Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

Article Gastroenterology & Hepatology

Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation

Xuezhen Zeng et al.

Summary: METTL1 plays a role in shaping the immunosuppressive tumor microenvironment after insufficient RFA, influencing tumor recurrence and treatment efficacy.

HEPATOLOGY (2023)

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Article Biotechnology & Applied Microbiology

Targeting N7-methylguanosine tRNA modification blocks hepatocellular carcinoma metastasis after insufficient radiofrequency ablation

Shenghua Zhu et al.

Summary: Radiofrequency heat ablation is an effective treatment for hepatocellular carcinoma, but inadequate ablation can result in high recurrence rates. This study reveals that after ablation, the levels of m7G tRNA modification and its methyltransferase complex components METTL1/WDR4 are upregulated in various systems. Functionally, METTL1-mediated m7G tRNA modification promotes HCC metastasis under sublethal heat exposure. Mechanistically, METTL1 and m7G tRNA modification enhance the translation of SLUG/SNAIL in a codon frequency-dependent manner under sublethal heat stress. These findings provide insights into the role of m7G tRNA modification in heat stress responses and HCC recurrence after ablation, with potential implications for targeted therapies.

MOLECULAR THERAPY (2023)

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Article Gastroenterology & Hepatology

Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy

Haining Liu et al.

Summary: This study reveals that PMN-MDSCs, enriched in advanced ICCs, are significantly correlated with N-7-methylguanosine tRNA methyltransferase METTL1. METTL1 promotes PMN-MDSC accumulation and ICC progression by regulating translational targets like CXCL8 and Cxcl5. Furthermore, co-blockade of METTL1 and its downstream chemokine pathway enhances the efficacy of anti-PD-1 therapy.

GUT (2023)

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Article Oncology

H4-methylation regulators mediated epitranscriptome patterns and tumor microenvironment infiltration characterization in hepatocellular carcinoma

Linyuan Yu et al.

Summary: Epigenetic modifications, specifically histone H4 methylation (H4M), play a crucial role in tumor microenvironment remodeling and immune regulation in hepatocellular carcinoma (HCC). This study identified three distinct H4M modification patterns and found their correlation with TME characteristics and clinical outcome. Evaluation of H4M modification pattern within individual tumors can predict TME infiltration, HRD, intratumor heterogeneity, proliferation activity, stemness index, and prognosis, providing insights for developing effective immunotherapy strategies.

CLINICAL EPIGENETICS (2023)

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Article Oncology

HNRNPC suppresses tumor immune microenvironment by activating Treg cells promoting the progression of prostate cancer

Yifei Cheng et al.

Summary: The study investigates the relationship between N6 methyl adenosine (m6A) methylation and immune microenvironment in prostate cancer (PCa), aiming to identify potential biomarkers for improving immunotherapeutic response. Based on the m6A gene profiles extracted from The Cancer Genome Atlas (TCGA) database, PCa patients were divided into two immune microenvironment subtypes, with IMS2 showing a worse prognosis. HNRNPC was identified as the biomarker for IMS2 and found to inhibit tumor immunity by elevating the activation of regulatory T cells and suppressing effector CD8 T cell. Targeting HNRNPC to activate the immune microenvironment could be a potential therapeutic option for advanced PCa.

CANCER SCIENCE (2023)

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Article Oncology

Comprehensive analysis of N6-methyladenosine regulators with the tumor immune landscape and correlation between the insulin-like growth factor 2 mRNA-binding protein 3 and programmed death ligand 1 in bladder cancer

Jianfeng Cui et al.

Summary: The study reveals that m(6)A clusters and patterns play crucial roles in regulating tumor immunity in bladder cancer, which may be utilized for developing comprehensive treatment strategies.

CANCER CELL INTERNATIONAL (2022)

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Article Gastroenterology & Hepatology

Off-the-Shelf Prostate Stem Cell Antigen-Directed Chimeric Antigen Receptor Natural Killer Cell Therapy to Treat Pancreatic Cancer

Kun-Yu Teng et al.

Summary: This study demonstrates the effectiveness of PSCA CAR_s15 NK cells in suppressing pancreatic cancer both in vitro and in vivo, without causing systematic toxicity. These findings provide a strong rationale for further clinical development.

GASTROENTEROLOGY (2022)

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Article Chemistry, Multidisciplinary

Site-Specific Synthesis of N4-Acetylcytidine in RNA Reveals Physiological Duplex Stabilization

David Bartee et al.

Summary: This study reports the synthesis and biophysical characterization of ac4C in its endogenous eukaryotic sequence context, establishing a chemical foundation for understanding the function of a universally conserved nucleobase in biology and disease.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Medicine, Research & Experimental

5-aza-2′-deoxycytidine potentiates anti-tumor immunity in colorectal peritoneal metastasis by modulating ABC A9-mediated cholesterol accumulation in macrophages

Rongchen Shi et al.

Summary: This study revealed for the first time that 5Aza suppresses CRC-PC by regulating macrophage-dependent T cell activation in the premetastatic microenvironment, and uncovered a novel DNA methylation-independent mechanism of 5Aza in regulating ABC A9-associated cholesterol metabolism and macrophage activation.

THERANOSTICS (2022)

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Article Immunology

Histone Acetylation Regulator-Mediated Acetylation Patterns Define Tumor Malignant Pathways and Tumor Microenvironment in Hepatocellular Carcinoma

Yuyan Xu et al.

Summary: This study provides the first comprehensive analysis of 36 histone acetylation regulators in hepatocellular carcinoma (HCC). Histone acetylation patterns were found to be closely associated with tumor malignant pathways and the tumor microenvironment (TME). The therapeutic value of the HAscore in targeted therapy and immunotherapy was also analyzed.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell-Mediated Antitumor Activity

Hao Zheng et al.

Summary: In this study, the researchers investigated the role of the m6A-METTL14-Siah2-PD-L1 axis in immunotherapy. They found that METTL14 induced Siah2 expression and promoted its degradation through m6A modification. Siah2 was also found to interact with PD-L1 and regulate its levels. Knockdown of Siah2 inhibited T cell expansion and cytotoxicity, and tumors with low Siah2 levels were more sensitive to anti-PD1 immunotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Genetics & Heredity

RNA-Binding Protein IGF2BP1 Associated With Prognosis and Immunotherapy Response in Lung Adenocarcinoma

JinFeng Liu et al.

Summary: This study systematically explored the role of m(6)A methylation regulators in LUAD and found that IGF2BP1 is an independent predictor of LUAD and is associated with immunotherapy response.

FRONTIERS IN GENETICS (2022)

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Article Oncology

Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells

Xiaowu Bai et al.

Summary: YTHDF1 is overexpressed in gastric cancer and promotes cancer growth by inducing cell proliferation and suppressing dendritic cell-mediated anti-tumor immune response. YTHDF1 is a promising therapeutic target for gastric cancer treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Cell Biology

Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients

Lin-jian Wang et al.

Summary: This study reveals the interplay between DNA methylation and RNA post-transcriptional modifications, and their involvement in the development and progression of diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression

Jie Chen et al.

Summary: The study revealed that tRNA m(7)G methyltransferase METTL1 promotes the development and malignancy of head and neck squamous cell carcinoma (HNSCC) by regulating global mRNA translation, including the PI3K/AKT/mTOR signaling pathway, and alters the immune landscape.

CANCER COMMUNICATIONS (2022)

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Article Genetics & Heredity

THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder

Martin Broly et al.

Summary: Covalent tRNA modifications have diverse roles in tRNA stability, folding, translation rate and fidelity, and various cellular processes. Mutations in the THUMPDI gene, involved in tRNA N4-acetylcytidine modification, have been linked to intellectual disability. This study presents individuals with rare loss-of-function variants in THUMPDI, showing common features of developmental delay, intellectual deficiency, behavioral abnormalities, facial dysmorphism, and ophthalmological abnormalities. Functional analysis demonstrates that THUMPDI variants result in a loss of tRNA modification, leading to syndromic intellectual disability.

AMERICAN JOURNAL OF HUMAN GENETICS (2022)

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Article Oncology

Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer

Dragana Kopanja et al.

Summary: This study provides new insights into the critical role of the interaction between FoxM1 and Rb in the plasticity and metastasis of breast cancer cells.

CANCER RESEARCH (2022)

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Article Oncology

JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA

Zegui Ni et al.

Summary: This study reveals that activated JNK signaling is associated with increased expression of METTL3 in bladder cancer. JNK signaling regulates METTL3 expression and global RNA m(6)A levels. Additionally, m(6)A modification is enriched in the 3'-UTR of PD-L1 mRNA, and it is recognized by the m(6)A reader protein IGF2BP1 to mediate the stability and expression levels of PD-L1.

CANCER RESEARCH (2022)

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Article Biochemistry & Molecular Biology

METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer

Weijun Wan et al.

Summary: The study found that METTL3 can post-transcriptionally upregulate PD-L1 expression in an m(6)A-IGF2BP3-dependent manner to promote stabilization of PD-L1 mRNA. This may have important implications for new and efficient therapeutic strategies in tumor immunotherapy.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKK epsilon/TBK1/IRF3 pathway in head and neck squamous cell carcinoma

Shufang Jin et al.

Summary: This study demonstrates that m6A status is downregulated and two demethylases are upregulated in HNSCC. Silencing the m6A demethylase ALKBH5 suppresses tumor progression. ALKBH5 downregulates the m6A modification of DDX58 mRNA, while HNRNPC binds to the m6A sites of DDX58 mRNA to promote its maturation.

MOLECULAR CANCER (2022)

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Article Biochemistry & Molecular Biology

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Jia Xiong et al.

Summary: The lactylation-driven METTL3-mediated RNA m(6)A modification plays an important role in promoting the immunosuppressive capacity of tumor-infiltrating myeloid cells (TIMs).

MOLECULAR CELL (2022)

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Article Multidisciplinary Sciences

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

Ting Zhang et al.

Summary: ADAR1 is a determinant of resistance to ICB therapy by repressing immunogenic dsRNA and Z-RNA. CBL0137 is a small molecule that activates ZBP1, reverses ICB unresponsiveness, and induced necroptosis.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution

Marie-Line Bortolin-Cavaille et al.

Summary: This study reveals the essential role of SNORD13 in the acetylation of a specific cytidine in human and zebrafish 18S rRNA. However, this acetylation does not have a significant impact on human cell growth, ribosome biogenesis, translation, or development. The study also identifies several novel SNORD13 genes and discovers an atypical SNORD13-like RNA in Drosophila melanogaster.

NUCLEIC ACIDS RESEARCH (2022)

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Article Biochemistry & Molecular Biology

N-7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/beta-catenin pathway in nasopharyngeal carcinoma

Binbin Chen et al.

Summary: This study reveals that the N-7-methylguanosine tRNA modification enzyme METTL1 and its partner WDR4 are significantly increased in nasopharyngeal carcinoma (NPC) and are associated with poor prognosis. METTL1/WDR4 promotes NPC growth and metastasis through the WNT/β-catenin signaling pathway, as well as inducing epithelial-mesenchymal transition and chemoresistance.

ONCOGENE (2022)

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Article Cell Biology

A novel mechanism for A-to-I RNA-edited AZIN1 in promoting tumor angiogenesis in colorectal cancer

Yan Wei et al.

Summary: This study investigates the role of RNA-edited AZIN1 in tumor angiogenesis. The findings demonstrate that RNA-edited AZIN1 promotes tumor angiogenesis through upregulation of IL-8. Furthermore, delaying c-Myc degradation via the OAZ2-mediated ubiquitin-independent proteasome pathway contributes to increased mRNA levels and secretion of the angiogenic factor IL-8.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

BRD4 promotes resection and homology-directed repair of DNA double-strand breaks

John K. Barrows et al.

Summary: BRD4 is a multifunctional regulator of chromatin binding that plays a direct role in DNA double-strand break repair, promoting DNA processing through interactions with the SWI/SNF chromatin remodeling complex and resection machinery.

NATURE COMMUNICATIONS (2022)

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Review Cell Biology

Metabolic reprogramming and epigenetic modifications on the path to cancer

Linchong Sun et al.

Summary: Metabolic rewiring and epigenetic remodeling, which are closely linked in cancer development, play important roles in tumor progression and immune escape. Metabolites can affect the function of chromatin-modifying enzymes, influencing processes such as tumor progression and immunosurveillance.

PROTEIN & CELL (2022)

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Article Immunology

A Novel m1A-Score Model Correlated With the Immune Microenvironment Predicts Prognosis in Hepatocellular Carcinoma

Mingxing Zhao et al.

Summary: This study comprehensively analyzed the role of RNA methylation in hepatocellular carcinoma (HCC) using TCGA and GEO databases. The study found that m1A modification patterns were associated with the prognosis, TNM staging, and tumor microenvironment characteristics of HCC. An m1A-score model based on prognosis-related m1A regulators was able to predict the prognosis of HCC patients.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Identification and Verification of m7G Modification Patterns and Characterization of Tumor Microenvironment Infiltration via Multi-Omics Analysis in Clear Cell Renal Cell Carcinoma

Kai Dong et al.

Summary: The study demonstrated the importance of N7-methylguanosine (m(7)G) modification in clear cell renal cell carcinoma (ccRCC). Three distinct m(7)G modification patterns were identified and characterized, and a scoring tool called m7Sig was developed to predict patient prognosis. Understanding m(7)G modification landscape can help improve the characterization and clinical decision making in ccRCC.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas

Cheng Wei et al.

Summary: Comprehensive bioinformatics analysis showed that ALKBH5 is upregulated in multiple solid tumors and promotes the development and progression of cancer through regulation of tumor immunity, as well as cell proliferation, migration, and infiltration.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma

Zhipeng Xu et al.

Summary: This study reveals the potential roles of m5C modification in the biochemical recurrence and tumor microenvironment diversity of prostate adenocarcinoma, providing new insights for future research on prostate cancer.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer

Zijie Gao et al.

Summary: This study reveals the correlation of METTL1 with tumor immune infiltration and stemness in pan-cancer, highlighting the significance of METTL1 in cancer progression and guiding more effective and generalized therapy strategies.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma

Xinya Tong et al.

Summary: The study revealed that NSUN2 is upregulated in NPC and enhances proliferation, migration, and invasion of NPC cells in vitro. Differential expression genes are mainly related to activation and proliferation of multiple immune cells.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Upregulation of MTA1 in Colon Cancer Drives A CD8(+) T Cell-Rich But Classical Macrophage-Lacking Immunosuppressive Tumor Microenvironment

Yantong Zhou et al.

Summary: Upregulation of MTA1 in colorectal cancer drives an immunosuppressive tumor microenvironment by decreasing tumor-associated macrophages and inducing their phenotypic change, which weakens the cytotoxic effect of CD8(+) T cells.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

METTL3 Is Associated With the Malignancy of Esophageal Squamous Cell Carcinoma and Serves as a Potential Immunotherapy Biomarker

Yubin Zhou et al.

Summary: The study found that METTL3 is highly expressed in esophageal squamous cell carcinoma (ESCC) and is associated with poor prognosis. Functional analysis showed that METTL3 is involved in chromosomal homologous recombination and DNA mismatch repair processes, which may be potential mechanisms for tumor development and progression. By identifying immune genes associated with METTL3 and constructing a prognostic prediction model and nomogram, the prognosis of ESCC patients can be accurately evaluated.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy

Ronglin Wang et al.

Summary: This study found that m(5)C regulators play a crucial role in the development of pancreatic adenocarcinoma (PAAD) by modulating the immune microenvironment. A quantitative indicator, the m(5)C score, was developed to predict the immunotherapy response and prognosis of PAAD patients, assisting in selecting tailored immunotherapy strategies.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Characterization of 7-Methylguanosine Identified Biochemical Recurrence and Tumor Immune Microenvironment in Prostate Cancer

Sheng Xin et al.

Summary: This study discovered that m7Gscore can serve as an independent marker for predicting BCR-free survival in prostate cancer patients and is correlated with the tumor immune microenvironment and somatic mutation. Based on the TIME characteristics of m7G-related patterns, prostate cancer can be classified into immune-desert, immune-inflamed, and immune-excluded phenotypes.

FRONTIERS IN ONCOLOGY (2022)

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Article Cell Biology

Molecular Characterization Clinical and Immunotherapeutic Characteristics of m5C Regulator NOP2 Across 33 Cancer Types

Taisheng Liu et al.

Summary: This study comprehensively explored the clinical and immunotherapeutic values of NOP2 in cancers. The results showed that NOP2 was upregulated in most cancers and was closely associated with poor prognosis and immunotherapy inactivation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

5-methylcytosine RNA methylation regulators affect prognosis and tumor microenvironment in lung adenocarcinoma

Taisheng Liu et al.

Summary: This study revealed the significant role of m5C RNA regulators in the regulation of the tumor microenvironment in lung adenocarcinoma (LUAD). The constructed m5C signature (m5Csig) can predict the prognosis of patients with LUAD and provide novel strategies for tumor immunotherapy.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization

Yihao Wu et al.

Summary: This study identifies key AAA-related m1A RNA methylation regulators and their association with immune infiltration in AAA. It reveals that the m1A reader, YTHDF3, may participate in modulating macrophage polarization, promoting aortic inflammation and influencing AAA progression by regulating the expression of its target genes.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Cell Biology

Identification of m7G-associated lncRNA prognostic signature for predicting the immune status in cutaneous melanoma

Jielin Rong et al.

Aging-US (2022)

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Article Multidisciplinary Sciences

ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression

Ni Li et al.

Summary: Loss of ARID1A promotes prostate cancer progression and immunosuppression by promoting the infiltration of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). Inflammatory cues activate IKK beta to phosphorylate ARID1A and degrade it, leading to CXCR2 ligand-mediated PMN-MDSC chemotaxis. Neutralization of PMN-MDSCs restricts the progression of ARID1A-deficient tumors.

NATURE COMMUNICATIONS (2022)

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Article Gastroenterology & Hepatology

METTL3 Inhibits Antitumor Immunity by Targeting m6A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer

Huarong Chen et al.

Summary: This study identifies METTL3 as a potential therapeutic target for CRC immunotherapy. Silencing or inhibiting METTL3 reduces MDSC accumulation, sustains activation and proliferation of CD4(+) and CD8(+) T cells, and ultimately suppresses CRC development. Inhibition of METTL3 plus anti-PD1 treatment shows promising antitumor efficacy against CRC.

GASTROENTEROLOGY (2022)

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Article Immunology

Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p

Sri Murugan Poongkavithai Vadevoo et al.

Summary: This study demonstrates the reprogramming of M2-type tumor-associated macrophages into an M1-like phenotype using epigenetic therapy, specifically the combination of 5-aza-2'-deoxycytidine and trichostatin A. This combination treatment decreases M2 macrophage cytokines and increases M1 macrophage cytokines, sensitizing tumor cells to paclitaxel and inhibiting tumor growth. miR-7083-5p is identified as a key player in this reprogramming process.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer

Stephanie Gomez et al.

Summary: This study demonstrates that decreasing ADAR1 editing enhances the immune response induced by DNMTi in ovarian cancer cells, leading to inhibition of tumor growth and prolonged survival. The findings suggest that inducing transposable element transcription and inhibiting RNA editing can reverse immune evasion in ovarian cancer, providing a novel therapeutic strategy for this disease.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Multidisciplinary Sciences

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

Sylvain Delaunay et al.

Summary: The study reveals that the NSUN3-dependent RNA modifications of mitochondrial mRNA can impact metabolic plasticity, thus affecting the metastatic potential of cancer cells, providing new therapeutic targets for combating cancer metastasis.

NATURE (2022)

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Article Cell Biology

METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis

Xueju Wei et al.

Summary: Wei et al. find that cytoplasmic METTL3 promotes tumour progression by facilitating the translation of epigenetic factor mRNAs without m(6)A modification. This study suggests an m(6)A-independent mechanism for METTL3 in cancer development, highlighting its significance in oncogenesis.

NATURE CELL BIOLOGY (2022)

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Article Genetics & Heredity

Identification and Validation of an m7G-Related lncRNAs Signature for Prognostic Prediction and Immune Function Analysis in Endometrial Cancer

Jiani Sun et al.

Summary: This study investigates the role of N7-methylguanosine-related lncRNAs (MRL) in endometrial cancer and develops a reliable prognostic model. It also identifies differentially expressed genes related to treatment and provides new insights into the underlying molecular mechanism of endometrial cancer.

GENES (2022)

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Article Immunology

An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling

Hao Yang et al.

Summary: Through the analysis of ADM and PDAC tissues, we found that the m7G score is associated with tumor invasiveness, immune cell infiltration, ICI treatment response, and overall patients' survival. The identified core genes, FN1 and ITGB1, play a crucial role in immune cell infiltration and genomic instability.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Genetics & Heredity

Prognostic Signature and Tumor Immune Landscape of N7-Methylguanosine-Related lncRNAs in Hepatocellular Carcinoma

Wei Wei et al.

Summary: This study identified a m7G-related lncRNA risk model that can predict prognosis, immunotherapy response, and drug sensitivity in LIHC patients, providing potential clinical implications.

FRONTIERS IN GENETICS (2022)

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Article Genetics & Heredity

The m7G-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Tumour Immune Infiltration in Colon Cancer

Li Liu et al.

Summary: m7G-related lncRNA is closely related to colon cancer. The risk model based on the 21 signature lncRNAs can effectively evaluate the prognosis of colon cancer patients, which has a positive impact on the future diagnosis and therapy of colon cancer.

FRONTIERS IN GENETICS (2022)

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Article Oncology

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer

Guangyu Sun et al.

Summary: NSUN2 is highly expressed in prostate cancer, promoting the progression of the disease and closely associated with immune cell infiltration and chemotherapy drug sensitivity.

FRONTIERS IN ONCOLOGY (2022)

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Article Immunology

Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells

B. Rhodes Ford et al.

Summary: The response rates to immunotherapy in solid tumors remain low due to the prevalence of terminally exhausted T cells. This study used CUT&RUN method to analyze the histone modification landscape of tumor-infiltrating CD8(+) T cells and found unexpected chromatin features in terminally exhausted T cells that limit their transcriptional potential. The study also linked increased histone bivalency to hypoxia exposure and showed that hypoxia-insensitive histone demethylase Kdm6b can increase cell function and promote antitumor immunity.

SCIENCE IMMUNOLOGY (2022)

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Article Cell Biology

A novel prognostic 7-methylguanosine signature reflects immune microenvironment and alternative splicing in glioma based on multi-omics analysis

Zihan Wang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Pathology

Construction of a 5-methylcytosine-Related Molecular Signature to Inform the Prognosis and Immunotherapy of Lung Squamous Cell Carcinoma

Rong He et al.

Summary: This study investigated the relationship between methylation levels, prognosis, and immunotherapy in patients with lung squamous cell carcinoma (LUSC). The results showed that patients with higher methylation scores had worse prognoses, while those with lower methylation scores responded better to immunotherapy. Therefore, methylation scores may serve as potential biomarkers for predicting the prognosis and immunotherapy response of LUSC patients.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

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Article Oncology

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR

Xiaolong Wang et al.

Summary: Our study revealed the downregulation of circRNA-CREIT in doxorubicin resistant TNBC cells and its association with poor prognosis. We identified the RNA binding protein DHX9 as responsible for the reduction in circRNA-CREIT by interacting with the flanking inverted repeat Alu (IRAlu) sequences and inhibiting back-splicing. Mechanistically, circRNA-CREIT acted as a scaffold to facilitate the interaction between PKR and the E3 ligase HACE1, leading to proteasomal degradation of PKR protein via K48-linked polyubiquitylation and attenuation of the assembly of stress granules (SGs) to activate the RACK1/MTK1 apoptosis signaling pathway. Moreover, circRNA-CREIT could be packaged into exosomes and disseminate doxorubicin sensitivity among TNBC cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs

Han Liao et al.

Summary: NOP2/NSUN1 catalyzes the deposition of m(5)C at position 4447 on the 28S rRNA, and regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs. Additionally, NOP2/NSUN1 facilitates the recruitment and stable assembly of U3 and U8 snoRNAs into snoRNP complexes.

NUCLEIC ACIDS RESEARCH (2022)

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Article Chemistry, Multidisciplinary

FOXM1 Inhibition Enhances the Therapeutic Outcome of Lung Cancer Immunotherapy by Modulating PD-L1 Expression and Cell Proliferation

Hamadi Madhi et al.

Summary: The focus of this study is FOXM1, which is identified as a potential therapeutic target for cancer immunotherapy and associated with the modulation of PD-L1 expression. The study found that selective knockdown of FOXM1 or treatment with TST significantly reduces PD-L1 expression in NSCLC cells and inhibits proliferation. Animal studies showed that TST treatment downregulates PD-L1 expression in NSCLC tumors and reduces tumor size without side effects. Combined treatment with TST and anti-4-1BB antibody induces synergistic therapeutic outcomes against immune resistant lung tumors and increases the number of CD3(+) T cells in tumor tissues.

ADVANCED SCIENCE (2022)

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Article Oncology

Histone lysine methylation patterns in prostate cancer microenvironment infiltration: Integrated bioinformatic analysis and histological validation

Yongjun Quan et al.

Summary: By comprehensively evaluating HLM regulators in the PCa microenvironment, this study reveals the significant role of HLM patterns in the complexity and heterogeneity of prostate cancer. Understanding the effects of HLM regulators in PCa may improve prognosis, aggressiveness assessments, and immunotherapy strategies.

FRONTIERS IN ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

EZH2 as a Prognostic Factor and Its Immune Implication with Molecular Characterization in Prostate Cancer: An Integrated Multi-Omics in Silico Analysis

Tian-Qi Du et al.

Summary: This study found that EZH2 is highly expressed in prostate cancer patients, associated with a poor prognosis, and may serve as an independent prognostic factor. EZH2 expression is associated with DNA methylation modifications, tumor microenvironment, immune-related genes, tumor mutation burden, tumor neoantigen burden, and mismatch repair genes. Our study also suggests that patients with lower EZH2 expression may benefit more from immunotherapy.

BIOMOLECULES (2022)

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Article Oncology

Adenosine-Deaminase-Acting-on-RNA-1 Facilitates T-cell Migration toward Human Melanoma Cells

Naama Margolis et al.

Summary: The interaction between melanoma cells and T cells can enhance the chemotaxis of new T cells. ADAR1-p150 expression is correlated with immune infiltration and can be induced by immunotherapy. ADAR1 regulates T cell migration through the secretion of chemokines.

CANCER IMMUNOLOGY RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

Chen Xue et al.

Summary: Cancer is a major disease that poses a threat to human life and health worldwide. This review explores the role of RNA modifications in cancer progression and provides a detailed summary of the deposition and functions of common RNA modifications in coding and noncoding RNAs. It also discusses the expression, function, and underlying molecular mechanism of these modifications in cancer, as well as the potential of small-molecule inhibitors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Immunology

Natural killer cells in antiviral immunity

Niklas K. Bjorkstrom et al.

Summary: This review explores the role of natural killer cells in acute and chronic viral infections, particularly focusing on insights from patients with primary immunodeficiencies. It also discusses the involvement of natural killer cells in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The review highlights the importance of NK cells in innate immune responses to viral infections and provides recent insights into their role in human studies.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Oncology

Pseudouridine as a novel biomarker in prostate cancer

Jennifer A. Stockert et al.

Summary: Epitranscriptomic analysis has revealed the functional roles of pseudouridine in cancer cells, showing its importance in RNA structure, tRNA decoding activity, translation accuracy, and mRNA regulation. Elevated levels of pseudouridine may be associated with the development and progression of human prostate cancer, making it a potential novel biomarker in advanced disease.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2021)

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Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Medicine, Research & Experimental

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Sreya Bagchi et al.

Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

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Article Oncology

ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment

Feng Dong et al.

Summary: This study reveals that hypoxia-induced upregulation of m(6)A demethylase ALKBH5 leads to the formation of NEAT1-mediated paraspeckles, resulting in increased CXCL8/IL8 expression and enhanced TAM recruitment and tumor progression in GBM. The findings provide evidence for the link between hypoxia-induced epitranscriptomic changes and the formation of an immunosuppressive microenvironment.

CANCER RESEARCH (2021)

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Article Dermatology

ARID2 Deficiency Correlates with the Response to Immune Blockade in Melanoma

Takeshi Fukumoto et al.

Summary: The study demonstrates that ARID2 knockout enhances melanoma sensitivity to immune checkpoint inhibitors by increasing infiltration of cytotoxic CD8(+) T cells and upregulating expression of T-cell-attracting chemokines. These findings suggest that ARID2 acts as an immunomodulator and a potential biomarker for predicting the effectiveness of immune checkpoint inhibitors in melanoma patients.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Multidisciplinary Sciences

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Botai Li et al.

Summary: It was found that circNDUFB2 is downregulated in NSCLC tissues and inhibits the growth and metastasis of NSCLC cells by enhancing the interaction between TRIM25 and IGF2BPs. circNDUFB2 also activates anti-tumor immune responses by binding to RIG-I.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

The Impact of m1A Methylation Modification Patterns on Tumor Immune Microenvironment and Prognosis in Oral Squamous Cell Carcinoma

Li Gao et al.

Summary: This study investigated the relationship between m1A modification patterns and the tumor immune microenvironment in oral squamous cell carcinoma patients. It found that patients in the high m1A score group had a poorer prognosis, lower immune infiltration and expression levels of immune checkpoint molecules.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular carcinoma

Shen Shen et al.

Summary: This study identified three different m6A modification subtypes in hepatocellular carcinoma (HCC) patients, which were associated with different immune cell infiltration phenotypes in the tumor immune microenvironment (TIME). Low expression of METTL3 was correlated with increased infiltration of dendritic cells (DCs) in the TIME, and patients with low m6A scores had better overall survival and 5-year survival rates.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling

Xinya Gao et al.

Summary: The activation of EGFR signalling in GBM is driven by a newly discovered secretory E-cadherin protein variant called C-E-Cad encoded by circular RNA. This mechanism promotes tumorigenicity in glioma stem cells and provides a promising approach for treating EGFR-driven GBM by enhancing the efficacy of anti-EGFR strategies.

NATURE CELL BIOLOGY (2021)

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Article Multidisciplinary Sciences

METTL3-dependent m6A modification programs T follicular helper cell differentiation

Yingpeng Yao et al.

Summary: This study demonstrates the importance of RNA methylation in T-FH effector differentiation and subsequent antibody formation by stabilizing Tcf7 transcripts.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

Huilong Yin et al.

Summary: The study reveals that deletion of Mettl3 in myeloid cells promotes tumor growth and metastasis, as well as affecting the efficacy of PD-1 checkpoint blockade therapy.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

N-1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Yanying Wang et al.

Summary: The study reveals elevated m(1)A methylation levels in hepatocellular carcinoma (HCC) patient tumour tissues and liver cancer stem cells, mediated by the TRMT6/TRMT61A complex. The inhibition of m(1)A methylation can decrease tumourigenesis.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Rajendra Karki et al.

Summary: The study uncovers the role of ADAR1 in suppressing ZBP1-mediated PANoptosis and promoting tumorigenesis. Additionally, the use of IFN-gamma and NEI KPT-330 regresses melanoma in a ZBP1-dependent manner, providing important insights for cancer therapeutic strategies.

CELL REPORTS (2021)

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Article Oncology

An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma

Rui Ma et al.

Summary: The study demonstrated that the combination therapy of an oncolytic virus expressing the IL15/IL15Rα complex and off-the-shelf EGFR-CAR NK cells elicited strong antitumor responses in glioblastoma. This therapy significantly inhibited tumor growth and improved survival rates, offering a promising strategy for the clinical management of this devastating disease.

CANCER RESEARCH (2021)

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Article Cell Biology

Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance

Yi Liu et al.

Summary: Research has identified the m(6)A demethylase FTO as a key regulator in tumors, impacting immune surveillance through glycolytic metabolism regulation. Knockdown of FTO impairs tumor cell glycolytic activity, restores CD8(+) T cell function, and inhibits tumor growth. Additionally, the development of the small-molecule compound Dac51 can block FTO-mediated immune evasion and synergize with checkpoint blockade for improved tumor control.

CELL METABOLISM (2021)

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Article Immunology

A Pan-Cancer Analysis of SMARCA4 Alterations in Human Cancers

Ling Peng et al.

Summary: This study provides insights into the potential oncogenic roles of SMARCA4 in different tumors, showing high expression levels in most cancer types and correlation with poor overall survival in several cancers. Enhanced phosphorylation levels, tumor immunity correlation, and associations with DNA methylation, TMB, MSI, and MMR in cancers were also observed.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Prognostic Risk Model and Tumor Immune Environment Modulation of m5C-Related LncRNAs in Pancreatic Ductal Adenocarcinoma

Hao Yuan et al.

Summary: Through analysis of clinical information and genetic transcriptome data of PDAC patients, a m5C-related lncRNA prognostic risk model was established and its relationship with PDAC immune microenvironment was studied. The risk model showed predictive ability and could potentially serve as a therapeutic target for PDAC patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer

Jinhui Liu et al.

Summary: Recent research has focused on the relationship between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis. The study revealed three different m1A modification patterns in ovarian cancer patients, corresponding to three tumor immune phenotypes, and showed that individual tumor m1A modification patterns can predict patient survival, stage, and grade. High m1Ascore in patients was associated with better survival and lower mutational load, as well as therapeutic benefits in chemotherapy and immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer

Taisheng Liu et al.

Summary: This study explored the potential roles of 5mC regulators in the tumor microenvironment by analyzing DNA methylation patterns in lung adenocarcinoma samples. Three distinct 5mC modification patterns and gene clusters were identified, showing correlations with TME immune cell infiltration patterns and clinical prognoses. The 5mCscore was developed to evaluate tumor mutation burden, immune check-point inhibitor response, and prognosis characteristics, indicating its potential as a novel strategy to treat lung cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer

Daryl Jin Tai Tay et al.

Summary: The study identified chemically modified antisense oligonucleotides (ASOs) targeting AZIN1 that effectively inhibited cancer cell viability in vitro and tumor growth in xenograft models, demonstrating the potential of AZIN1-targeting ASOs for a wide range of tumor types.

MOLECULAR THERAPY (2021)

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Article Multidisciplinary Sciences

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova et al.

Summary: The study identified a highly potent and selective catalytic inhibitor of METTL3, STM2457, which shows potential therapeutic value in treating AML. Treatment with this inhibitor leads to reduced AML growth, increased differentiation and apoptosis, and decreased m(6)A levels on leukemogenic mRNAs. In vivo pharmacological inhibition of METTL3 results in impaired engraftment and prolonged survival in mouse models of AML.

NATURE (2021)

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Article Cell Biology

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

Pingyu Liu et al.

Summary: Research shows that METTL3 and METTL14 promote the senescence-associated secretory phenotype in an m(6)A-independent manner. METTL14 is redistributed to enhancers, while METTL3 is localized to pre-existing NF-kappa B sites in the promoters of SASP genes during senescence. Both are essential for SASP, but it is not regulated by m(6)A mRNA modification.

NATURE CELL BIOLOGY (2021)

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Review Multidisciplinary Sciences

Epigenetic mechanisms in breast cancer therapy and resistance

Liliana Garcia-Martinez et al.

Summary: The majority of breast cancers express the estrogen receptor and endocrine therapy has been the mainstay for hormone-responsive breast cancer treatment. Recent studies have shown the importance of the epigenome in determining hormone therapy response and how targeting epigenetic factors can help overcome clinical resistance. Understanding epigenetic mechanisms regulating ER+ breast cancer and endocrine therapy resistance is crucial for improving targeted therapies for this type of cancer.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation

Jiyu Tong et al.

Summary: Research has identified the important role of METTL3-mediated m(6)A modification in host immune responses, regulating macrophage activation through the TLR signaling pathway. This may serve as a potential target for cancer immunotherapy.

SCIENCE ADVANCES (2021)

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Article Oncology

Prognostic and Immunological Role of mRNA ac4C Regulator NAT10 in Pan-Cancer: New Territory for Cancer Research?

Chuanxi Yang et al.

Summary: NAT10 is a critical gene that regulates N4-acetylcytidine formation in RNA. High NAT10 expression is correlated with poor prognosis in various cancers and significantly associated with tumor immune infiltration, indicating its potential as a target for cancer therapy.

FRONTIERS IN ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors

Simona Selberg et al.

Summary: Two new ALKBH5 inhibitors were found to significantly suppress the proliferation of leukemia cell lines, with IC50 values ranging from 1.38 to 16.5 μM. However, the effect on another leukemia cell line and glioblastoma cell line was minimal. This demonstrates the potential of ALKBH5 inhibition as a selective antiproliferative strategy for certain cancer cell types.

ACS OMEGA (2021)

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Article Oncology

M(6)A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma

Xinyao Qiu et al.

Summary: This study identifies PD-L1 mRNA as a target of ALKBH5 and reveals a role for ALKBH5 in regulating the tumor immune microenvironment and immunotherapy efficacy. These findings suggest a new regulatory mechanism for PD-L1 involving mRNA epigenetic modification by ALKBH5, as well as a potential role for ALKBH5 in cancer immunotherapies.

CANCER RESEARCH (2021)

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Article Oncology

The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B-cell lymphoma and enhances T-cell recruitment

Hepei Yuan et al.

Summary: Tazemetostat can potentially activate anti-lymphoma response by upregulating CCL17 expression in B-cell lymphoma cells and promote T-cell recruitment, providing a rationale for its combination with immunotherapy.

CANCER SCIENCE (2021)

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Article Neurosciences

Histone-deacetylase 8 drives the immune response and the growth of glioma

Alessandro Mormino et al.

Summary: HDAC8 plays a key role in glioma growth and tumor microenvironment by regulating immune response. Inhibition of HDAC8 reduces tumor volume and controls glioma migration by increasing the acetylation of alpha-tubulin. Additionally, HDAC8 modulates the immunogenicity of the tumor microenvironment by regulating gene transcription of NKG2D ligands.

GLIA (2021)

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Article Biochemistry & Molecular Biology

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Zhenchuan Liu et al.

Summary: In this study, it was found that circIGF2BP3 contributes to immune escape in NSCLC by upregulating PKP3 expression and stabilizing OTUB1 mRNA to increase PD-L1 abundance. The impact on the CD8(+) T cell response was observed, shedding light on a novel mechanism of PD-L1 regulation in NSCLC and providing insight on enhancing the efficacy of anti-PD-1 treatment.

MOLECULAR CANCER (2021)

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Review Biochemistry & Molecular Biology

Going beyond Polycomb: EZH2 functions in prostate cancer

Su H. Park et al.

Summary: EZH2, a core subunit of PRC2, plays a crucial role in regulating cellular identity and stem cell maintenance through its histone methyltransferase activity. Dysregulation of EZH2 is frequently observed in various cancers, including prostate cancer. Despite some studies reporting its tumor suppressive and oncogenic functions, there are discrepancies in EZH2 and H3K27 methylation, and enzymatic inhibitors have shown limited efficacy in prostate cancer.

ONCOGENE (2021)

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Article Multidisciplinary Sciences

MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion

Abdulkhaleg Ibrahim et al.

Summary: Studies have shown that MeCP2 is a microsatellite DNA binding protein that specifically recognizes 5hmC-modified CA repeat sequences, maintaining nucleosome-free regions in the genome. Dysfunction of MeCP2 may play a role in Rett syndrome.

SCIENCE (2021)

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Article Multidisciplinary Sciences

METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells

Hao Song et al.

Summary: The m(6)A methylation protects the homeostasis and tumor immunosurveillance function of NK cells.

NATURE COMMUNICATIONS (2021)

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Article Biology

BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

Rafal Donczew et al.

Summary: The human BET proteins, targeted by Bdf1/2 in yeast, play critical roles in transcription initiation and early elongation, showing functional similarities to human BET proteins like Brd4. This provides important mechanistic insights into the function of BET proteins in all eukaryotes.

ELIFE (2021)

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Article Oncology

Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation

Ting Lu et al.

Summary: The study shows that NK cells can acquire TYRO3 from tumor cells via trogocytosis, resulting in enhanced cytotoxicity and IFNγ production. The activation status of NK cells and TYRO3 expression levels on donor cells correlate positively with trogocytosis levels.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Pharmacology & Pharmacy

YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma

Ganglin Su et al.

Summary: The study revealed that YTHDF2 may serve as a potential indicator of immune infiltration in KIRC and is associated with the overall survival and disease-free survival of patients.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Immunology

ARID1A, ARID1B, and ARID2 Mutations Serve as Potential Biomarkers for Immune Checkpoint Blockade in Patients With Non-Small Cell Lung Cancer

Guangsheng Zhu et al.

Summary: The research found that patients with ARID1A, ARID1B, and ARID2 mutations in the SWI/SNF complex in non-small cell lung cancer were more likely to benefit from immune checkpoint inhibitor therapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Genetics & Heredity

METTL14 Acts as a Potential Regulator of Tumor Immune and Progression in Clear Cell Renal Cell Carcinoma

Tianbo Xu et al.

Summary: The study identified the METTL14/CCL5/Tregs axis as a potential signaling pathway for regulating tumor immunity in ccRCC, and it could be novel therapeutic targets.

FRONTIERS IN GENETICS (2021)

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Article Multidisciplinary Sciences

m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity

Jing Zhou et al.

Summary: The m(6)A eraser ALKBH5 plays a crucial role in controlling the pathogenicity of CD4(+) T cells during autoimmunity, as its deficiency results in weakened immune responses and reduced recruitment of neutrophils into the central nervous system.

SCIENCE ADVANCES (2021)

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Article Oncology

m5C RNA Methylation Regulators Predict Prognosis and Regulate the Immune Microenvironment in Lung Squamous Cell Carcinoma

Junfan Pan et al.

Summary: The study revealed that m5C regulators are associated with prognosis and immune-related effects in lung squamous cell carcinoma (LUSC), especially NSUN3 and NSUN4, which are closely related to the infiltration of CD8+ T cells and neutrophils.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, General & Internal

m6A RNA Methylation Regulator YTHDF1 Correlated With Immune Microenvironment Predicts Clinical Outcomes and Therapeutic Efficacy in Breast Cancer

Ying Hu et al.

Summary: The dysregulation of m(6)A regulator YTHDF1 in breast cancer is related to poor prognosis. High expression of YTHDF1 is associated with cancer-related pathways and immune cells, as well as higher tumor mutation burden.

FRONTIERS IN MEDICINE (2021)

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Article Oncology

Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis

Qi Cui et al.

Summary: The study demonstrates that PUS7 controls tRNA pseudouridylation and codon-specific translation to promote glioblastoma tumorigenesis, and identifies a PUS7 inhibitor that delays tumor growth in glioblastoma models.

NATURE CANCER (2021)

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Article Oncology

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer

Kazuo Tsuchiya et al.

Summary: The study found that high expressions of both YTHDF1 and YTHDF2 are associated with a favorable prognostic outcome of NSCLC patients, a greater amount of TILs, and downregulation of PD-L1. These two proteins may be novel prognostic and druggable targets related to the tumor-immune microenvironment in lung cancers.

ONCOIMMUNOLOGY (2021)

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Article Oncology

Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer

Yuzhen Gao et al.

Summary: The study highlights the crucial role and potential impact of m(1)A modification patterns in the tumor microenvironment, particularly in influencing the prognosis of colon cancer patients and immune cell infiltration. The analysis of m(1)A score plays a significant role in understanding the complexities and diversity of the immune response in the context of cancer.

ONCOIMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis

Yao-Hui Huang et al.

Summary: Epigenetic alterations, especially mutations in genes related to histone modification, play a crucial role in tumor progression of DLBCL by influencing the tumor microenvironment, leading to increased tumor cell proliferation and polarization of M2 macrophages.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

Hao Liu et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Review Medicine, Research & Experimental

Epigenetic Regulation of m6A Modifications in Human Cancer

Wei Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Biochemistry & Molecular Biology

Modulation of SRSF2 expression reverses the exhaustion of TILs via the epigenetic regulation of immune checkpoint molecules

Ziqiang Wang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

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Review Oncology

Myeloid-derived suppressor cells-new and exciting players in lung cancer

Zhenzhen Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Oncology

Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β-catenin signaling

Xiaohui Tian et al.

MOLECULAR ONCOLOGY (2020)

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Review Gastroenterology & Hepatology

Epigenetics of colorectal cancer: biomarker and therapeutic potential

Gerhard Jung et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Oncology

SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors

Pooja Panwalkar et al.

NEURO-ONCOLOGY (2020)

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Article Multidisciplinary Sciences

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

Rebecca A. Luchtel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer

Sara Moufarrij et al.

SCIENTIFIC REPORTS (2020)

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Article Oncology

Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages

Dong Wang et al.

CANCER LETTERS (2020)

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Review Oncology

Natural killer T cell cytotoxic activity in cervical cancer is facilitated by the LINC00240/microRNA-124-3p/STAT3/MICA axis

Yan Zhang et al.

CANCER LETTERS (2020)

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Article Cell Biology

N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation

Xiaofei Gu et al.

CELLULAR SIGNALLING (2020)

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Article Oncology

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer

Varun Sasidharan Nair et al.

CLINICAL EPIGENETICS (2020)

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Article Genetics & Heredity

Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival

Hongbing Wu et al.

GENES AND IMMUNITY (2020)

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Article Cell Biology

High expression of WTAP leads to poor prognosis of gastric cancer by influencing tumour-associated T lymphocyte infiltration

Huafu Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Oncology

m6A-binding proteins: the emerging crucial performers in epigenetics

Yanchun Zhao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Oncology

Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment, in PTEN-Deficient Prostate Cancer

Di Zhao et al.

CANCER DISCOVERY (2020)

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Article Biochemistry & Molecular Biology

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Bo Zhang et al.

MOLECULAR CANCER (2020)

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Review Pharmacology & Pharmacy

The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy

Qiyao Yang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Cell Biology

Cytoplasmic m1A reader YTHDF3 inhibits trophoblast invasion by downregulation of m1A-methylated IGF1R

Qingliang Zheng et al.

CELL DISCOVERY (2020)

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Review Biochemistry & Molecular Biology

Towards a more precise therapy in cancer: Exploring epigenetic complexity

Fernando P. Cossio et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

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Article Oncology

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su et al.

CANCER CELL (2020)

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Article Oncology

Autocrine IL6-Mediated Activation of the STAT3-DNMT Axis Silences the TNFα-RIP1 Necroptosis Pathway to Sustain Survival and Accumulation of Myeloid-Derived Suppressor Cells

Alyssa D. Smith et al.

CANCER RESEARCH (2020)

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Article Microbiology

Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability

Kevin Tsai et al.

CELL HOST & MICROBE (2020)

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Review Immunology

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

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Hydrogen Sulfide Promotes Tet1-and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

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Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5

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The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications

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