4.2 Article

Semaglutide for the treatment of antipsychotic-associated weight gain in patients not responding to metformin - a case series

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes The STEP 8 Randomized Clinical Trial

Domenica M. Rubino et al.

Summary: In overweight or obese adults without diabetes, once-weekly subcutaneous semaglutide resulted in significantly greater weight loss compared to once-daily subcutaneous liraglutide when added to counseling for diet and physical activity over 68 weeks.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Review Medicine, Research & Experimental

Efficacy of GLP-1 RA Approved for Weight Management in Patients With or Without Diabetes: A Narrative Review

Mojca Jensterle et al.

Summary: The approval of once daily liraglutide, 3.0 mg, and once weekly semaglutide, 2.4 mg, for chronic weight management provides a novel effective strategy against obesity. However, people with diabetes show a weaker response to GLP-1 RAs compared to those without diabetes, potentially due to background medications promoting weight gain, fear of hypoglycemia, decrease in glycosuria and subsequent less weight loss, altered microbiota, and genetic predisposition to weight gain in diabetic patients.

ADVANCES IN THERAPY (2022)

Article Endocrinology & Metabolism

Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial

Takashi Kadowaki et al.

Summary: Semaglutide was found to be effective in weight management in obese individuals from east Asia, leading to significant reductions in bodyweight and abdominal visceral fat area. It represents a promising treatment option for weight management in this population.

LANCET DIABETES & ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as add-on to metformin in patients with type 2 diabetes in SUSTAIN China: A 30-week, double-blind, phase 3a, randomized trial

Linong Ji et al.

Summary: The study showed that once-weekly semaglutide was more effective than sitagliptin in improving glycemic control and reducing body weight in patients with type 2 diabetes inadequately controlled on metformin, with consistent efficacy and safety findings in the Chinese subpopulation.

DIABETES OBESITY & METABOLISM (2021)

Article Endocrinology & Metabolism

Effect of Orally Administered Semaglutide Versus Dulaglutide on Diabetes-Related Quality of Life in Japanese Patients with Type 2 Diabetes: The PIONEER 10 Randomized, Active-Controlled Trial

Hitoshi Ishii et al.

Summary: Orally administered semaglutide at doses of 7 and 14 mg improved health-related quality of life compared to dulaglutide 0.75 mg in the PIONEER 10 trial, particularly in the domains of anxiety and dissatisfaction with treatment. These improvements were more pronounced with the higher dose of 14 mg and were sustained over time.

DIABETES THERAPY (2021)

Article Endocrinology & Metabolism

The use of liraglutide 3.0 mg daily in the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first episode psychosis: Results of a pilot randomized, double-blind, placebo-controlled trial

Clare A. Whicher et al.

Summary: The study aimed to investigate the feasibility and acceptability of using liraglutide in managing obesity in individuals with severe mental illness. Results showed significant weight loss in the liraglutide group, supporting the need for a larger randomized controlled trial.

DIABETES OBESITY & METABOLISM (2021)

Article Medicine, General & Internal

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity The STEP 3 Randomized Clinical Trial

Thomas A. Wadden et al.

Summary: This study compared the effects of once-weekly subcutaneous semaglutide with placebo as an adjunct to intensive behavioral therapy and initial low-calorie diet for weight management in adults with overweight or obesity. The results showed that semaglutide led to significantly greater weight loss compared to placebo over 68 weeks, with a higher proportion of participants achieving weight loss goals. More research is needed to evaluate the long-term effectiveness of this treatment.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, doubleblind, double-dummy, placebo-controlled, phase 3 trial

Melanie Davies et al.

Summary: In this study, once-weekly subcutaneous semaglutide 2.4 mg was shown to achieve a significantly greater and clinically meaningful weight reduction compared to placebo in adults with overweight or obesity and type 2 diabetes. Adverse events, particularly gastrointestinal events, were more common with semaglutide compared to placebo.

LANCET (2021)

Article Medicine, General & Internal

Once-Weekly Semaglutide in Adults with Overweight or Obesity

John P. H. Wilding et al.

Summary: The study demonstrates that for individuals with obesity, once-weekly use of 2.4 mg semaglutide in combination with lifestyle intervention can lead to sustained and clinically relevant weight loss, with significant improvements in cardiometabolic risk factors and physical functioning reported by participants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity The STEP 4 Randomized Clinical Trial

Domenica Rubino et al.

Summary: Continuing treatment with semaglutide resulted in greater weight loss maintenance and improvement in other physical indicators compared to switching to placebo over a 48-week period in adults with overweight or obesity. The study also found that gastrointestinal events were more common with continued semaglutide, but discontinuation rates were similar between the two groups.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Psychiatry

Topiramate mitigates weight gain in antipsychotic-treated patients with schizophrenia: meta-analysis of randomised controlled trials

Kah Kheng Goh et al.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE (2019)

Review Pharmacology & Pharmacy

Strategies to counter antipsychotic-associated weight gain in patients with schizophrenia

Wade Marteene et al.

EXPERT OPINION ON DRUG SAFETY (2019)

Article Endocrinology & Metabolism

Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial

Helena W. Rodbard et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Endocrinology & Metabolism

Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial

Richard E. Pratley et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Review Environmental Sciences

An Overview of Factors Associated with Adherence to Lifestyle Modification Programs for Weight Management in Adults

AliceW. Y. Leung et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

Article Public, Environmental & Occupational Health

Attending to physical health in mental health services in Australia: a qualitative study of service users' experiences and expectations

Sarah J. Young et al.

HEALTH & SOCIAL CARE IN THE COMMUNITY (2017)

Article Medicine, General & Internal

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

Steven P. Marso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Endocrinology & Metabolism

Molecular pathophysiology of metabolic effects of antipsychotic medications

Jacob S. Ballon et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

Review Endocrinology & Metabolism

Metabolic and cardiovascular adverse effects associated with antipsychotic drugs

Marc De Hert et al.

NATURE REVIEWS ENDOCRINOLOGY (2012)

Article Clinical Neurology

Extent and management of cardiovascular risk factors in patients with type 2 diabetes and serious mental illness

Julie Kreyenbuhl et al.

JOURNAL OF NERVOUS AND MENTAL DISEASE (2006)

Article Medicine, General & Internal

Disparities in diabetes care - Impact of mental illness

SM Frayne et al.

ARCHIVES OF INTERNAL MEDICINE (2005)

Article Psychiatry

Compliance with antipsychotic treatment

M Oehl et al.

ACTA PSYCHIATRICA SCANDINAVICA (2000)