☆ 4.7 Review

Structure-effect relationship studies of polysaccharides based on receptor-active centres: an alternative view

FOOD & FUNCTION (2023)

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Review Spectroscopy

Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2017-2018

David J. . Harvey

Summary: This review provides a comprehensive update on the application of matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates. It covers various aspects including theory, methods, applications, and medical/industrial uses, highlighting the advancements and achievements in the field.

MASS SPECTROMETRY REVIEWS (2023)

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Article Chemistry, Applied

Recent advances in polysaccharides from the genus Polygonatum: Isolation, structures, bioactivities, and application

Yunfei Hu et al.

Summary: This review summarizes the approaches used for GPPs extraction, purification, and structural characterization, and discusses the diverse biological activities of GPPs to support their potential application value in the functional foods, pharmaceuticals field, and cosmetics areas. New valuable insights for future research regarding GPPs were also proposed in the fields of the natural production of bio-based functional materials, functional foods, and therapeutic agents.

FOOD HYDROCOLLOIDS (2023)

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Article Biochemistry & Molecular Biology

Gas-phase infrared spectroscopy of glycans and glycoconjugates

Kim Greis et al.

Summary: Glycans are complex biomolecules that present analytical challenges. Current workflows based on mass spectrometry often lack direct structural information and the ability to distinguish isomers. Gas-phase infrared spectroscopy has emerged as a promising technique for glycan fingerprinting and can be integrated into mass spectrometry-based workflows.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)

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Article Chemistry, Applied

Revealing the architecture and solution properties of polysaccharide fractions from Macrolepiota albuminosa (Berk.) Pegler

Yu-Xiao Wang et al.

Summary: Macrolepiota albuminosa polysaccharides have complex structures and solution properties affected by factors such as molecular weight, monosaccharide composition, and linkage patterns. Different fractions exhibit structural heterogeneity, influencing their solution properties.

FOOD CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: A review

Xuelin Mo et al.

Summary: Radix Hedysari is a traditional Chinese herbal medicine with a long history of medicinal use. Its polysaccharides are the most important active compounds, which have various biological activities. The chemical structure of polysaccharides is the basis of their biological activity, influenced by factors such as monosaccharide composition and molecular weight. There is limited research on the structure-function relationship of these polysaccharides, but some relationships can be inferred.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Structural characterization, antioxidant activity, and protective effect against hydrogen peroxide-induced oxidative stress of chemically degraded Gracilaria fisheri sulfated galactans

Tawut Rudtanatip et al.

Summary: In this study, sulfated galactans were degraded using trifluoroacetic acid method, and the low molecular weight sulfated galactans (LMSG) showed greater antioxidant activity. The LMSG exhibited higher scavenging activities and enhanced the cellular activities of antioxidant enzymes. Moreover, LMSG activated Nrf-2/ARE signaling and increased expression of antioxidant genes, leading to increased protective effects against oxidative stress.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Sulfated Chinese yam polysaccharide enhances the immunomodulatory activity of RAW 264.7 cells via the TLR4-MAPK/NF-κB signaling pathway

Xuan Liu et al.

Summary: In this study, Chinese researchers isolated Chinese yam polysaccharide (CYP) from yam and then obtained the sulfated derivative (S-CYP). They evaluated the immunomodulatory activity of S-CYP in RAW 264.7 cells and investigated its mechanism of action. The results showed that S-CYP had excellent immunomodulatory activity by increasing the viability of macrophage cells and stimulating the production of immune-related proteins. Signal transduction experiments revealed that S-CYP activated MAPK and NF-κB pathways through TLR4, leading to the increased expression of immune proteins. These findings suggest that both CYP and S-CYP can serve as immunomodulatory agents with potential applications in the food and pharmaceutical industries.

FOOD & FUNCTION (2022)

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Review Chemistry, Applied

Bioactive polysaccharides from red seaweed as potent food supplements: a systematic review of their extraction, purification, and biological activities

Si-Min Qiu et al.

Summary: Most marine macroalgae have bioactive compounds, red seaweeds in particular are rich sources of bioactive polysaccharides with various physiological and biological activities. However, the lack of comprehensive information and human clinical trials on red seaweed polysaccharides limits their industrial-scale utilization in functional foods. This review summarizes recent information on the extraction, purification, biological activities, and molecular principles of red seaweed polysaccharides, providing a basis for further research on their structure, mechanisms, and applications in functional foods.

CARBOHYDRATE POLYMERS (2022)

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Review Chemistry, Multidisciplinary

Mass Spectrometry-Based Techniques to Elucidate the Sugar Code

Marko Grabarics et al.

Summary: Cells encode information in biopolymers, but little is known about the sugar code and biological roles of these molecules. The complexity of carbohydrate structures has made their analysis challenging, but recent advances in mass spectrometry have revolutionized glycan analysis.

CHEMICAL REVIEWS (2022)

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Article Biochemistry & Molecular Biology

Complete 1H and 13C NMR chemical shift assignments of mono-to tetrasaccharides as basis for NMR chemical shift predictions of oligo- and polysaccharides using the computer program CASPER

Axel Furevi et al.

Summary: This article introduces a method for determining the structure of carbohydrates using NMR spectroscopy and computational approaches. The CASPER program can predict H-1 and C-13 NMR chemical shifts based on chemical shift data, and the accuracy of these predictions can be improved by experimental assignment of chemical shifts. The program was used to predict chemical shifts and determine structures of oligosaccharides containing sialic acid and O-antigen polysaccharides from E. coli O174, showing good agreement between experimental and predicted data.

CARBOHYDRATE RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Dectin-1b activation by arabinoxylans induces trained immunity in human monocyte-derived macrophages

Bart G. J. Moerings et al.

Summary: Arabinoxylans of different structures and sources can induce immune responses in different cell types, possibly through the activation of pattern recognition receptors. They can also induce a non-specific memory response in innate immune cells through the activation of specific receptors. Arabinoxylan preparations from rice and wheat can induce immune training and resilience effects in human macrophages, mainly dependent on the Dectin-1b receptor.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Effects of selenylation modification on the antioxidative and immunoregulatory activities of polysaccharides from the pulp of Rose laevigata Michx fruit

Qiping Zhan et al.

Summary: This study investigated the effects of selenylation modification on the structure and functions of PPRLMF-2. The results showed that selenylation increased the antioxidative and immunoregulatory activities of PPRLMF-2, making it a potential source of antioxidants, immune enhancers, and dietary selenium supplements.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Structural features and anticancer mechanisms of pectic polysaccharides: A review

Fangfang Yue et al.

Summary: Based on the structure characteristics and enzymatic process of pectic polysaccharides (PPs), the anticancer mechanism and related structural features were clarified. PPs not only exert direct effects on cancer cells, but also regulate the immune system, gut microbiota, and gut metabolism, jointly contributing to their anticancer activity.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Pharmacology & Pharmacy

Bletilla striata Oligosaccharides Improve Ulcerative Colitis by Regulating Gut Microbiota and Intestinal Metabolites in Dextran Sulfate Sodium-Induced Mice

Tianxiang Zhu et al.

Summary: This study aimed to investigate the mechanism of Bletilla striata oligosaccharides (BO) in the treatment of ulcerative colitis (UC). The results showed that BO effectively inhibited the release of inflammatory cytokines, promoted mucin secretion and tight junction protein expression, and regulated gut microbiota and intestinal metabolites. BO played a role in improving UC by modulating gut microbial composition and intestinal metabolites.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Recent advances in medicinal and edible homologous polysaccharides: Extraction, purification, structure, modification, and biological activities

Hongkun Xue et al.

Summary: This article introduces the homology of medicine and food in traditional Chinese medicine, and discusses the information on the extraction, purification, structure, modification, biological activities, and potential mechanisms of polysaccharides in traditional Chinese medicine.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Medicine, Research & Experimental

Peucedanum praeruptorum Dunn polysaccharides regulate macrophage inflammatory response through TLR2/TLR4-mediated MAPK and NF-KB pathways

Ming Zhao et al.

Summary: The present study investigated the molecular mechanisms of macrophage inflammatory response to polysaccharides from Peucedanum praeruptorum Dunn (PPDs). The study identified that PPDs modulated macrophage activation mainly through TLR2/TLR4-dependent MAPK and NF-KB pathways, affecting cell phagocytic activity and expression and secretion of inflammatory factors and chemokines.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Food Science & Technology

Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): Production, physicochemical and biological properties, and structure-function relationships

Zhichang Qiu et al.

Summary: Garlic polysaccharides and oligosaccharides, as the main functional carbohydrates in garlic, have future research value. This article provides a detailed review of research progress on garlic polysaccharides/oligosaccharides, and identifies knowledge gaps in extraction, composition, structural features, physicochemical properties, and bioactivities. Future research directions are also discussed.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2022)

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Article Biochemistry & Molecular Biology

The mannose receptor ligands and the macrophage glycome

Richard D. Cummings

Summary: The mannose receptor is a glycan-binding protein expressed in macrophages and some types of immune cells, and it plays important roles in various biological processes, potentially related to the macrophage glycome.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Extraction, purification, structural characterization, and gut microbiota relationship of polysaccharides: A review

Yuzhe Huang et al.

Summary: Intestinal dysbiosis is a major cause of metabolic syndromes. Polysaccharide-based microbial therapeutic strategies have potential in the treatment of metabolic syndromes, but the underlying regulatory mechanisms are unclear. Understanding the internal regulatory mechanism of the gut microbiome is essential for precise control and valuable clinical data.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Multiple Fingerprints and Spectrum-Effect Relationship of Polysaccharides from Saposhnikoviae Radix

Mengqi Yu et al.

Summary: PMP-HPLC, FT-IR, and HPSEC fingerprints of polysaccharides from Saposhnikoviae Radix were prepared and analyzed. The results showed high similarity among the fingerprints, and specific markers for quality control were identified. The anti-allergic activity of the polysaccharides was related to monosaccharide composition and molecular weight.

MOLECULES (2022)

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Article Food Science & Technology

Purification, structural characterization, and bioactivities of a polysaccharide from Coreopsis tinctoria

Qian Yu et al.

Summary: Coreopsis tinctoria Nutt. is widely cultivated in western regions of China. A water-soluble polysaccharide (CT70-1) was isolated from C. tinctoria, which showed inhibitory activity against α-amylase, α-glucosidase, and nitric oxide production. These findings provide a foundation for the potential use of CT70-1 in the food and pharmaceutical industries.

FOOD FRONTIERS (2022)

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Review Biochemistry & Molecular Biology

The effect of structure and preparation method on the bioactivity of polysaccharides from plants and fungi

Manli Yang et al.

Summary: Polysaccharides are important components in cell walls of plants and fungi, and they provide structural support and protection for cells. The biological activities of polysaccharides from plants and fungi are influenced by their physicochemical properties and structure, including molecular weight, monosaccharide composition, chain structure, and uronic acid content. The structure of natural polysaccharides can limit their biological activity, but chemical modification and degradation can enhance their pharmacological properties. Processing methods also affect the structure and yield of polysaccharides.

FOOD & FUNCTION (2022)

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Review Materials Science, Multidisciplinary

Recent progress in single-crystal structures of organic polymers

Miaomiao Xue et al.

Summary: Growing single crystals of organic polymers is important but challenging. The field has received substantial attention and witnessed inspiring progress. This review provides a summary of suitable polymer single crystals, with confirmed structures, and presents their preparation, properties, and potential applications.

JOURNAL OF MATERIALS CHEMISTRY C (2022)

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Article Food Science & Technology

Structure-immunomodulatory activity relationships of dietary polysaccharides

Ruoxin Chen et al.

Summary: This review explores the structure-activity relationship of polysaccharides, highlighting the contributions of molecular weight, monosaccharide composition, functional groups, types of glycoside bonds, conformation, and branching degrees to immunostimulatory activity. However, the limited purity and heterogeneity of polysaccharides pose challenges to studying their structure-activity relationships.

CURRENT RESEARCH IN FOOD SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Structural characterization of Poria cocos oligosaccharides and their effects on the hepatic metabolome in high-fat diet-fed mice

Lin Zhu et al.

Summary: In this study, novel Poria cocos oligosaccharides (PCO) were prepared by enzymatic degradation and found to have a polymerization degree of 2-6. PCO showed significant suppression of lipid metabolism disorders in a mouse model with dyslipidemia. Metabolomic analysis indicated that PCO may reverse the altered metabolic pathways related to glycerophospholipids, unsaturated fatty acids, amino acids, choline, bile acids, tryptophan, sphingolipids, and glutathione. These findings highlight the potential use of PCO for treating dyslipidemia.

FOOD & FUNCTION (2022)

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Review Chemistry, Applied

Extraction of polysaccharides from edible mushrooms: Emerging technologies and recent advances

Yoong Kit Leong et al.

Summary: Mushroom-derived polysaccharides, especially beta-glucans, have gained significant interest for their antioxidant, antitumor, immune-modulating properties and other health benefits. A variety of advanced extraction technologies are now available for recovering these bioactive ingredients, each with its own strengths and limitations.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides

Han Xu et al.

Summary: Glycans and glycoconjugates are high molecular weight compounds with important biological activities found in all living organisms. The heterogeneity of naturally occurring glycans and glycoconjugates complicates detailed structure-activity relationship studies. Thus, the synthesis of homogeneous or nearly homogeneous glycans is crucial for the development of carbohydrate-based drugs.

CARBOHYDRATE POLYMERS (2021)

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Review Food Science & Technology

The primary, secondary, and structures of higher levels of pectin polysaccharides

Artur Zdunek et al.

Summary: Pectin, a heteropolysaccharide found in plants, mainly obtained from fruits like citrus and apple, has properties that are influenced by changes during ripening. The properties of pectin depend on the string-like structure of molecules, impacting their interaction and with the environment. This review highlights the importance of understanding the structures of pectin chains at different levels for exploring its functionality.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2021)

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Article Chemistry, Applied

A novel LC-MS/MS method for complete composition analysis of polysaccharides by aldononitrile acetate and multiple reaction monitoring

Ye Li et al.

Summary: A new method combining liquid chromatography-tandem mass spectrometry (LC-MS/MS) and aldononitrile acetate derivatization (AND) has been developed for the comprehensive characterization of monosaccharide composition in plant derived polysaccharides. The optimized method can effectively separate 17 carbohydrates and is more powerful than traditional GLC-based methods for analyzing complex natural polysaccharides.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

A specific and bioactive polysaccharide marker for Cordyceps

Li-Feng Li et al.

Summary: The study identified a specific polysaccharide marker CCP for Cordyceps, which can be used for both qualitative and quantitative analysis of Cordyceps by inducing NO and cytokine production in cells.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Applied

Recent advances in antiviral activities and potential mechanisms of sulfated polysaccharides

Wenjing Lu et al.

Summary: This review highlights the antiviral mechanisms of sulfated polysaccharides, suggesting that they may interfere with various steps in the virus life cycle or enhance host immune response. Additionally, the antiviral activity of sulfated polysaccharides is influenced by factors such as degree of substitution, substitution position, molecular weight, and spatial conformation, providing insights for the development of novel therapeutic agents.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Analytical

Quantitative assessment of C-polysaccharide in capsular polysaccharides of Streptococcus pneumoniae by 31PNMR

Raine Garrido et al.

Summary: This study presents an improved quantitative P-31-NMR methodology for the quantification of C-polysaccharide in capsular polysaccharide preparations, allowing discrimination between phosphocholine residues linked in different positions. The method was successfully applied to samples of vaccine serotypes, showing good quantification performance with a signal/noise ratio of 16:1. Repeatability and intermediate precision evaluation demonstrated the method's stability, while also providing information on the structural identity of phosphate contained in capsular polysaccharides and C-polysaccharide species.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Review Biochemistry & Molecular Biology

Extraction, purification, separation, structure, derivatization and activities of polysaccharide from Chinese date

Junchi Li et al.

Summary: Chinese date is rich in polysaccharides and other active ingredients, which exhibit various activities such as antioxidant, anti-inflammatory, and anti-tumor properties. Research on the extraction, purification, structure, and activity of Chinese date polysaccharides was reviewed, with suggestions for structural reconstruction presented.

PROCESS BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Characterization, prebiotic and immune-enhancing activities of rhamnogalacturonan-I-rich polysaccharide fraction from molokhia leaves

Hye-Bin Lee et al.

Summary: Polysaccharides extracted from molokhia leaves exhibit prebiotic and immune-enhancing activities, showcasing their potential as beneficial additives in the food industry.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Agriculture, Multidisciplinary

Structural characterization of polysaccharide from jujube (Ziziphus jujuba Mill.) fruit

Xiaolong Ji et al.

Summary: The study investigated the special structure of a homogeneous acidic polysaccharide (PZMP4) produced from Ziziphus Jujuba cv. Muzao fruit. The results revealed a netted structure with molecular aggregates of PZMP4, consisting of various components that may indicate distinct bioactivities.

CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE (2021)

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Article Biochemistry & Molecular Biology

Understanding the Effect of Conformational Rigidity on Rheological Behavior and Formation of Polysaccharide-Based Hybrid Hydrogels

Chang-Sheng Wang et al.

Summary: The importance of conformational rigidity on macroscopic rheological properties was demonstrated through the comparison of two model polysaccharides, xanthan gum and hyaluronic acid. Xanthan gum, with its rigid tertiary structure and network formation, exhibits stronger shear thinning and solid-like behavior compared to the relatively flexible tertiary conformation of hyaluronic acid. Additionally, xanthan gum shows better resistance against environmental changes and the ability to form gels with chitosan via electrostatic interactions, which is not possible for hyaluronic acid due to its flexible tertiary conformation.

BIOMACROMOLECULES (2021)

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Review Chemistry, Applied

Triple-helix polysaccharides: Formation mechanisms and analytical methods

Xiaoyu Guo et al.

Summary: This review specifically examines the formation mechanisms, structure-activity relationships, and analytical methods for triple-helix polysaccharides. The insights provided can be valuable for exploring the biological activities of polysaccharides and their applications in the food and pharmaceutical industries.

CARBOHYDRATE POLYMERS (2021)

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Article Agricultural Engineering

Polysaccharides isolated from Lycium barbarum L. by integrated tandem hybrid membrane technology exert antioxidant activities in mitochondria

Jianfei Liu et al.

Summary: Variations in molecular weight of polysaccharides can result in different pharmacological functions. An integrated tandem hybrid membrane technology (ITHMT) was developed to successfully separate polysaccharides extracted from Lycium barbarum L., with preliminary structural analysis conducted.

INDUSTRIAL CROPS AND PRODUCTS (2021)

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Discrimination and characterization of Panax polysaccharides by 2D COS-IR spectroscopy with chemometrics

Yan-Li Lu et al.

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: Systematic review

Zelalai Simayi et al.

Summary: Glycyrrhiza, a widely used Chinese herbal medicine, contains polysaccharides with various biological activities such as antioxidant, anti-tumor, and immune regulation. A systematic review of the isolations, structural characterizations, and biological activities of Glycyrrhiza polysaccharides over the past 15 years was conducted, aiming to provide new insights for further research and development.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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A Multidimensional Mass Spectrometry-Based Workflow for De Novo Structural Elucidation of Oligosaccharides from Polysaccharides

Juan Jose Castillo et al.

Summary: Carbohydrates play crucial roles in biological processes, but characterizing their structures is challenging. A new mass spectrometry-based workflow was developed to elucidate oligosaccharide structures. This approach successfully analyzed oligosaccharides from standards and food products, revealing their detailed structures.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

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Mass spectrometry for structural elucidation and sequencing of carbohydrates

Junqiao Wang et al.

Summary: Carbohydrates are the most abundant organic compounds in nature, and understanding their structure properties through mass spectrometry technology is crucial for their applications, especially in characterizing herbal and food polysaccharides. The development of ionization sources and mass analysers in MS has opened up new possibilities for research in this area.

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Antioxidant, anti-inflammatory and renoprotective effects of acidic-hydrolytic polysaccharides by spent mushroom compost (Lentinula edodes) on LPS-induced kidney injury

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Recent Advances in Chain Conformation and Bioactivities of Triple-Helix Polysaccharides

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Large scale genome skimming from herbarium material for accurate plant identification and phylogenomics

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Consecutive and progressive purification of food-derived natural polysaccharide: Based on material, extraction process and crude polysaccharide

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Glycan structures and their interactions with proteins. A NMR view

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Recent advances in glycoinformatic platforms for glycomics and glycoproteomics

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Extraction methods, chemical characterizations and biological activities of mushroom polysaccharides: A mini-review

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2020s: The Homecoming Decade of High-Throughput Investigation of Polysaccharides

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A nonenzymatic method for cleaving polysaccharides to yield oligosaccharides for structural analysis

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Three-Dimensional Structures of Carbohydrates and Where to Find Them

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Synergistic immunomodulatory effect of complex polysaccharides from seven herbs and their major active fractions

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A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-κB and PI3K/Akt signaling pathways

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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

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Rheological properties and chain conformation of soy hull water-soluble polysaccharide fractions obtained by gradient alcohol precipitation

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Structural characterization and immunostimulatory activity of a novel polysaccharide isolated with subcritical water from Sagittaria sagittifolia L.

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Advancing Solutions to the Carbohydrate Sequencing Challenge

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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The Preparation and Structure Analysis Methods of Natural Polysaccharides of Plants and Fungi: A Review of Recent Development

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Purification, chemical characterization and antioxidant activities of polysaccharides isolated from Mycena dendrobii

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Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review

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Cooperative Order-Disorder Transition of Carboxylated Schizophyllan in Water-Dimethylsulfoxide Mixtures

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Chemical Structure and Composition of Major Glycans Covalently Linked to Therapeutic Monoclonal Antibodies by Middle-Down Nuclear Magnetic Resonance

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Triple-Helix Conformation of a Polysaccharide Determined with Light Scattering, AFM, and Molecular Dynamics Simulation

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Extended chain conformation of β-glucan and its effect on antitumor activity

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Fast, High Resolution, and Wide Modulus Range Nanomechanical Mapping with Bimoda Tapping Mode

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UPLC-MS/MS detection of disaccharides derived from glycosaminoglycans as biomarkers of mucopolysaccharidoses

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Automated Glycan Sequencing from Tandem Mass Spectra of N-Linked Glycopeptides

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Modification of lily polysaccharide by selenylation and the immune-enhancing activity

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Structure and bioactivity of a polysaccharide containing uronic acid from Polyporus umbellatus sclerotia

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Structure, chain conformation, and immunomodulatory activity of the polysaccharide purified from Bacillus Calmette Guerin formulation

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Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus

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Mechanical and structural property analysis of bacterial cellulose composites

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Structure and chain conformation of a neutral intracellular heteropolysaccharide from mycelium of Paecilomyces cicadae

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Structural elucidation of polysaccharide containing 3-O-methyl galactose from fruiting bodies of Pleurotus citrinopileatus

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The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets

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Characterization of a novel galactan produced by Weissella confusa KR780676 from an acidic fermented food

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Review Biochemistry & Molecular Biology

Bioactivities, isolation and purification methods of polysaccharides from natural products: A review

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Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence

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Systems Glycobiology: Integrating Glycogenomics, Glycoproteomics, Glycomics, and Other 'Omics Data Sets to Characterize Cellular Glycosylation Processes

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A molecular dynamics study of the effect of glycosidic linkage type in the hemicellulose backbone on the molecular chain flexibility

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Improved Carbohydrate Structure Generalization Scheme for 1H and 13C NMR Simulations

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Physicochemical characterization of the polysaccharide from Bletilla striata: Effect of drying method

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Structure function relationships of immunostimulatory polysaccharides: A review

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A comparative study of the neutral and acidic polysaccharides from Allium macrostemon Bunge

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Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles

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Structures, Thermal Behaviors, and Luminescent Properties of Anhydrous Lanthanum Iodate Polymorphs

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Enzymatic and acidic degradation effect on intracellular polysaccharide of Flammulina velutipes SF-08

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Anticancer properties of low molecular weight oat beta-glucan - An in vitro study

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Identification and functional analysis of the autofluorescent substance in Limonium bicolor salt glands

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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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Isolation, characterization and antioxidant activity of polysaccharide from Schisandra sphenanthera

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Structural differences and conformational characterization of five bioactive polysaccharides from Lentinus edodes

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MIRAGE: The minimum information required for a glycomics experiment

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NMR structure analysis of uniformly 13C-labeled carbohydrates

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Characterization of Lycium barbarum polysaccharide and its effect on human hepatoma cells

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The Minimum Information Required for a Glycomics Experiment (MIRAGE) Project: Improving the Standards for Reporting Mass-spectrometry-based Glycoanalytic Data

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Structure and antioxidant activity of polysaccharide POJ-U1a extracted by ultrasound from Ophiopogon japonicus

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Polysaccharide from Ganoderma atrum induces tumor necrosis factor-α secretion via phosphoinositide 3-kinase/Akt, mitogen-activated protein kinase and nuclear factor-κB signaling pathways in RAW264.7 cells

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Antitumor activity of mushroom polysaccharides: a review

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Structural Analysis of Glycans by NMR Chemical Shift Prediction

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Structure and chain conformation of water-soluble heteropolysaccharides from Ganoderma lucidum

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Single molecule atomic force microscopy and force spectroscopy of chitosan

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Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides

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Immunoregulatory actions of polysaccharides from Chinese herbal medicine

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Acetylation of wheat straw hemicelluloses in ionic liquid using iodine as a catalyst

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Glycosylation in cellular mechanisms of health and disease

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CELL (2006)

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Polysaccharide isolated from Poria cocos sclerotium induces NF-κB/Rel activation and NOS expression through the activation of p38 kinase in murine macrophages

KY Lee et al.

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The influence of glucan polymer structure and solution conformation on binding to (1→3)-β-D-glucan receptors in a human monocyte-like cell line

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