期刊
CURRENT OPINION IN VIROLOGY
卷 17, 期 -, 页码 95-103出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.02.002
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类别
资金
- NIH [R56 AI117287, U19 AI109946]
- Centers of Influenza Virus Research and Surveillance (CEIRS) [HHSN272201400008C]
- GlaxoSmithKline
- Biomedical Advanced Research and Development Authority (BARDA) [HHSO100201500010C]
Seasonal influenza virus vaccines have to be re-formulated and re-administered on an annual basis due to antigenic drift of the influenza virus surface glycoproteins. In addition, seasonal vaccines show limited efficacy against novel pandemic influenza virus strains, and producing tailored vaccines for these strains in a timely manner is challenging. Several novel broadly protective vaccine candidates targeting the conserved stalk domain of the viral hemagglutinin have been developed. Here we review these novel constructs and discuss several important findings and considerations regarding the protective efficacy of stalk-based vaccines.
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