3.8 Article

Malaria vaccines: the 60-year journey of hope and final success-lessons learned and future prospects

期刊

TROPICAL MEDICINE AND HEALTH
卷 51, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s41182-023-00516-w

关键词

Malaria; Plasmodium falciparum; Vaccine; Development; History; Challenges; Approval; RTS; S; Implementation program; Pre-erythrocytic vaccines; Erythrocytic vaccines; Blood-stage vaccines; Transmission blocking vaccines; Control; Elimination

向作者/读者索取更多资源

This article reviews the history and development stages of malaria vaccines, including the recent approval of the RTS,S/AS01 vaccine by the World Health Organization. It explores other potential vaccine candidates and suggests their further development. Multi-component vaccines may play a crucial role in eradicating malaria.
BackgroundThe world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science. In 2021 the World Health Organization (WHO) approved the first malaria vaccine, RTS,S/AS01 vaccine (Mosquirix (TM)), for widespread use.Main abstract bodyThis review highlights the history of development, and the different approaches and types of malaria vaccines, and the literature to date. It covers the developmental stages of RTS,S/AS01 and recommends steps for its deployment. The review explores other potential vaccine candidates and their status, and suggests options for their further development. It also recommends future roles for vaccines in eradicating malaria. Questions remain on how RTS,S vaccine will work in widespread use and how it can best be utilized to benefit vulnerable communities.ConclusionMalaria vaccines have been in development for almost 60 years. The RTS,S/AS01 vaccine has now been approved, but cannot be a stand-alone solution. Development should continue on promising candidates such as R21, PfSPZ and P. vivax vaccines. Multi-component vaccines may be a useful addition to other malaria control techniques in achieving eradication of malaria.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

3.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据