期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 7, 期 1, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a028373
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资金
- Novo Nordisk Foundation [16584]
- Canadian Institutes of Health Research (CIHR)
- European Molecular Biology Organization (EMBO)
- Cancer Research UK (TRACERx)
- Royal Society
- CRUK Lung Cancer Centre of Excellence
- Stand Up 2 Cancer (SU2C)
- Rose-trees Trust
- EU [259303]
- Prostate Cancer Foundation
- Breast Cancer Research Foundation
- European Research Council (THESEUS)
- National Institute for Health Research/University College London Hospitals Biomedical Research Centre
- Novo Nordisk Fonden [NNF15OC0016584] Funding Source: researchfish
Chromosomal aberrations during cell division represent one of the first recognized features of human cancer cells, and modern detection methods have revealed the pervasiveness of aneuploidy in cancer. The ongoing karyotypic changes brought about by chromosomal instability (CIN) contribute to tumor heterogeneity, drug resistance, and treatment failure. Whole-chromosome and segmental aneuploidies resulting from CIN have been proposed to allow macroevolutionary leaps that may contribute to profound phenotypic change. In this review, we will outline evidence indicating that aneuploidy and CIN contribute to cancer evolution.
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