☆ 4.7 Review

Macrophages in immunoregulation and therapeutics

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Review Medicine, General & Internal

Systemic sclerosis

Elizabeth R. Volkmann et al.

Summary: Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment options. Early and accurate diagnosis, as well as ongoing risk stratification, play a crucial role in predicting organ involvement and disease progression. Treatment should be tailored to individual patients, considering their goals of care, and balancing side effects with efficacy.

LANCET (2023)

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Review Oncology

The role and regulation of Maf proteins in cancer

Yalan Deng et al.

Summary: The Maf proteins, including large Mafs and small Mafs, are important transcription factors that play a vital role in various biological processes. Dysregulation of Mafs can lead to cell fate changes and is closely associated with different diseases, especially tumor development.

BIOMARKER RESEARCH (2023)

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Editorial Material Oncology

Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants

Semanti Mukherjee et al.

Summary: In this study, Wang et al. used whole-genome sequencing to comprehensively analyze common and rare variants associated with lung cancer risk in individuals with East Asian ancestry. Their findings suggest that rare promoter variants in the BRCA2 gene are associated with an increased risk of lung cancer.

CANCER CELL (2022)

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Review Chemistry, Multidisciplinary

Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy

Qing Li et al.

Summary: Recent studies have shown that myeloid-derived suppressor cells (MDSCs) play a crucial role in immune regulation within the tumor microenvironment. Targeting the metabolic vulnerabilities of MDSCs could serve as a novel strategy to improve the efficacy of immunotherapy for cancer.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Oncology

The functions and prognostic value of Kruppel-like factors in breast cancer

Ke-Yun Zhu et al.

Summary: KLF2 and KLF15 act as tumor suppressors in breast cancer and have potential as biomarkers for prognostic prediction in breast cancer patients.

CANCER CELL INTERNATIONAL (2022)

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Article Immunology

The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis

Yuan Yuan et al.

Summary: This study demonstrates the important role of KLF14 in regulating glycolysis and the immune function of macrophages during sepsis. KLF14 deletion leads to increased mortality in septic models. Mechanistically, KLF14 decreases glycolysis and the secretion of inflammatory cytokines by inhibiting the transcription of HK2.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Immunomodulatory functional foods and their molecular mechanisms

Jae Hwan Kim et al.

Summary: The immune system consists of innate and adaptive immunity, and chemical compounds in certain functional foods can influence immune function and provide protection against diseases.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

Youxiang Mao et al.

Summary: This study investigates the regulation and biological function of citrulline metabolism in the immune system. The researchers found that macrophage citrulline rapidly declines after interferon gamma and/or lipopolysaccharide stimulation, which is necessary for proinflammatory signaling activation. The study identifies ASS1 as a central player in controlling inflammatory macrophage activation and antibacterial defense by depleting cellular citrulline and reveals citrulline as a key metabolite in innate immune signaling.

MOLECULAR CELL (2022)

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Article Multidisciplinary Sciences

miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression

Chengxin Ma et al.

Summary: This study reveals the crucial role of the TGF beta/miR-182/TLR4 axis in the polarization of tumor-associated macrophages (TAMs) and provides a theoretical basis for RNA-based therapeutics targeting TAMs in cancer.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Medicine, Research & Experimental

Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury

Xiaomei Zhang et al.

Summary: This study reveals the critical role of BM-Mfs in sensing and responding to structural changes after irradiation injury, promoting vascular niche regeneration and enhancing hematopoietic reconstruction.

THERANOSTICS (2022)

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Article Chemistry, Multidisciplinary

Periosteal CD68+F4/80+ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1

Ruoxian Deng et al.

Summary: The research indicates that myeloid-lineage cells differentiate into subgroups and regulate periosteal bone formation in response to mechanical loading. Macrophages, a subtype of myeloid-lineage cells, play a crucial role in this process by activating TGF-beta 1 to recruit osteoprogenitors.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Colorectal Cancer-Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD-L1 Expression in Tumor-Associated Macrophages

Yuan Yin et al.

Summary: This study reveals that colorectal cancer cells can induce macrophage polarization and PD-L1 expression through the release of small extracellular vesicles (sEVs), leading to suppressed CD8(+) T cell activity and increased tumor growth. The miR-21-5p and miR-200a derived from sEVs play key regulatory roles in this process. Inhibiting the secretion of specific sEV-miRNAs from CRC and targeting PD-L1 in TAMs may serve as novel methods for CRC treatment.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Mouse Modeling Dissecting Macrophage-Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis

Anna-Katharina Mueller et al.

Summary: This study finds that macrophage infiltration in mammary tumors is associated with tumor progression, metastasis, and poor clinical outcome. Ablation of the TYRO3 kinase PYK2 can reduce the number of infiltrating macrophages, inhibit tumor angiogenesis and growth, and modulate monocyte recruitment, macrophage polarization, and tumor angiogenesis. Targeting PYK2 may be an effective strategy to modulate the tumor microenvironment and sensitize breast cancer to immunotherapy.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Single Cell RNA Sequencing Identifies a Unique Inflammatory Macrophage Subset as a Druggable Target for Alleviating Acute Kidney Injury

Weijian Yao et al.

Summary: This study reveals the complementary roles of kidney resident macrophages (KRMs) and monocyte-derived infiltrated macrophages (IMs) in modulating tissue inflammation and promoting tissue repair in ischemia reperfusion injury induced acute kidney injury (IRI-AKI). S100a9(hi)Ly6c(hi) IMs are identified as early responders to AKI, mediating the initiation and amplification of kidney inflammation. Targeting S100a8/a9 signaling with small-molecule inhibitors demonstrates renal protective effects.

ADVANCED SCIENCE (2022)

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Editorial Material Chemistry, Multidisciplinary

Comment on: The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ

Hanna S. Schymik et al.

Summary: This study provides initial insights into the regulation and role of IMP2 in macrophage activation. Differences in the regulation of IMP2 between inflammatory and anti-inflammatory macrophages were observed.

ADVANCED SCIENCE (2022)

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Article Immunology

The Route of Vaccine Administration Determines Whether Blood Neutrophils Undergo Long-Term Phenotypic Modifications

Yanis Feraoun et al.

Summary: The study demonstrates that different routes of immunization can lead to distinct innate cell responses, influencing the immune effects of vaccines. The vaccine per se is not enough to induce late phenotypic modifications of innate myeloid cells, emphasizing the importance of the route of administration in vaccination.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Functional and Therapeutic Significance of Tumor-Associated Macrophages in Colorectal Cancer

Yitong Li et al.

Summary: This article reviews the functional and therapeutic significance of tumor-associated macrophages (TAMs) in colorectal cancer (CRC). M1 macrophages suppress tumor growth while M2 macrophages promote CRC development. The polarization of TAMs is regulated by multiple pathways, and M2 polarization is controllable and reversible. Targeting TAMs may provide important therapeutic strategies for CRC.

FRONTIERS IN ONCOLOGY (2022)

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Review Engineering, Biomedical

Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries

Tianjiao Zhao et al.

Summary: This article discusses the biology and molecular mechanisms of myocardial ischemia reperfusion injury, and summarizes the application of ROS-based nanoparticles, highlighting the latest advances in nanotechnology research for the treatment of myocardial ischemia reperfusion injury.

BIOACTIVE MATERIALS (2022)

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Article Biology

The Role of TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target

Wanbin Hu et al.

Summary: This review summarizes the functions of Toll-like receptor 2 (TLR2) in innate immunity and metabolism, and suggests future research directions.

BIOLOGY-BASEL (2022)

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Article Peripheral Vascular Disease

Myeloid Piezo1 Deletion Protects Renal Fibrosis by Restraining Macrophage Infiltration and Activation

Yu He et al.

Summary: This study reveals the important role of Piezo1 in renal fibrosis, specifically in macrophages. The deletion of Piezo1 in macrophages can suppress macrophage inflammation, kidney fibrosis, and epithelial-mesenchymal transition. Targeting Piezo1 channels through genetic or pharmacological manipulations may be a promising approach for treating renal fibrosis.

HYPERTENSION (2022)

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Review Oncology

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Qinghua Wu et al.

Summary: Hypoxia in the tumor microenvironment weakens cytotoxic T cell function and promotes recruitment of regulatory T cells, thereby reducing tumor immunogenicity. Hypoxia-inducible factors (HIFs), especially HIF1A and HIF2A, play important roles in tumor immune escape through various mechanisms. Understanding these mechanisms can lead to the development of targeted therapies for tumor treatment.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity

Tuan Anh Phu et al.

Summary: The study found that THP1-IL4-exo can polarize macrophages to an anti-inflammatory phenotype and promote insulin uptake and browning of adipose tissue through changes in energy metabolism and miRNA expression. Experimental results in obese mice showed that THP1-IL4-exo can reduce inflammation and improve metabolism, suggesting its potential for treating cardiometabolic diseases and diabetes.

MOLECULAR THERAPY (2022)

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Review Oncology

Clinical relevance of tumour-associated macrophages

Mikael J. Pittet et al.

Summary: The interaction of tumour-associated macrophages (TAMs) with cancer and stromal cells in the tumour microenvironment enables and sustains most of the hallmarks of cancer. The authors of this Review examine the diversity of TAMs in various cancer indications, which is being revisited with the advent of single-cell technologies, and discuss the functional roles of different TAM states, the prognostic and predictive value of TAM-related signatures as well as approaches involving TAMs that are currently being or will soon be tested in clinical trials.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

MicroRNA-22 represses glioma development via activation of macrophage-mediated innate and adaptive immune responses

Jiajie Tu et al.

Summary: This study explores the potential clinical value and molecular mechanisms of miRNA-22 in tumor cell phagocytosis by macrophages and more efficient T cell priming. miR-22 upregulation enhances the phagocytic ability of macrophages, inhibits glioma cell proliferation and migration, and promotes antigen presentation and efficient T cell priming. The study also identifies HDAC6 as a target and NF-kappa B signaling as a pathway associated with miR-22 in tumor-associated macrophages of glioma.

ONCOGENE (2022)

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Article Nanoscience & Nanotechnology

Long-Term Controlled Growth Factor Release Using Layer-by-Layer Assembly for the Development of In Vivo Tissue-Engineered Blood Vessels

Febriyani F. R. Damanik et al.

Summary: The study combines surface-etched polymeric rods and layer-by-layer (LbL) coating to control the delivery of growth factors and generate functional vascular grafts in vivo. Results show that using TGF-beta 1 and TGF-beta 1/PDGF-BB releasing rods leads to the formation of tissue capsules rich in myofibroblasts and enhances the synthesis of collagen and elastin.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Cell Biology

MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH

Hong Gao et al.

Summary: Nonalcoholic steatohepatitis (NASH), a liver disease, is significantly associated with morbidity. Kupffer cells (KCs) produce endogenous miR-690 and transfer it to other liver cells via exosome secretion, leading to inhibition of fibrogenesis, inflammation, and de novo lipogenesis. Administration of an miR-690 mimic inhibits NASH phenotype features in mice. Lack of miR-690 in KCs and lower levels of miR-690 in NASH livers suggest its central role in NASH development. KC-specific knockout of miR-690 promotes NASH pathogenesis. miR-690 targets NADK mRNA, with NADK levels inversely proportional to cellular miR-690 content. These findings highlight the potential therapeutic role of miR-690 in treating NASH.

CELL METABOLISM (2022)

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Article Cell Biology

Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32

Jianbin Yin et al.

Summary: An imbalance in M1/M2 macrophage polarization plays a crucial role in the progression of osteoarthritis (OA). Pentraxin 3 (PTX3) is found to be highly expressed in OA M1-polarized macrophages and is involved in the occurrence and development of OA. PTX3 primarily affects OA through macrophages and the paracrine interaction between macrophages and chondrocytes produces a feedback loop that enhances synovitis and cartilage damage. This study identifies a functional pathway important to OA development and suggests that blocking this pathway and PTX3 may prevent and treat OA.

CELL DEATH & DISEASE (2022)

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Review Biochemistry & Molecular Biology

Macrophages Are a Double-Edged Sword: Molecular Crosstalk between Tumor-Associated Macrophages and Cancer Stem Cells

Shahang Luo et al.

Summary: This review comprehensively summarizes the mechanisms of interaction between cancer stem cells (CSCs) and tumor-associated macrophages (TAMs), and discusses potential therapeutic strategies. It is of great significance for understanding tumor progression and developing new treatment strategies.

BIOMOLECULES (2022)

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Article Cell Biology

Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1

Sheng Chen et al.

Summary: The tumor microenvironment (TME) is a unique niche where constant communication within and between intratumoral cellular compartments occurs, with intratumoral high potassium (K+) having a suppressive effect on T cells. However, the impact of this ionic disturbance on innate immunity, as a pan-cancer characteristic associated with local necrosis, is unknown. In this study, the researchers discovered that intratumoral high K+ suppresses the anti-tumor capacity of tumor-associated macrophages (TAMs). The inwardly rectifying K+ channel Kir2.1 was identified as a central modulator of TAM functional polarization in high K+ TME, and its conditional depletion led to TAM repolarization towards an anti-tumor state, thereby enhancing local anti-tumor immunity. Kir2.1 deficiency disrupted electrochemically dependent glutamine uptake, causing TAM metabolic reprogramming from oxidative phosphorylation to glycolysis. Blocking Kir2.1 attenuated both murine tumor and patient-derived xenograft growth. Overall, the findings suggest that Kir2.1 is a determinant and potential therapeutic target for restoring the anti-tumor capacity of TAMs within an ionic-imbalanced TME.

CELL METABOLISM (2022)

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Review Biochemistry & Molecular Biology

Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways

Serena Filiberti et al.

Summary: Macrophages are abundant immune cells in the tumor microenvironment, with crucial functions in cancer progression. Their plasticity and self-renewal ability are key factors in tumor development and therapy resistance. Additionally, macrophage metabolism and TAM proliferation are influenced by microenvironmental factors.

BIOMEDICINES (2022)

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Article Multidisciplinary Sciences

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity

Sushrut Kamerkar et al.

Summary: Researchers have developed an engineered exosome therapeutic candidate that selectively silences the expression of STAT6 gene in tumor-associated macrophages (TAMs). This drug shows high efficacy in inhibiting tumor growth and inducing complete remissions in colorectal cancer and hepatocellular carcinoma models. It also remodels the tumor microenvironment and triggers a specific immune response mediated by CD8 T cells.

SCIENCE ADVANCES (2022)

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Article Immunology

Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation

Tim Bleul et al.

Summary: The study investigated immunological differences and the role of CD38+/F4/80 + M1 macrophages in C57BL/6J and BALB/c recipient mouse corneal transplantation models. It was found that both strains of mice exhibited rejection of allogeneic corneal transplants, with more pronounced tissue alterations in C57BL/6J recipients. Following syngeneic transplantation, C57BL/6J recipients showed persistent graft swelling with increased numbers of CD38+/F4/80 + M1 macrophages in the grafted tissue, in contrast to BALB/c recipients. The results suggest that strain-dependent differences lead to different innate immune responses in BALB/c and C57BL/6J strains, and careful consideration of both donor and recipient mouse lines is essential for murine keratoplasty experiments. C57BL/6J-recipient mice may be particularly suited for studying corneal graft rejection in high-risk clinical settings.

JOURNAL OF INNATE IMMUNITY (2021)

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Review Genetics & Heredity

Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases

Antero Salminen

Summary: 1. Low-grade inflammation is associated with aging and age-related diseases. 2. Persistent inflammation activates compensatory immunosuppression with aging. 3. The numbers of immunosuppressive cells increase with aging and age-related diseases. 4. Immunosuppressive mechanisms evoke harmful bystander effects in host tissues. 5. Immunosuppression promotes tissue degeneration with aging and age-related diseases.

JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

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Article Chemistry, Multidisciplinary

Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling

Naibo Feng et al.

Summary: The study investigates the use of siRNA drugs targeting the ERN1 gene for the treatment of autoimmune inflammatory diseases. The developed nanodrug delivery system demonstrates efficient targeting and therapeutic effects in mouse models of arthritis and inflammatory bowel disease.

ACS NANO (2021)

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Article Oncology

Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective

Egle Ramelyte et al.

Summary: The study found that intralesional T-VEC treatment in primary cutaneous B cell lymphoma patients led to significant tumor response, rapid eradication of malignant cells, activation of the interferon pathway, and early influx of various immune cells, ultimately resulting in enhanced cellular immunity.

CANCER CELL (2021)

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Article Biochemistry & Molecular Biology

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Timothy N. Hoang et al.

Summary: The study found that in a rhesus macaque model of SARS-CoV-2 infection, baricitinib did not reduce viral shedding, but did decrease inflammation and suppress the production of cytokines and chemokines, suggesting its potential as an effective treatment for COVID-19 inflammation.

CELL (2021)

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Review Biochemistry & Molecular Biology

The versatile biochemistry of iron in macrophage effector functions

Jacques Behmoaras

Summary: Macrophages are mononuclear phagocytes with remarkable polarization ability that allow them to have tissue-specific functions during development, homeostasis, inflammatory and infectious disease. One particular trophic factor in the tissue environment is iron, which is intimately linked to macrophage effector functions. Haemoproteins, dioxygenases and iron-sulphur (Fe-S) enzymes are crucial iron-binding proteins that play essential roles in shaping the context-dependent macrophage polarization. Iron, as part of haem or Fe-S clusters, participates in regulating pro-inflammatory redox reactions and enzymatic cofactor functions, highlighting a coordinated regulation of haemoproteins and Fe-S enzymes during classical macrophage activation. Tryptophan and alpha-ketoglutarate metabolism are identified as two essential effector pathways in macrophages using diverse iron biochemistry at different enzymatic steps, showing how iron is involved in regulating essential metabolites to shape macrophage function.

FEBS JOURNAL (2021)

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Article Oncology

S100 calcium-binding protein A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma

Ran Wei et al.

Summary: The study revealed that TAMs can enhance the stem cell-like properties of HCC cells by upregulating the secreted protein S100A9, which in turn activates the NF-kB signaling pathway. Additionally, S100A9 can promote the recruitment of macrophages to HCC cells, suggesting a positive feedback loop between TAMs and HCC cells.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Review Biochemistry & Molecular Biology

Emerging Functions for snoRNAs and snoRNA-Derived Fragments

Maliha Wajahat et al.

Summary: The widespread use of mass sequencing has uncovered a diverse landscape of small RNAs derived from larger precursors, with stable fragments derived from non-coding RNAs such as tRNAs, rRNAs, and snoRNAs. Experimental evidence suggests that small non-coding RNAs have biological significance beyond miRNAs and piRNAs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Statins and Bempedoic Acid: Different Actions of Cholesterol Inhibitors on Macrophage Activation

Rebecca Linnenberger et al.

Summary: Statins have immunomodulatory effects on macrophage polarization, while bempedoic acid treatment does not exhibit similar impacts.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

The inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal

Adriana Valeria Jager et al.

Summary: This study elucidated the modulation of macrophage efferocytic function during an inflammatory stimulus. The results showed that macrophages efficiently engulf bacterial pathogens and apoptotic cells, and their efferocytic capacity increased significantly after processing bacteria. Furthermore, the study demonstrated that bacterial processing enhanced the efferocytosis of macrophages through the IL-6 signaling pathway.

SCIENTIFIC REPORTS (2021)

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Review Cell & Tissue Engineering

Biomaterial-supported MSC transplantation enhances cell-cell communication for spinal cord injury

Bin Lv et al.

Summary: The spinal cord connects the brain to the peripheral nervous system and peripheral tissues through neurons and various types of glial cells. Neurons in the spinal cord process sensory input and control movement. Neurodegenerative disorders and traumatic injuries affecting the spinal cord result in motor deficits and loss of sensory inputs.

STEM CELL RESEARCH & THERAPY (2021)

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Review Geriatrics & Gerontology

Macrophage function in the elderly and impact on injury repair and cancer

L. Duong et al.

Summary: As individuals age, their health deteriorates, leading to an increased risk of diseases such as cancer. The process of immunosenescence is characterized by changes in immune function, including an imbalance between pro-inflammatory and anti-inflammatory factors. Macrophages, key inflammatory cells, play a significant role in aging processes, potentially impacting the severity of age-related diseases such as cancer and injury repair.

IMMUNITY & AGEING (2021)

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Review Allergy

How to detect eosinophil ETosis (EETosis) and extracellular traps

Mineyo Fukuchi et al.

Summary: Eosinophils, although a small population, play multifunctional roles in homeostasis and diseases, including releasing eosinophil extracellular traps leading to cell death. Recent studies suggest a close association between EETosis and the classical pathological feature of eosinophilic inflammation, Charcot-Leyden crystals. While there is currently no gold standard for identifying EETosis, the release of cell contents may be a common feature.

ALLERGOLOGY INTERNATIONAL (2021)

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Review Immunology

The Role of Macrophages in Staphylococcus aureus Infection

Grace R. Pidwill et al.

Summary: Staphylococcus aureus, a member of human commensal microflora, can cause serious diseases by circumventing the innate immune system and establishing infections. Professional phagocytes like macrophages and neutrophils play key roles in containing and resolving S. aureus infections, while the bacteria have evolved multiple strategies to survive, manipulate, and escape from macrophages. Understanding the interactions between macrophages and S. aureus may be beneficial for future therapeutic developments.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming

Sen Yang et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that can only be cured by surgery in its early stages, but recurrence remains a high possibility. Tumor-associated macrophages (TAMs) play a crucial role in PDAC development, promoting tumor behaviors such as tumorigenesis and metastasis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Oncology

Metabolic reprogramming in macrophage responses

Yang Liu et al.

Summary: Macrophages are key regulators of tissue homeostasis, involved in tissue development, repair, and defense against pathogens. TAMs play a crucial role in the tumor microenvironment, impacting tumor initiation, growth, invasion, and metastasis. The metabolic characteristics of macrophages influence their phenotype and function, with pro-inflammatory M1 macrophages relying on glycolysis and anti-inflammatory M2 macrophages more dependent on mitochondrial OXPHOS.

BIOMARKER RESEARCH (2021)

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Article Multidisciplinary Sciences

PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

Hannah Wilkinson et al.

Summary: Research has shown that in chronic inflammation, the PAR-1 signal is crucial for granuloma formation, with this signal acting on macrophages through the activation of Thrombin. The results of the experiment indicate that Thrombin signaling significantly enhances macrophage sensitivity to IFN-γ, leading to enhanced cell polarization.

ISCIENCE (2021)

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Review Chemistry, Multidisciplinary

Tailoring Materials for Modulation of Macrophage Fate

Jinhua Li et al.

Summary: This review focuses on the design strategies and principles of immunomodulatory biomaterials to regulate macrophage fate, as well as their potential applications in various immunengineering fields. The tunability of material designs, including physical, chemical, biological, and dynamic cues, plays a crucial role in modulating macrophage immune response. The selected immunoengineering applications demonstrate how macrophage-immunomodulating biomaterials are being utilized for cancer immunotherapy, infection immunotherapy, tissue regeneration, inflammation resolution, and vaccination.

ADVANCED MATERIALS (2021)

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Article Biochemistry & Molecular Biology

A role of PIEZO1 in iron metabolism in mice and humans

Shang Ma et al.

Summary: Iron overload can cause progressive organ damage and is associated with genetic factors affecting iron homeostasis. Certain individuals with hereditary disorders may develop iron overload, and some GOF PIEZO1 alleles are linked to iron imbalance. The study demonstrates the key role of PIEZO1 in macrophage phagocytic activity and iron metabolism, with a particular GOF PIEZO1 allele showing a strong association with increased plasma iron levels in individuals of African descent.

CELL (2021)

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Review Biochemistry & Molecular Biology

How Macrophages Become Transcriptionally Dysregulated: A Hidden Impact of Antitumor Therapy

Galina F. Medvedeva et al.

Summary: Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment, and their function is closely related to transcription factors such as STAT1, NF-kappa B, IRF, which affect tumor adaptation and resistance to radio- and chemotherapy, serving as important biomarkers for theranostics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

Guangan Hu et al.

Summary: Macrophages exhibit plasticity and can polarize into various phenotypes in response to different stimuli. Through high-throughput screening of a library of around 4000 compounds, researchers identified compounds that can activate human macrophages towards specific polarization states, with some capable of reprogramming macrophages between different states. Transcriptional analysis helped uncover the pathways and targets through which these compounds modulate macrophage activation.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Alba Rodriguez-Garcia et al.

Summary: The study demonstrates that targeting FR beta-expressing TAMs with CAR-T cells can enhance antitumor immune responses and improve the efficacy of adoptive T-cell therapy in pre-clinical models.

NATURE COMMUNICATIONS (2021)

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Review Chemistry, Physical

The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials

Andreea-Mariana Negrescu et al.

Summary: The immune system and bone-forming cells have been found to be closely connected through various signaling molecules and receptors, affecting the host immune reaction triggered by biomaterial implantation. The traditional inert biomaterial design for stimulating osteogenesis has shifted towards implants with osteoimmunomodulatory properties to trigger a desired immune response for proper bone regeneration. Various approaches, such as modifying chemical/structural characteristics or incorporating bioactive molecules, have been employed to modulate the crosstalk with immune cells in orthopedic biomaterials.

MATERIALS (2021)

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Review Immunology

The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy

Retsepile E. Maphasa et al.

Summary: This review focuses on macrophage responses to Mtb infection, particularly the mechanistic aspects of autophagy and how intracellular Mtb evades autophagy. The relationship between autophagy and apoptosis is also discussed, along with known autophagy inducing compounds for Mtb infection. The use of nanoparticles to induce autophagy is explored as a potential avenue for further research into nanomedicine HDTs for TB therapy.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Cell Biology

TCF4 enhances hepatic metastasis of colorectal cancer by regulating tumor-associated macrophage via CCL2/CCR2 signaling

Wei Tu et al.

Summary: Colorectal cancer liver metastasis is a significant clinical problem, and tumor-associated macrophage (TAM) recruitment and M2 polarization are closely associated with elevated TCF4 expression in the metastatic site. TCF4 deficiency reduces TAM infiltration and M2 polarization, mediated by the regulated CCL2 and CCR2 expression. These findings suggest that the TCF4-CCL2-CCR2 axis plays a crucial role in CRC liver metastasis by enhancing TAMs recruitment and M2 polarization.

CELL DEATH & DISEASE (2021)

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Review Multidisciplinary Sciences

Emerging technologies and infection models in cellular microbiology

Ana Teresa Lopez-Jimenez et al.

Summary: Cellular microbiology, a field that studies intracellular pathogens and their manipulation of host cells, has seen recent advances in technologies and infection models that are driving the development of new strategies for combating infections and improving human health. A focus on microscopy, robotics, artificial intelligence, and advanced imaging techniques has led to a deeper understanding of the host-pathogen interface and the infection process within cells, offering promising opportunities for future medical advancements.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model

Tingxuan Gu et al.

Summary: This study investigates the mechanism of cytokine storm syndrome (CSS) in COVID-19 and explores potential therapeutic options. TNF-α and IL-6 are suggested to play a role in the occurrence of CSS. The use of certain monoclonal antibodies and inhibitors shows promise in alleviating symptoms of CSS.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Modulation of Immune Responses by Particle Size and Shape

Maksim V. Baranov et al.

Summary: The size, shape, rigidity, and surface roughness of pathogens are important parameters affecting cellular uptake and immune responses, particularly in inflammasome activation and T cell activation. Understanding how the physical properties of particles influence immune responses can assist in the design of more effective vaccines.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Oncology

TAM Receptor Inhibition-Implications for Cancer and the Immune System

Pia Aehnlich et al.

Summary: TAM receptors are crucial in the digestion of dying cells by macrophages and in balancing immune responses. Inhibition of TAM signaling in cancer cells shows promise as a therapeutic target, but may also compromise anticancer immune responses due to conflicting roles of TAM signaling in innate cells and T cells.

CANCERS (2021)

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Review Multidisciplinary Sciences

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Rani Mata et al.

Summary: Tissue regeneration involves a dynamic inflammatory microenvironment, where inflammation plays a crucial role in immune system and tissue repair under normal conditions but can cause diseases if dysregulated. Understanding inflammatory responses and cellular metabolisms can facilitate advancements in therapeutic methods.

RESEARCH (2021)

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Review Cell Biology

Roles of Macrophages in the Development and Treatment of Gut Inflammation

Xuebing Han et al.

Summary: Macrophages in the intestinal tract play a crucial role in maintaining microbial homeostasis and renewing intestinal epithelial cells, as well as participating in the development of intestinal inflammation. Understanding their functions and roles in inflammatory responses will be crucial for advancing treatments of intestinal inflammatory diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Immunology

Targeting Innate Immunity in Cancer Therapy

Srikrishnan Rameshbabu et al.

Summary: The majority of cancer immunotherapy strategies focus on enhancing antitumor adaptive immune responses, but the efficacy is limited to a small fraction of patients within certain tumor types. Novel approaches to activate innate immunity within the tumor microenvironment to improve antitumor immune responses have emerged, as well as rational combination strategies to activate both innate and adaptive immunity for enhanced therapeutic efficacy.

VACCINES (2021)

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Review Oncology

MiRNA-mediated EMT and CSCs in cancer chemoresistance

Bing Dong et al.

Summary: Cancer stem cells (CSCs) play a crucial role in tumorigenesis and cancer progression, with their generation believed to be driven by epithelial-to-mesenchymal transition (EMT). MicroRNAs (miRNAs) have been found to be key players in this process, and regulating miRNAs associated with EMT or CSCs may help overcome drug resistance.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

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Article Nanoscience & Nanotechnology

Immunomodulatory Scaffolds Derived from Lymph Node Extracellular Matrices

Yi Sun Choi et al.

Summary: Lymph node extracellular matrix (LNEM) can mimic lymph node microenvironments and enhance immunomodulatory effects, promoting M2 macrophage polarization and secretion of anti-inflammatory cytokines. In a 3D LNEM environment, macrophage phagocytic function is improved, showing potential for drug testing and tissue healing applications. LNEM hydrogel implantation facilitates macrophage recruitment and polarization towards M2 phenotype for tissue healing, indicating the utility of 3D immune system-mimicking biomaterials in tissue modeling and regenerative medicine.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Engineering, Biomedical

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

Karen E. Martin et al.

Summary: Macrophages are crucial for tissue repair and regenerative medicine, with recent studies indicating the importance of both M1 and M2 phenotypes. Technological advancements like single-cell RNA sequencing provide insights into macrophage heterogeneity, aiding in the rational design of biomaterials. Understanding the diverse roles of macrophages in tissue repair processes is essential for improving biomaterial-tissue integration and regeneration.

ACTA BIOMATERIALIA (2021)

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Article Biology

Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis

Daan Vorselen et al.

Summary: The study reveals that during macrophage phagocytosis of antibody-opsonized targets, there is a prominent constriction driven by Arp2/3-mediated assembly of discrete actin protrusions. Contractile myosin-II activity contributes to late-stage phagocytic force generation and target ingestion. Observations of partial target eating attempts and sudden target release suggest that constriction may play a critical role in resolving complex in vivo target encounters.

ELIFE (2021)

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Article Immunology

Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects

Wen-Teng Chang et al.

Summary: The study identified multiple transcription factor binding sites on the IL-6 promoter, with dexamethasone reducing LPS-induced IL-6 production. The second GR binding site was found to play a crucial role in inflammation induced by LPS.

BMC IMMUNOLOGY (2021)

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Article Cell Biology

Tumor-associated macrophage-derived CCL5 promotes chemotherapy resistance and metastasis in prostatic cancer

Jian Ma et al.

Summary: The interaction between tumor microenvironment and cancer cells plays a crucial role in tumor progression. In this study, it was found that tumor-associated macrophages (TAMs) enriched in chemoresistant prostatic tumor tissues can promote chemoresistance and distant metastasis through secretion of CCL5. Mechanistically, TAMs and CCL5 mediate STAT3-dependent epithelial-mesenchymal transition process, resulting in distant metastasis and drug resistance in prostatic cancer.

CELL BIOLOGY INTERNATIONAL (2021)

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Review Genetics & Heredity

Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function

Lidia Fortuny et al.

Summary: Cellular metabolism plays a crucial role in controlling various physiological processes besides converting nutrients into energy and biomass. Specific metabolic pathways are associated with different immune cell types, affecting their differentiation, proliferation, and effector functions, which in turn shape the immune response against pathogens and tumors. Mammalian sirtuins have been identified as important regulators of cellular metabolism, immune cell function, and cancer.

GENES (2021)

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Review Immunology

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury

Zaib A. Shaheryar et al.

Summary: Ischemic stroke is a major cause of mortality and morbidity globally, but there is currently no definitive and effective treatment. Various treatment options have been proposed, but targeting the intricate intracellular signaling pathways of the 'neuroinflammatory triangle' may be more pragmatic in limiting post-stroke damage and disabilities.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Monocytes, Macrophages, and Their Potential Niches in Synovial Joints - Therapeutic Targets in Post-Traumatic Osteoarthritis?

Patrick Haubruck et al.

Summary: Synovial joints are complex structures in the human body that are susceptible to inflammatory responses and increased risk of osteoarthritis following injury. Macrophages play a crucial role in healthy joints, working in coordination with synovial fibroblasts to maintain joint functionality. Perturbations in cellular interactions, particularly induced by joint injury, can contribute to osteoarthritis pathogenesis, highlighting the importance of understanding these mechanisms for potential therapeutic interventions.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review

Ali Ataya et al.

Summary: The article reviews the role of GM-CSF in aPAP pathogenesis and pulmonary homeostasis, as well as the increased incidence of infections.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Th17 Cells Provide Mucosal Protection against Gastric Trypanosoma cruzi Infection

Catherine W. Cai et al.

Summary: Recent studies have shown that Th17 cells and IL-17A play important roles in immunity to Trypanosoma cruzi infection, particularly in the mucosa where the parasite initially invades. These cells induce NADPH oxidase activity to provide protection against mucosal T. cruzi infection.

INFECTION AND IMMUNITY (2021)

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Review Oncology

Interaction of Opioids with TLR4-Mechanisms and Ramifications

Mai Mahmoud Gabr et al.

Summary: Recent evidence suggests that opioids can interact with the Toll-like receptor 4 (TLR4) on innate immune and cancer cells, potentially influencing tumor growth and metastasis. Opioids have been shown to weakly activate TLR4 and can inhibit its activation by lipopolysaccharide (LPS). The interaction of opioids with TLR4 is complex, involving non-competitive mechanisms and downstream effects on NF-kappa B activation.

CANCERS (2021)

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Review Cell Biology

Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO

Khosrow Kashfi et al.

Summary: Nitric oxide production by iNOS plays a critical role in tumor promotion or suppression through influencing macrophage polarization. Manipulating macrophage plasticity to enhance tumoricidal defenses is a potential therapeutic strategy in cancer treatment. Regulatory pathways and immunomodulation targeting macrophage polarization may inhibit the immunosuppressive tumor microenvironment.

CELLS (2021)

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Review Engineering, Biomedical

Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization

Jinchun Ye et al.

Summary: Studies have shown that active modulation of immune cells, particularly macrophages, via biomaterials is an effective way to control immune response, promote tissue regeneration, and facilitate biomaterial integration.

BIOACTIVE MATERIALS (2021)

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Review Oncology

Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy

Zhaonian Hao et al.

Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.

BIOMARKER RESEARCH (2021)

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Review Oncology

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Shangli Zhu et al.

Summary: Macrophages are heterogeneous cells that can be classified into M1- and M2-like phenotypes, with M2-like macrophages playing a critical role in tumor microenvironment. They contribute to tumor progression by promoting tumor cell proliferation, angiogenesis, and immunosuppression.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

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Article Multidisciplinary Sciences

The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis

Michio Sato et al.

Summary: The cytoplasmic lncRNA Caren decreases translation of a distant gene encoding Hint1, maintaining cardiomyocyte function and protecting cardiac function under pathological stress by inactivating the DNA damage response and activating mitochondrial bioenergetics.

NATURE COMMUNICATIONS (2021)

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Article Oncology

Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer

Owen Heath et al.

Summary: The study suggests that neoadjuvant chemotherapy may shift the TAM population in HGSOC towards an anti-tumor phenotype that could benefit adaptive immune responses. Therapies aimed at enhancing or sustaining this phenotype during remission may help delay relapse.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Genetics & Heredity

Tumor-Associated Macrophage Promotes the Survival of Cancer Cells upon Docetaxel Chemotherapy via the CSF1/CSF1R-CXCL12/CXCR4 Axis in Castration-Resistant Prostate Cancer

Wei Guan et al.

Summary: The study found that TAM activates CXCR4 by increasing secreted CXCL12, enhancing the survival of cancer cells and elucidating the mechanism of TAM in chemotherapy. This finding may aid in the development of new drugs to overcome immune tolerance in castration-resistant prostate cancer.

GENES (2021)

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Review Immunology

Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes

Tiffany Davia Ricketts et al.

Summary: This article discusses the roles of macrophages in tumors, with tumors exploiting macrophage characteristics to promote tumor growth. By preventing macrophages from adopting a pro-tumor phenotype or reprogramming them to a pro-inflammatory state, it may be possible to inhibit tumor growth.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Nanocomplex-Mediated In Vivo Programming to Chimeric Antigen Receptor-M1 Macrophages for Cancer Therapy

Mikyung Kang et al.

Summary: The study proposes a simple method to transform macrophages that can naturally infiltrate solid tumors into CAR-M1 macrophages with enhanced cancer-directed phagocytosis and anti-tumor activity. Injected nanocomplexes of macrophage-targeting nanocarriers and CAR-interferon-gamma-encoding plasmid DNA induce CAR-M1 macrophages capable of CAR-mediated cancer phagocytosis, tumor immunomodulation, and inhibiting solid tumor growth, providing an effective off-the-shelf CAR-macrophage therapy for solid tumors without the need for complex and costly ex vivo CAR-cell manufacturing processes.

ADVANCED MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses

Pengpeng Xia et al.

Summary: This paper summarizes the specificity of TLRs in recognizing microbial components, discusses their role in regulating immune responses, and proposes a novel therapeutic strategy using TLRs to combat microbial infections.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Review Cell Biology

Metabolic orchestration of the wound healing response

Sabine A. Eming et al.

Summary: Macrophages play a central role in wound healing, with inflammatory macrophages responding to initial wound stimuli and alternatively activated macrophages essential for wound closure. Metabolic changes in macrophages have significant effects on their functional states, and the metabolic interplay between macrophages and fibroblasts is crucial for wound healing.

CELL METABOLISM (2021)

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Review Rheumatology

Contribution of monocytes and macrophages to the pathogenesis of systemic sclerosis: recent insights and therapeutic implications

Alain Lescoat et al.

Summary: Recent studies have highlighted the critical role of monocytes and macrophages in the pathogenesis of systemic sclerosis (SSc), showing increased monocyte adhesion and the presence of new macrophage subpopulations. Impaired pro-resolving capacities of macrophages may also contribute to the inflammatory and autoimmune features of SSc, making macrophages a potential target for therapeutic interventions. Investigative drugs targeting macrophage polarization have shown promising results in preclinical models and clinical trials, suggesting a potential novel approach for the treatment of SSc and other fibro-inflammatory disorders.

CURRENT OPINION IN RHEUMATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Regulatory Macrophages and Tolerogenic Dendritic Cells in Myeloid Regulatory Cell-Based Therapies

Maaike Suuring et al.

Summary: Myeloid regulatory cell-based therapy, focusing on generating tolerogenic dendritic cells (tolDCs) and regulatory macrophages (Mregs), has shown great potential in organ transplantation and autoimmune diseases. These cells are produced ex vivo using various differentiation signals and stimuli, with studies in animals and humans leading to clinical trials for therapeutic applications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cardiac & Cardiovascular Systems

PPAR control of metabolism and cardiovascular functions

David Montaigne et al.

Summary: Novel PPAR agonists offer new opportunities for managing metabolic and cardiovascular diseases by regulating gene expression, lipid metabolism, insulin sensitivity, glucose metabolism, and cardiovascular health. Activation of PPARs by specific ligands can have antiatherogenic, anti-inflammatory, and metabolic benefits, making them important therapeutic targets in the treatment of various diseases.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Cell Biology

Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway

Anna Santarsiero et al.

Summary: Phenolic compounds in red wine powder show potential immunomodulatory and anti-inflammatory effects by reducing proinflammatory cytokines secretion, restoring Annexin A1 levels, lowering NF-kappa B activity, and regulating metabolic genes involved in the citrate pathway, ultimately leading to suppression of inflammatory pathways and activation of proresolutive processes in macrophages.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Virology

The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner

Victoria Callahan et al.

Summary: The study shows that SARS-CoV-2 infection induces an inflammatory state in human lung epithelial cells with elevated levels of pro-inflammatory chemokines and cytokines. Inhibition of the AKT pathway may reduce the induction of these chemokines, potentially providing specific targets for mitigating SARS-CoV-2 pathogenesis associated with hyperinflammation.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

Jing Geng et al.

Summary: TLR4 signaling enhances macrophage bactericidal activity through the mechanical sensor Piezo1, with mechanical sensing signals playing a critical role in the innate immune response. The assembly of Piezo1 and TLR4 complex triggers the remodeling of F-actin organization to augment phagocytosis and bacterial clearance, providing insights into macrophage mechanophysiology and host response coordination.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

Chia-Ching Lin et al.

Summary: TUT7 is induced upon TLR4 activation in macrophages and plays a key role in sculpting inflammatory responses by modulating mRNA stability of selected inflammatory mediators, such as IL-6.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Hamza Atcha et al.

Summary: Studies reveal that Piezo1 serves as a mechanosensor of stiffness in macrophages, influencing their polarization responses.

NATURE COMMUNICATIONS (2021)

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Review Immunology

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Noymar Luque-Campos et al.

Summary: MSCs, multipotent adult stromal cells, are widely studied for their regenerative and immunomodulatory properties, capable of modulating macrophage plasticity and function. Metabolic changes can also affect macrophage fate and function, prompting phenotype change in response to environmental cues. Understanding the crosstalk between macrophages and MSCs can improve therapeutic potential in inflammatory diseases, cancer, and tissue repair processes.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Role of microRNAs and Long Non-Coding RNAs in the Regulation of the Immune Response to Mycobacterium tuberculosis Infection

Manikuntala Kundu et al.

Summary: Non-coding RNAs, including miRNAs and lncRNAs, play crucial roles in the host immune response to tuberculosis infection, regulating host defense mechanisms and impacting the outcome of infection. miRNAs are involved in regulating host signaling pathways linked to inflammation, autophagy, apoptosis, and macrophage polarization upon infection with M. tuberculosis, while lncRNAs interact with chromatin remodelers, regulate gene expression, and function as miRNA sponges.Targeting miRNAs is an emerging option for host-directed therapies, and understanding the role of non-coding RNAs is essential for the development of RNA-based thera

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Identifying Immune Cell Infiltration and Effective Diagnostic Biomarkers in Rheumatoid Arthritis by Bioinformatics Analysis

Sheng Zhou et al.

Summary: Through bioinformatics analysis, CCL5, CXCR4, GZMA, and CD8A were identified as diagnostic biomarkers for RA and their association with different immune cells was determined. Particularly, GZMA-Tfh cells may play a role in the early pathogenesis of RA.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis

Jie Huang et al.

Summary: Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that affects a significant portion of the global population. While progress has been made with disease-modifying antirheumatic drugs, there is still a need for new therapeutic targets and approaches for some patients with limited response to existing treatments.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Macrophages: The Good, the Bad, and the Gluttony

Ewan R. A. Ross et al.

Summary: Macrophages play critical roles in sterile inflammation and autoimmune diseases, particularly in the pathophysiology of diseases like rheumatoid arthritis. Imbalance in macrophage homeostasis contributes to chronic inflammation, and therapeutic strategies targeting macrophage plasticity are being explored. Apoptotic cell-derived extracellular vesicles may play a role in regulating macrophage phenotype and are a potential target for new therapeutic approaches.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-Inflammatory Cytokines

Shreya Ahuja et al.

Summary: The study investigated the tumor-supportive biological processes activated in microglia cells in response to anti-inflammatory cytokines released from cancer cells using mass spectrometry and proteomic technologies. The results showed that stimulation with anti-inflammatory cytokines led to the activation of tumor-promoting biological processes in microglia cells.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

Andrew J. Monteith et al.

Summary: This study demonstrates that S100A9-deficient neutrophils display increased levels of suicidal NETosis in response to extracellular pathogens, leading to enhanced antibacterial activity by promoting macrophage killing and transferring antimicrobial peptides.

SCIENCE ADVANCES (2021)

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Review Medicine, General & Internal

Myeloid-Derived Suppressor Cells and Mesenchymal Stem/Stromal Cells in Myeloid Malignancies

Suncica Kapor et al.

Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer

Alba Loras et al.

Summary: Current diagnostic and follow-up methods for bladder cancer have limitations and there is a need for non-invasive biomarkers. Personalized treatments can improve patient quality of life and overall survival. The interplay between epigenetics and metabolism is closely linked to tumor phenotype, providing valuable insights for researchers and clinical decision-making in the field of bladder cancer.

CANCERS (2021)

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Review Oncology

Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Therapeutic Opportunities and Clinical Challenges

Ashleigh R. Poh et al.

Summary: Macrophages play a crucial role in the pancreatic tumor microenvironment and are associated with poor patient survival. Pre-clinical studies have shown the diverse contributions of macrophages in PDAC development, however, the effectiveness of macrophage-targeting therapies in clinical trials is inconsistent.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Nanoparticles to Target and Treat Macrophages: The Ockham's Concept?

Mireia Medrano-Bosch et al.

Summary: Nanoparticles, with their tunable physical, chemical, and biological characteristics, have gained attention in technological advances. Challenges remain in the administration of nanoparticles to living beings due to rapid detection and clearance by the mononuclear phagocytic system. Current research is focused on designing nanoparticles for specific targeting of macrophages in diseased tissues.

PHARMACEUTICS (2021)

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Review Cell Biology

Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor-Glioma Therapy?

Ni Tong et al.

Summary: TAMs play a crucial role in the progression of glioma, and treatment strategies targeting TAMs include inhibiting recruitment, reducing viability, and altering phenotype. Research progress has shown the potential effectiveness of anti-tumor therapy targeting TAMs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Microbiology

The Role of Macrophages in the Host's Defense against Sporothrix schenckii

Estela Ruiz-Baca et al.

Summary: The role of immune cells in sporotrichosis caused by Sporothrix schenckii is not fully understood. Macrophages recognize PAMPs of Sporothrix through PRRs and control infection by engulfing, activating respiratory burst, and secreting biological mediators. Characteristics of S. schenckii and/or the host may influence macrophage polarization and immune response.

PATHOGENS (2021)

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Article Biochemistry & Molecular Biology

Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism

Mengwen Zhang et al.

Summary: The study revealed that pancreatic ductal adenocarcinoma (PDA) tumor cells induce DNA methylation and downregulation of glucose metabolism genes selectively in M1-like macrophages, leading to their phenotypic reprogramming into M2-like macrophages. This process is mediated by GARP and integrin alpha V/beta 8 and results in the acquisition of pro-cancerous capabilities by M1-like macrophages through Il-10 activation. The research suggests that PDA cells can reprogram M1-like macrophages metabolically and functionally through DNA methylation to adopt a pro-cancerous fate.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Inflammation and tumor progression: signaling pathways and targeted intervention

Huakan Zhao et al.

Summary: Inflammation plays a crucial role in cancer development and therapy, either promoting or inhibiting tumor progression and therapeutic outcomes. Various signaling pathways and factors have been identified as pivotal regulators of inflammation initiation and resolution.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Targeting macrophages in cancer immunotherapy

Zhaojun Duan et al.

Summary: Immunotherapy is considered the most promising treatment for cancers, with various strategies such as adoptive cellular immunotherapy, tumor vaccines, antibodies, immune checkpoint inhibitors, and small-molecule inhibitors showing success. The review highlights the role of macrophages in current immunotherapies and the potential benefits of targeting them, suggesting that therapeutic strategies involving macrophages have the potential to enhance the efficacy of cancer treatments.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Biochemistry & Molecular Biology

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Xiaonan Xiang et al.

Summary: Tumor-associated macrophages (TAMs) play a significant role in tumor immunotherapies, with potential therapeutic value in enhancing treatment outcomes.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Oncology

Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Chunxiao Li et al.

Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Immunology

Macrophage metabolic reprogramming during chronic lung disease

Patricia P. Ogger et al.

Summary: Airway macrophages are critical sentinels of lung homoeostasis and adapt their metabolic profile to fit their local niche during chronic lung diseases, using metabolic reprogramming for both host defence and potentially supporting chronic pathology. This understanding may lead to the development of AM-focused therapies.

MUCOSAL IMMUNOLOGY (2021)

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Article Rheumatology

Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon

Shuhong Han et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Review Immunology

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

Siyuan Chen et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

Xiang Zhang et al.

LABORATORY INVESTIGATION (2020)

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Article Biochemistry & Molecular Biology

Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization

Guolong Xu et al.

ONCOGENE (2020)

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Review Endocrinology & Metabolism

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

Matthieu Lacroix et al.

MOLECULAR METABOLISM (2020)

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Review Cell Biology

Targeting immunometabolism as an anti-inflammatory strategy

Eva M. Palsson-McDermott et al.

CELL RESEARCH (2020)

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Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells

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JOURNAL OF PROTEOME RESEARCH (2020)

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Review Medicine, Research & Experimental

Alternatively activated macrophages; a double-edged sword in allergic asthma

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Mitochondrial TCA cycle metabolites control physiology and disease

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Article Multidisciplinary Sciences

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

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Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis

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Toll-like Receptors from the Perspective of Cancer Treatment

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The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?

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The interplay of signaling pathway in endothelial cells-matrix stiffness dependency with targeted-therapeutic drugs

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

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Regulation of cGAS-Mediated Immune Responses and Immunotherapy

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The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity

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Bone Marrow-Derived and Elicited Peritoneal Macrophages Are Not Created Equal: The Questions Asked Dictate the Cell Type Used

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Kr?ppel-like factor 3 (KLF3) suppresses NF-?B?driven inflammation in mice

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Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer

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MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

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In vivo evidence for extracellular DNA trap formation

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CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling

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The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

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IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages

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Salmonella Interacts With Autophagy to Offense or Defense

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Alveolar Dynamics and Beyond - The Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis

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Review Immunology

Myeloid Cell-Derived Arginase in Cancer Immune Response

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The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

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Review Endocrinology & Metabolism

General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections

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Human chimeric antigen receptor macrophages for cancer immunotherapy

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Shedding New Light on Cancer Metabolism: A Metabolic Tightrope Between Life and Death

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Alveolar Macrophage Phenotype and Compartmentalization Drive Different Pulmonary Changes in Mouse Strains Exposed to Cigarette Smoke

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Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

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The Role of Danger Associated Molecular Patterns in Human Fetal Membrane Weakening

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Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19

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M2-Like Tumor-Associated Macrophage-Targeted Codelivery of STAT6 Inhibitor and IKKβ siRNA Induces M2-to-M1 Repolarization for Cancer Immunotherapy with Low Immune Side Effects

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ACS CENTRAL SCIENCE (2020)

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Article Cardiac & Cardiovascular Systems

Noncoding RNAs in Cardiovascular Disease: Current Knowledge, Tools and Technologies for Investigation, and Future Directions: A Scientific Statement From the American Heart Association

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Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma

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A review on the biology and properties of adipose tissue macrophages involved in adipose tissue physiological and pathophysiological processes

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LIPIDS IN HEALTH AND DISEASE (2020)

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Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells

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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

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Immunometabolism: new insights and lessons from antigen-directed cellular immune responses

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SEMINARS IN IMMUNOPATHOLOGY (2020)

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Overview of General and Discriminating Markers of Differential Microglia Phenotypes

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Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products

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Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system

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Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria

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Modulation of Cytokines and Extracellular Matrix Proteins Expression byLeishmania amazonensisin Susceptible and Resistant Mice

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Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches

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Interplay Between NLRP3 Inflammasome and Autophagy

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G-CSF and G-CSFR Induce a Pro-Tumorigenic Macrophage Phenotype to Promote Colon and Pancreas Tumor Growth

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Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs

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Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight

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Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

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Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Senescent cells and macrophages: key players for regeneration?

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Selective Uptake of Carboxylated Multi-Walled Carbon Nanotubes by Class A Type 1 Scavenger Receptors and Impaired Phagocytosis in Alveolar Macrophages

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NANOMATERIALS (2020)

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Review Immunology

Macrophages in Organ Transplantation

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FRONTIERS IN IMMUNOLOGY (2020)

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CD44 as a tumor biomarker and therapeutic target

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Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis

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Oleacein and Foam Cell Formation in Human Monocyte-Derived Macrophages: A Potential Strategy against Early and Advanced Atherosclerotic Lesions

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Review Immunology

GM-CSF: A Promising Target in Inflammation and Autoimmunity

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IMMUNOTARGETS AND THERAPY (2020)

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Targeting neutrophil extracellular traps in severe acute pancreatitis treatment

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THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2020)

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Letter Oncology

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions

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Review Nutrition & Dietetics

Vitamin D3 as Potential Treatment Adjuncts for COVID-19

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Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

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NATURE METABOLISM (2020)

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Review Oncology

Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001-2020)

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Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

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Molecular mechanisms and clinical management of cancer bone metastasis

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Metabolism of immune cells in cancer

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NATURE REVIEWS CANCER (2020)

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JOURNAL OF BIOMEDICAL SCIENCE (2020)

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A Cell-Specific Nuclear Factor-Kappa B-Activating Gene Expression Strategy for Delivering Cancer Immunotherapy

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HUMAN GENE THERAPY (2019)

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Breast Phyllodes Tumors Recruit and Repolarize Tumor-Associated Macrophages via Secreting CCL5 to Promote Malignant Progression, Which Can Be Inhibited by CCR5 Inhibition Therapy

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CLINICAL CANCER RESEARCH (2019)

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Review Cell Biology

Biophysical regulation of macrophages in health and disease

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JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Article Oncology

TNF-α derived from M2 tumor-associated macrophages promotes epithelial-mesenchymal transition and cancer sternness through the Wnt/β-catenin pathway in SMMC-7721 hepatocellular carcinoma cells

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EXPERIMENTAL CELL RESEARCH (2019)

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Article Oncology

CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

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EXPERIMENTAL CELL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

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MOLECULAR CANCER (2019)

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Article Neurosciences

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

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NATURE NEUROSCIENCE (2019)

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Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

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TRENDS IN IMMUNOLOGY (2019)

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Article Cell Biology

M2 macrophages promote NSCLC metastasis by upregulating CRYAB

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CELL DEATH & DISEASE (2019)

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Review Oncology

Interaction of tumor-associated macrophages and cancer chemotherapy

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ONCOIMMUNOLOGY (2019)

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Review Oncology

Metabolic reprogramming of macrophages during infections and cancer

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CANCER LETTERS (2019)

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Article Respiratory System

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

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EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Immunology

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

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IMMUNITY (2019)

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Review Immunology

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

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IMMUNITY (2019)

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Review Oncology

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Medicine, Research & Experimental

15-Deoxy-Δ-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

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PPAR RESEARCH (2019)

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Review Immunology

IL-1 Family Members in Cancer; Two Sides to Every Story

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FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review

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FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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IMMUNITY (2019)

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Article Medicine, General & Internal

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson et al.

EBIOMEDICINE (2019)

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Article Pharmacology & Pharmacy

Pexidartinib: First Approval

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DRUGS (2019)

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Article Medicine, Research & Experimental

Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment

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JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Multidisciplinary Sciences

Metabolic regulation of gene expression by histone lactylation

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NATURE (2019)

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Article Multidisciplinary Sciences

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

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JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)

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Review Biochemistry & Molecular Biology

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

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MOLECULAR CANCER (2019)

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Review Cell Biology

EMT Transition States during Tumor Progression and Metastasis

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TRENDS IN CELL BIOLOGY (2019)

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Review Immunology

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

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TRENDS IN IMMUNOLOGY (2019)

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Article Endocrinology & Metabolism

Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation

Gretchen L. Seim et al.

NATURE METABOLISM (2019)

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Review Biochemistry & Molecular Biology

Metabolic influence on macrophage polarization and pathogenesis

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BMB REPORTS (2019)

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Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

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NATURE REVIEWS IMMUNOLOGY (2019)

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Review Immunology

Immunometabolism at the interface between macrophages and pathogens

David G. Russell et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Oncology

Metabolic Regulation of Macrophage Polarization in Cancer

Kamiya Mehla et al.

TRENDS IN CANCER (2019)

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Review Immunology

Macrophage Extracellular Traps: A Scoping Review

Ryan S. Doster et al.

JOURNAL OF INNATE IMMUNITY (2018)

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Article Oncology

CCL26 Participates in the PRL-3-Induced Promotion of Colorectal Cancer Invasion by Stimulating Tumor-Associated Macrophage Infiltration

Qiusheng Lan et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Letter Rheumatology

Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis

Stefano Soldano et al.

ANNALS OF THE RHEUMATIC DISEASES (2018)

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Article Biochemistry & Molecular Biology

Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c

Yi Liu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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Article Biochemistry & Molecular Biology

LncRNA KCNQ1OT1 ameliorates particle-induced osteolysis through inducing macrophage polarization by inhibiting miR-21a-5p

Xuren Gao et al.

BIOLOGICAL CHEMISTRY (2018)

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Article Engineering, Biomedical

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

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BIOMATERIALS (2018)

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Article Biochemistry & Molecular Biology

Creatinine downregulates TNF-α in macrophage and T cell lines

Lisa A. Riesberg et al.

CYTOKINE (2018)

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Article Ophthalmology

WNT7A/B promote choroidal neovascularization

Joseph B. Lin et al.

EXPERIMENTAL EYE RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Deok-Hoon Kong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Oncology

Blocking Interleukin (IL)4-and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

Omar M. Rahal et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

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Review Cell Biology

Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

Maria G. Daskalaki et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Article Dermatology

Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin

Monique Hinchcliff et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Biochemistry & Molecular Biology

Silencing of H19 inhibits the adipogenesis and inflammation response in ox-LDL-treated Raw264.7 cells by up-regulating miR-130b

Yong Han et al.

MOLECULAR IMMUNOLOGY (2018)

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Article Medicine, General & Internal

Recurrent Glioblastoma Treated with Recombinant Poliovirus

Annick Desjardins et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Biochemistry & Molecular Biology

miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy

Jiajia Xi et al.

ONCOGENE (2018)

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Article Biochemistry & Molecular Biology

PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis

Yang Yang et al.

ONCOGENE (2018)

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Review Biotechnology & Applied Microbiology

Role of the NFκB-signaling pathway in cancer

Longzheng Xia et al.

ONCOTARGETS AND THERAPY (2018)

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Review Biotechnology & Applied Microbiology

Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial-mesenchymal transition

Yongxu Chen et al.

ONCOTARGETS AND THERAPY (2018)

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Article Multidisciplinary Sciences

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages

Jinglian Yan et al.

NATURE COMMUNICATIONS (2018)

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Article Pharmacology & Pharmacy

Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?

Serena Tedesco et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Plasma Cell Differentiation Pathways in Systemic Lupus erythematosus

Susan Malkiel et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Targeting Macrophages in Cancer: From Bench to Bedside

Ashleigh R. Poh et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Oncology

Tumor-associated macrophages secrete CCL2 and induce the invasive phenotype of human breast epithelial cells through upregulation of ERO1-alpha and MMP-9

Seungeun Lee et al.

CANCER LETTERS (2018)

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Article Oncology

Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer

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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Oncology

The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

Meng Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Targeting macrophages: therapeutic approaches in cancer

Luca Cassetta et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Article Oncology

A Single Institution Experience of Incorporation of Cisplatin into Adjuvant Chemotherapy for Patients With Triple-Negative Breast Cancer of Unknown BRCA Mutation Status

Ying-Wen Su et al.

CLINICAL MEDICINE INSIGHTS-ONCOLOGY (2018)

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Review Immunology

IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy

Lionel B. Ivashkiv

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Immunology

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Amira A. Barkal et al.

NATURE IMMUNOLOGY (2018)

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Review Immunology

Tumor-Associated Macrophages as Target for Antitumor Therapy

Katarzyna Sawa-Wejksza et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2018)

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Review Oncology

Epithelial-mesenchymal transition in tumor metastasis

Kay T. Yeung et al.

MOLECULAR ONCOLOGY (2017)

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Article Cell Biology

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

Birgit Ritschka et al.

GENES & DEVELOPMENT (2017)

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Article Medicine, Research & Experimental

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Shouyu Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Review Oncology

Tumor-associated macrophages: from basic research to clinical application

Li Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

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Article Immunology

Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1α and Repression of NF-κB

Jonathan Braverman et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Immunology

Cytoplasmic Form of Carlr lncRNA Facilitates Inflammatory Gene Expression upon NF-κB Activation

Ainara Castellanos-Rubio et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Immunology

Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis

Qinqin Pu et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Immunology

The NF-κB-Responsive Long Noncoding RNA FIRRE Regulates Posttranscriptional Regulation of Inflammatory Gene Expression through Interacting with hnRNPU

Yajing Lu et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

Lifang Cheng et al.

MOLECULAR THERAPY (2017)

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Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Multidisciplinary Sciences

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin et al.

SCIENCE (2017)

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Article Multidisciplinary Sciences

The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation

Meng Du et al.

NATURE COMMUNICATIONS (2017)

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Article Cardiac & Cardiovascular Systems

Deep RNA Sequencing Uncovers a Repertoire of Human Macrophage Long Intergenic Noncoding RNAs Modulated by Macrophage Activation and Associated With Cardiometabolic Diseases

Hanrui Zhang et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)

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Review Immunology

MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity

Jezrom Bokcaerin Self-Fordham et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Oncology

Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer

Alberto Malesci et al.

ONCOIMMUNOLOGY (2017)

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Article Oncology

Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression

Xiao-Long Fu et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

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Article Biochemistry & Molecular Biology

eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation

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BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2017)

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Review Cell Biology

Aging Aging and cancer: The role of macrophages and neutrophils

Connie Jackaman et al.

AGEING RESEARCH REVIEWS (2017)

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Substrate elasticity regulates the behavior of human monocyte-derived macrophages

Katrina M. Adlerz et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2016)

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Article Gastroenterology & Hepatology

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

Giuseppe Di Caro et al.

GUT (2016)

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Article Immunology

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis

Rachel G. Scheraga et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Oncology

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

Jason H. Stafford et al.

NEURO-ONCOLOGY (2016)

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Titanium surface characteristics, including topography and wettability, alter macrophage activation

Kelly M. Hotchkiss et al.

ACTA BIOMATERIALIA (2016)

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Review Oncology

CTLA-4 and PD-1 Pathways Similarities, Differences, and Implications of Their Inhibition

Elizabeth I. Buchbinder et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2016)

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Review Biochemistry & Molecular Biology

Epigenetic Regulation of Monocyte and Macrophage Function

Marten A. Hoeksema et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

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miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia

Silvia Nucera et al.

CANCER CELL (2016)

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Editorial Material Cell Biology

Inhibiting macrophage PI3Kγ to enhance immunotherapy

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CELL RESEARCH (2016)

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The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB

Gui Zhao et al.

FEBS LETTERS (2016)

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Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

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Article Engineering, Biomedical

Macrophage responses to 316L stainless steel and cobalt chromium alloys with different surface topographies

Jordan A. Anderson et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2016)

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Review Medicine, Research & Experimental

HIF1α and metabolic reprogramming in inflammation

Sarah E. Corcoran et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Medicine, Research & Experimental

Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer

Mingzhu Yin et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Medicine, Research & Experimental

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

Kipp Weiskopf et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Oncology

Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice

Lingxiang Kong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

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Article Immunology

KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation

W. A. Goodman et al.

MUCOSAL IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

Satoko Arai et al.

NATURE MEDICINE (2016)

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Review Pharmacology & Pharmacy

Bisphosphonates for cancer treatment: Mechanisms of action and lessons from clinical trials

Heleen. H. Van Acker et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Durable antitumor responses to CD47 blockade require adaptive immune stimulation

Jonathan T. Sockolosky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Biochemistry & Molecular Biology

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

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RNA BIOLOGY (2016)

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Article Multidisciplinary Sciences

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

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SCIENCE (2016)

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Review Biochemistry & Molecular Biology

Intermediates of Metabolism: From Bystanders to Signalling Molecules

Robert Haas et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages

Joseph A. Hollenbaugh et al.

VIROLOGY (2016)

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Article Multidisciplinary Sciences

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

Lesca M. Holdt et al.

NATURE COMMUNICATIONS (2016)

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Article Oncology

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

Xiang Ying et al.

ONCOTARGET (2016)

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Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles

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BIOMATERIALS SCIENCE (2016)

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Article Public, Environmental & Occupational Health

A Journey with Elie Metchnikoff: From Innate Cell Mechanisms in Infectious Diseases to Quantum Biology

Fabrice Merien

FRONTIERS IN PUBLIC HEALTH (2016)

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Review Immunology

A guide to immunometabolism for immunologists

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice

Federico Penas et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

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Article Oncology

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

Luiz Gustavo A. Chuffa et al.

BMC CANCER (2015)

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Review Oncology

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

S. J. Thomas et al.

BRITISH JOURNAL OF CANCER (2015)

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Article Oncology

Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma

Zhenyu Xiao et al.

CANCER LETTERS (2015)

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Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Russell Hughes et al.

CANCER RESEARCH (2015)

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Article Oncology

CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

Jemima Escamilla et al.

CANCER RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2

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FASEB JOURNAL (2015)

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Review Immunology

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system

Matthew C. Walsh et al.

IMMUNOLOGICAL REVIEWS (2015)

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Review Immunology

The interaction of anticancer therapies with tumor-associated macrophages

Alberto Mantovani et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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Article Immunology

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

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JOURNAL OF IMMUNOLOGY (2015)

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Review Cell Biology

Paradoxical changes in innate immunity in aging: recent progress and new directions

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JOURNAL OF LEUKOCYTE BIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques

Anusha N. Seneviratne et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

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Article Oncology

High Infiltration of Tumor-Associated Macrophages is Associated With a Poor Response to Chemotherapy and Poor Prognosis of Patients Undergoing Neoadjuvant Chemotherapy for Esophageal Cancer

Keijiro Sugimura et al.

JOURNAL OF SURGICAL ONCOLOGY (2015)

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Article Oncology

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

Eleanor I. Ager et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Review Multidisciplinary Sciences

Function and information content of DNA methylation

Dirk Schuebeler

NATURE (2015)

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Article Multidisciplinary Sciences

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

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NATURE (2015)

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Inflammation and cancer: advances and new agents

Shanthini M. Crusz et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

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Review Immunology

Molecular features of macrophage activation

Joachim L. Schultze et al.

SEMINARS IN IMMUNOLOGY (2015)

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Article Pharmacology & Pharmacy

AhR-dependent secretion of PDGF-BB by human classically activated macrophages exposed to DEP extracts stimulates lung fibroblast proliferation

Marie Jaguin et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

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Review Immunology

Macrophages and cancer: from mechanisms to therapeutic implications

Renato Ostuni et al.

TRENDS IN IMMUNOLOGY (2015)

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Article Oncology

Dequalinium blocks macrophage-induced metastasis following local radiation

Michael Timaner et al.

ONCOTARGET (2015)

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Article Cell Biology

TNF Counterbalances the Emergence of M2 Tumor Macrophages

Franz Kratochvill et al.

CELL REPORTS (2015)

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Article Oncology

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

Eleanor I. Ager et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)

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Review Immunology

Ontogeny of tissue-resident macrophages

Guillaume Hoeffel et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Medicine, General & Internal

Systemic sclerosis

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NATURE REVIEWS DISEASE PRIMERS (2015)

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Review Immunology

The evolution of our understanding of macrophages and translation of findings toward the clinic

Fernando O. Martinez et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2015)

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Article Immunology

MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway

Hangjie Ying et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Hematology

RP5-833A20.1/miR-382-5p/NFIA-Dependent Signal Transduction Pathway Contributes to the Regulation of Cholesterol Homeostasis and Inflammatory Reaction

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Article Immunology

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Abhishek K. Jha et al.

IMMUNITY (2015)

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Article Engineering, Biomedical

Integrin-directed modulation of macrophage responses to biomaterials

Toral D. Zaveri et al.

BIOMATERIALS (2014)

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Article Oncology

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Stephen Mok et al.

CANCER RESEARCH (2014)

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Article Medicine, Research & Experimental

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions

Marten A. Hoeksema et al.

EMBO MOLECULAR MEDICINE (2014)

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Article Endocrinology & Metabolism

Inhibiting DNA Methylation by 5-Aza-2′-deoxycytidine Ameliorates Atherosclerosis Through Suppressing Macrophage Inflammation

Qiang Cao et al.

ENDOCRINOLOGY (2014)

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Article Gastroenterology & Hepatology

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

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GASTROENTEROLOGY (2014)

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Review Immunology

Tumor-Associated Macrophages: From Mechanisms to Therapy

Roy Noy et al.

IMMUNITY (2014)

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Article Immunology

Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart

Phyllis-Jean Linton et al.

IMMUNOLOGY LETTERS (2014)

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Article Biochemistry & Molecular Biology

Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization

Dipali Date et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis

Yan-Wei Hu et al.

JOURNAL OF LIPID RESEARCH (2014)

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Article Endocrinology & Metabolism

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

Xiaosong Yang et al.

MOLECULAR ENDOCRINOLOGY (2014)

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Article Immunology

Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis

Sandra Bonne-Annee et al.

MICROBES AND INFECTION (2014)

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Review Nutrition & Dietetics

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

Bogna Grygiel-Gorniak

NUTRITION JOURNAL (2014)

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Article Multidisciplinary Sciences

Escherichia coli and Candida albicans Induced Macrophage Extracellular Trap-Like Structures with Limited Microbicidal Activity

Pan Liu et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL

Zhonghan Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Toxicology

SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages

Chang Cheng et al.

TOXICOLOGY LETTERS (2014)

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Article Multidisciplinary Sciences

Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

Nicholas E. Iiott et al.

NATURE COMMUNICATIONS (2014)

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Article Microbiology

Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages

Alexandra K. Marr et al.

PLOS PATHOGENS (2014)

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Article Biology

p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

Michal Krawczyk et al.

ELIFE (2014)

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Article Rheumatology

Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis

Romy B. Christmann et al.

ARTHRITIS & RHEUMATOLOGY (2014)

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Review Immunology

Molecular mechanisms that influence the macrophage M1-M2 polarization balance

Nan Wang et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Cell Biology

Aggravation of inflammatory response by costimulation with titanium particles and mechanical perturbations in osteoblast- and macrophage-like cells

Heon Goo Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)

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Article Hematology

Transcriptional Control of Macrophage Polarization

Derin Tugal et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Article Oncology

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

Giovanni Germano et al.

CANCER CELL (2013)

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Article Cell Biology

Effects of TiO2 nanotube layers on RAW 264.7 macrophage behaviour and bone morphogenetic protein-2 expression

S. J. Sun et al.

CELL PROLIFERATION (2013)

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Article Gastroenterology & Hepatology

Aging promotes the development of diet-induced murine steatohepatitis but not steatosis

Luis Fontana et al.

HEPATOLOGY (2013)

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Article Immunology

Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors

Diana L. Bonilla et al.

IMMUNITY (2013)

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Article Medicine, Research & Experimental

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

Rebecca S. Cook et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Review Immunology

TGF-β: Guardian of T Cell Function

Soyoung A. Oh et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Immunology

Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis

Ka-Wing Wong et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

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Article Dermatology

Local Arginase 1 Activity Is Required for Cutaneous Wound Healing

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Review Multidisciplinary Sciences

Macrophage biology in development, homeostasis and disease

Thomas A. Wynn et al.

NATURE (2013)

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Article Multidisciplinary Sciences

IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation

Tatyana Veremeyko et al.

PLOS ONE (2013)

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Review Immunology

MicroRNA-mediated control of macrophages and its implications for cancer

Mario Leonardo Squadrito et al.

TRENDS IN IMMUNOLOGY (2013)

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Article Engineering, Biomedical

Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres

Matthias Bartneck et al.

BIOMATERIALS (2012)

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Article Hematology

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

Ana M. Gil-Bernabe et al.

BLOOD (2012)

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Article Microbiology

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

Joseph E. Qualls et al.

CELL HOST & MICROBE (2012)

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Review Immunology

The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications

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CURRENT OPINION IN IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

LY294002 inhibits TLR3/4-mediated IFN-β production via inhibition of IRF3 activation with a PI3K-independent mechanism

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FEBS LETTERS (2012)

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Article Immunology

Mannheimia haemolytica and Its Leukotoxin Cause Macrophage Extracellular Trap Formation by Bovine Macrophages

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INFECTION AND IMMUNITY (2012)

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Article Oncology

Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer

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INTERNATIONAL JOURNAL OF CANCER (2012)

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Article Medicine, Research & Experimental

Macrophage plasticity and polarization: in vivo veritas

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JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Hematology

Shear stress is required for the endocytic uptake of the factor VIII-von Willebrand factor complex by macrophages

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JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)

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Article Biochemistry & Molecular Biology

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

Joshua D. Stender et al.

MOLECULAR CELL (2012)

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Article Multidisciplinary Sciences

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Sergei I. Grivennikov et al.

NATURE (2012)

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Article Multidisciplinary Sciences

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Laurens Kruidenier et al.

NATURE (2012)

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Review Oncology

Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

Annamaria Rapisarda et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

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Article Multidisciplinary Sciences

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Review Oncology

Cancer-related inflammation: Common themes and therapeutic opportunities

Frances R. Balkwill et al.

SEMINARS IN CANCER BIOLOGY (2012)

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Article Immunology

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

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FRONTIERS IN IMMUNOLOGY (2012)

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Article Oncology

Association of Intra-tumoral Infiltrating Macrophages and Regulatory T Cells Is an Independent Prognostic Factor in Gastric Cancer after Radical Resection

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ANNALS OF SURGICAL ONCOLOGY (2011)

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Article Cell Biology

Ketones and lactate increase cancer cell stemness, driving recurrence, metastasis and poor clinical outcome in breast cancer

Ubaldo E. Martinez-Outschoorn et al.

CELL CYCLE (2011)

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Article Cell Biology

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

Shannon E. Mullican et al.

GENES & DEVELOPMENT (2011)

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Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Tanaya Shree et al.

GENES & DEVELOPMENT (2011)

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Article Medicine, Research & Experimental

Kruppel-like factor 4 regulates macrophage polarization

Xudong Liao et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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Article Virology

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent FcγR Pathway

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JOURNAL OF VIROLOGY (2011)

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Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

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Article Immunology

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Thomas Krausgruber et al.

NATURE IMMUNOLOGY (2011)

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Article Oncology

Zoledronic Acid Reduces Bone Loss and Tumor Growth in an Orthotopic Xenograft Model of Osteolytic Oral Squamous Cell Carcinoma

Chelsea K. Martin et al.

CANCER RESEARCH (2010)

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Review Biochemistry & Molecular Biology

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov et al.

CELL (2010)

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Statins Enhance Formation of Phagocyte Extracellular Traps

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CELL HOST & MICROBE (2010)

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Article Oncology

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

Wei Zhang et al.

CLINICAL CANCER RESEARCH (2010)

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Article Cell Biology

Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis

Norihiko Takeda et al.

GENES & DEVELOPMENT (2010)

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Article Immunology

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

Attila Szanto et al.

IMMUNITY (2010)

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Article Biochemistry & Molecular Biology

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Sven Heinz et al.

MOLECULAR CELL (2010)

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Review Immunology

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Subhra K. Biswas et al.

NATURE IMMUNOLOGY (2010)

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Article Immunology

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

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NATURE IMMUNOLOGY (2010)

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Article Rheumatology

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

Nobuyo Higashi-Kuwata et al.

ARTHRITIS RESEARCH & THERAPY (2010)

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Review Immunology

Alternative Activation of Macrophages: An Immunologic Functional Perspective

Fernando O. Martinez et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

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Article Biochemistry & Molecular Biology

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Ravindra Majeti et al.

CELL (2009)

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Review Oncology

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

Bharat B. Aggarwal et al.

CLINICAL CANCER RESEARCH (2009)

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Article Multidisciplinary Sciences

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB

Chiara Porta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Hematology

Regulation of macrophage functions by PPAR-α, PPAR-γ, and LXRs in mice and men

Elena Rigamonti et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

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HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

Rose Du et al.

CANCER CELL (2008)

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Review Oncology

Interferon regulatory factor family of transcription factors and regulation of oncogenesis

Akinori Takaoka et al.

CANCER SCIENCE (2008)

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Article Cell Biology

Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance

Justin I. Odegaard et al.

CELL METABOLISM (2008)

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Review Geriatrics & Gerontology

Innate immunity and aging

Christian R. Gomez et al.

EXPERIMENTAL GERONTOLOGY (2008)

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Review Immunology

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

Xiaoyu Hu et al.

IMMUNOLOGICAL REVIEWS (2008)

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Article Biochemistry & Molecular Biology

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Shida Yousefi et al.

NATURE MEDICINE (2008)

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Phase 2 randomized trial of primary endocrine therapy versus chemotherapy in postmenopausal patients with estrogen receptor-positive breast cancer

Vladimir F. Semiglazov et al.

CANCER (2007)

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Article Engineering, Biomedical

The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production

Kai Soo Tan et al.

BIOMATERIALS (2006)

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Toll-like receptor signaling and IRF transcription factors

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IUBMB LIFE (2006)

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Article Engineering, Biomedical

Cyclic biaxial strain affects U937 macrophage-like morphology and enzymatic activities

LA Matheson et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2006)

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Article Multidisciplinary Sciences

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

RN Kaplan et al.

NATURE (2005)

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Article Multidisciplinary Sciences

Negative regulation of Toll-like-receptor signaling by IRF-4

H Negishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Neutrophil extracellular traps kill bacteria

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SCIENCE (2004)

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Article Medicine, Research & Experimental

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis

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JOURNAL OF CLINICAL INVESTIGATION (2004)

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Article Biochemistry & Molecular Biology

NF-KB and AP-1 connection:: Mechanism of NF-κB-Dependent regulation of AP-1 activity

S Fujioka et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

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Article Cell & Tissue Engineering

Monocytes and macrophages form branched cell columns in Matrigel: Implications for a role in Neovascularization

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STEM CELLS AND DEVELOPMENT (2004)

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Article Rheumatology

Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus

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ARTHRITIS AND RHEUMATISM (2003)

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Review Multidisciplinary Sciences

Inflammation and cancer

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NATURE (2002)

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Article Immunology

Aberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus

CG Katsiari et al.

CLINICAL IMMUNOLOGY (2002)

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Article Immunology

Cutting edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease

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JOURNAL OF IMMUNOLOGY (2002)

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Article Multidisciplinary Sciences

Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus

P Blanco et al.

SCIENCE (2001)

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Review Medicine, General & Internal

Inflammation and cancer: back to Virchow?

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LANCET (2001)

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Article Biochemistry & Molecular Biology

The p50-homodimer mechanism in tolerance to LPS

L Ziegler-Heitbrock

JOURNAL OF ENDOTOXIN RESEARCH (2001)

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