期刊
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
卷 72, 期 -, 页码 -出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2023.3265117
关键词
Sensors; Electrodes; Impedance; COVID-19; Integrated circuits; Antibodies; Impedance measurement; Biosensor; electronic readout system; impedance measurement; SARS-CoV-2
This article presents a portable impedimetric biosensor for detecting infectious diseases, such as SARS-CoV-2 infections. A bio-ready sensing electrode functionalized with SARS-CoV-2 nucleocapsid antibody was employed to quantitatively convert the concentration of nucleocapsid protein (N-protein) into impedance changes. The proposed impedimetric sensing system can be adopted for the detection of infectious diseases in the future.
This article presents a portable impedimetric biosensor for detecting infectious diseases, such as SARS-CoV-2 infections. A bio-ready sensing electrode functionalized with SARS-CoV-2 nucleocapsid antibody was employed to quantitatively convert the concentration of nucleocapsid protein (N-protein) into impedance changes. In this article, we proposed a readout system with a dynamic input range of 200-O-1-MO magnitude and 0(?)-180(?) phase. The resolution of this device is 1% and 6.5(?) for measuring the magnitude and phase, respectively. Herein, we demonstrate and discuss the proposed system's functionality, sensitivity, and selectivity using the clinical swab samples. As per these results, this readout system is suitable for the detection of N-protein ranging up to 10 000 pg/mL with a resolution of 56 fg/mL. The proposed impedimetric sensing system can be adopted for the detection of infectious diseases in the future. This low-cost (<$80) device using off-the-shelf is a unique candidate for batch production purposes during urgent pandemic situations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据