期刊
CURRENT OPINION IN VIROLOGY
卷 16, 期 -, 页码 106-113出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.01.020
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资金
- National Institute of Allergy and Infectious Diseases [HHSN272201400006C]
- Health and Medical Research Fund of the Hong Kong Government [RRG-10, RRG-14]
- Hong Kong Research Grant Council General Research Fund [RGC-GRF 17118515, 17127714]
- University Grants Committee of the Hong Kong SAR [AoE/M-12/06, T11-705/14-N]
- Shenzhen Peacock Plan High-End Talents Program [KQTD201203]
- Guangdong Top-tier University Development Scheme
- Li Ka Shing Foundation
The occurrence of human infections with avian H7N9 viruses since 2013 demonstrates the continuing pandemic threat posed by the current influenza ecosystem in China. Influenza surveillance and phylogenetic analyses showed that these viruses were generated by multiple interspecies transmissions and reassortments among the viruses resident in domestic ducks and the H9N2 viruses enzootic in chickens. A large population of domestic ducks hosting diverse influenza viruses provided the precondition for these events to occur, while acquiring internal genes from enzootic H9N2 influenza viruses in chickens promoted the spread of these viruses. Human infections effectively act as sentinels, reflecting the intensity of the activity of these viruses in poultry.
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