immunosuppressive therapy (IST). High-risk evolution was associated with older age and higher ANC levels. Patients with high-risk clonal evolution had lower overall survival rates, but those who underwent hematopoietic stem cell transplant (HSCT) showed improved survival. Certain gene mutations detected at 6 months after IST were predictive of high-risk evolution.

LEUKEMIA (2022)

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Article Hematology

Clonality in immune aplastic anemia: Mechanisms of immune escape or malignant transformation

Jibran Durrani et al.

Summary: Aplastic anemia is a bone marrow failure syndrome that can be inherited or acquired. Inherited forms are caused by germline mutations, while acquired forms are thought to result from immune attack on hematopoietic stem cells. Chromosomal abnormalities and genetic variations have been found in aplastic anemia, indicating clonality. This review discusses the current concepts of clonality, somatic mutations, and their impact on diagnosis and clinical outcomes in immune aplastic anemia.

SEMINARS IN HEMATOLOGY (2022)

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Review Hematology

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria

Lova Sun et al.

BLOOD (2020)

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Review Oncology

Prognostic value and clinical feature of SF3B1 mutations in myelodysplastic syndromes: A meta-analysis

Yaqiong Tang et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

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Article Hematology

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

Thomas Winkler et al.

BLOOD (2019)

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Review Hematology

Molecular pathogenesis of acquired aplastic anemia

Prajwal C. Boddu et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2019)

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Article Hematology

Immunosuppressive therapy with rabbit antithymocyte globulin therapy for acquired aplastic anemia: a multi-institutional retrospective study in Japanese adult patients

Nana Sasaki et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2019)

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Review Oncology

New Insights from Studies of Clonal Hematopoiesis

Christopher J. Gibson et al.

CLINICAL CANCER RESEARCH (2018)

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Article Oncology

Somatic Mutations in Aplastic Anemia

Ghulam J. Mufti et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2018)

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Review Hematology

Aplastic anemia: Etiology, molecular pathogenesis, and emerging concepts

Rory M. Shallis et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2018)

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Review Medicine, General & Internal

Aplastic Anemia

Neal S. Young

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Education, Scientific Disciplines

A brief, but comprehensive, guide to clonal evolution in aplastic anemia

Daria V. Babushok

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2018)

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Article Education, Scientific Disciplines

Clinical implications of somatic mutations in aplastic anemia and myelodysplastic syndrome in genomic age

Jaroslaw P. Maciejewski et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2017)

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Article Hematology

Clonality in context: hematopoietic clones in their marrow environment

James N. Cooper et al.

BLOOD (2017)

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Letter Hematology

Origins of myelodysplastic syndromes after aplastic anemia

Eiju Negoro et al.

BLOOD (2017)

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Article Hematology

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

Manuel Buscarlet et al.

BLOOD (2017)

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Article Hematology

Telomere length and somatic mutations in correlation with response to immunosuppressive treatment in aplastic anaemia

Hee S. Park et al.

BRITISH JOURNAL OF HAEMATOLOGY (2017)

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Article Hematology

Clinical significance of somatic mutation in unexplained blood cytopenia

Luca Malcovati et al.

BLOOD (2017)

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Review Hematology

Recent advances in understanding clonal haematopoiesis in aplastic anaemia

Natasha Stanley et al.

BRITISH JOURNAL OF HAEMATOLOGY (2017)

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Article Hematology

Guidelines for the diagnosis and management of adult aplastic anaemia

Sally B. Killick et al.

BRITISH JOURNAL OF HAEMATOLOGY (2016)

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Review Hematology

Clonal hematopoiesis in acquired aplastic anemia

Seishi Ogawa

BLOOD (2016)

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Review Hematology

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

Daniel A. Arber et al.

BLOOD (2016)

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Review Biotechnology & Applied Microbiology

Mutations of myelodysplastic syndromes (MDS): An update

Bani Bandana Ganguly et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2016)

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Letter Hematology

Mutations of ASXL1 and TET2 in aplastic anemia

Jinbo Huang et al.

HAEMATOLOGICA (2015)

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Article Medicine, General & Internal

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

T. Yoshizato et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Oncology

Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

Dana V. Babushok et al.

CANCER GENETICS (2015)

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Letter Hematology

Mutations of ASXL1 and TET2 in aplastic anemia

Jinbo Huang et al.

HAEMATOLOGICA (2015)

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Article Hematology

Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome

Austin G. Kulasekararaj et al.

BLOOD (2014)

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Letter Hematology

Genetic characterization of acquired aplastic anemia by targeted sequencing

Michael Heuser et al.

HAEMATOLOGICA (2014)

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Article Medicine, General & Internal

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

Giulio Genovese et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Medicine, General & Internal

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Hematology

Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia

Phillip Scheinberg et al.

BRITISH JOURNAL OF HAEMATOLOGY (2009)

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Article Medicine, General & Internal

Antithymocyte globulin and cyclosporine for severe aplastic anemia - Association between hematologic response and long-term outcome

S Rosenfeld et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

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Clinical implications of myeloid malignancy-related somatic mutations in aplastic anemia

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