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Article
Pediatrics
Rachael F. Kermond et al.
Summary: The study aimed to assess the immunologic response to SARS-CoV-2 mRNA vaccines in pediatric kidney transplant recipients aged 12-18. The results showed that the response rates were similar to adult kidney transplant recipients and improved with a third immunization. The choice of antimetabolite and prednisolone dosing influenced the rate of response.
PEDIATRIC NEPHROLOGY
(2023)
Article
Surgery
Xavier Charmetant et al.
Summary: Kidney transplant recipients (KTRs) have a reduced ability to produce adequate antibodies after receiving two doses of the COVID-19 mRNA vaccine. French health authorities have allowed a third booster dose for KTRs, but there is a lack of tools to determine their response. This study evaluates different factors to predict the response of KTRs to the booster dose, providing insights for personalized vaccination strategies.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Alexandra C. Walls et al.
Summary: Breakthrough infections induce more potent and durable antibody responses compared to those in unvaccinated individuals, providing better protection against spike mutations in variants. Multiple exposures to SARS-CoV-2 antigen enhance the quality of antibody responses. Developing vaccines with broad sarbecovirus immunity is crucial for pandemic preparedness.
Article
Urology & Nephrology
Louise Benning et al.
Summary: The antibody response after SARS-CoV-2 vaccination is impaired in kidney transplant recipients, especially against emerging variants like B.1.617.2 (d). Immunosuppressed patients show lower seroconversion rates and reduced neutralizing ability against different variants compared to healthy controls, indicating limited protection in the face of new strains.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Jinyan Liu et al.
Summary: This study demonstrates that cellular immunity induced by current SARS-CoV-2 vaccines is highly conserved to the Omicron spike protein. Individuals vaccinated with Ad26.COV2.S or BNT162b2 vaccines showed durable spike-specific CD8(+) and CD4(+) T cell responses that were cross-reactive to both the Delta and Omicron variants, including in central and effector memory cellular subpopulations.
Article
Cell Biology
Catherine Riou et al.
Summary: This study evaluated neutralizing antibody and T cell responses in patients infected with the Beta variant and those infected before its emergence. It found that CD4 and CD8 T cell responses to Beta were preserved overall, despite loss of recognition of immunogenic CD4 epitopes.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Maria Magicova et al.
Summary: The immune response to SARS-CoV-2 vaccination is impaired in kidney transplant recipients, especially in those who are SARS-CoV-2-naive. Factors such as mycophenolate use and prior depleting therapy contribute to the impaired humoral response. Survivors of COVID-19 and those vaccinated on the waiting list prior to transplantation exhibit a robust immune response to mRNA vaccines.
Letter
Surgery
Caroline X. Qin et al.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Pediatrics
Clarkson Crane et al.
Summary: The study found that the response to mRNA COVID-19 vaccines in adolescent kidney transplant recipients is lower compared to the general population but slightly better than in adult solid organ transplant patients. This supports the safety of vaccination in this population and suggests further research is needed to enhance vaccine effectiveness.
PEDIATRIC NEPHROLOGY
(2022)
Letter
Immunology
Luigi Cirillo et al.
Article
Medicine, General & Internal
Heba N. Altarawneh et al.
Summary: An analysis of data from Qatar showed that previous infection, vaccination, and hybrid immunity all demonstrated effectiveness in protecting against symptomatic Covid-19 caused by the BA.1 and BA.2 sublineages of the Omicron variant.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Surgery
Arne Sattler et al.
Summary: Protection against SARS-CoV2 is impaired in kidney transplant recipients due to low vaccine reactogenicity. After two doses of BNT162b2 vaccine, 90% of transplanted adolescents showed IgG seroconversion, but the response was significantly reduced compared to healthy controls. Spike-specific B cells were decreased and enriched for non-isotype-class-switched memory cells in patients. Although limitations in vaccine-specific immunity were identified, most adolescent patients showed robust humoral responses.
TRANSPLANT INTERNATIONAL
(2022)
Article
Surgery
Dafna Yahav et al.
Summary: The immune response to two doses of SARS-CoV-2 mRNA vaccine is limited among kidney transplant recipients. This study aimed to evaluate the humoral and cellular response to a third dose of the BNT162b2 vaccine. The results showed that the third dose improved the immune response among kidney transplant recipients, although 30% of them remained seronegative. Temporary reduction of immunosuppression before vaccination was found to improve the antibody response.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Olivia S. Kates et al.
Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Sophie Caillard et al.
Summary: Transplant recipients had a higher COVID-19-related mortality compared to nontransplant hospitalized patients but did not differ significantly in the rate of severe disease. Factors associated with severe COVID-19 included age, cardiovascular disease, dyspnea, fever, lymphopenia, and CRP.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Pediatrics
Matko Marlais et al.
Summary: This study examined the clinical course of COVID-19 in children with kidney disease who were taking immunosuppressive medication, finding that most of these children had mild cases of the disease. The study suggests that children on immunosuppressive therapy should not be isolated more strictly than those who are not receiving such treatment.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Letter
Urology & Nephrology
Antonio Mastrangelo et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Letter
Urology & Nephrology
Dominique Bertrand et al.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Shuo Feng et al.
Summary: Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine were identified as correlates of protection against symptomatic infection. Higher levels of immune markers were correlated with a reduced risk of symptomatic infection. The data can be used to extrapolate efficacy estimates to new populations.
Article
Public, Environmental & Occupational Health
Samantha M. Olson et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Letter
Medicine, General & Internal
Brian J. Boyarsky et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Hamad Ali et al.
Summary: Individuals with previous COVID-19 infection showed higher and more sustained levels of SARS-CoV-2 antibodies after COVID-19 vaccination compared to those without previous infection. Vaccinated individuals without previous COVID-19 infection experienced a faster decline in IgG and neutralizing antibodies compared to those with prior infection. Efforts should be made to prioritize vaccination for more individuals, especially those without previous COVID-19 infection, due to inconsistent vaccine supply globally.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Transplantation
Mario Fernandez-Ruiz et al.
Summary: Two-thirds of solid organ transplant recipients developed SARS-CoV-2-specific cell-mediated immunity following vaccination with mRNA-1273, which was lower than non-transplant controls. However, there was significant discordance between cell-mediated and neutralizing humoral immunities. Future studies should investigate the effectiveness of protection in patients with incomplete responses.
TRANSPLANTATION DIRECT
(2021)
Article
Medicine, General & Internal
Robert W. Frenck et al.
Summary: The BNT162b2 vaccine showed favorable safety profile and a greater immune response in 12-to-15-year-old recipients compared to young adults, and demonstrated high effectiveness against Covid-19.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Letter
Medicine, General & Internal
Nassim Kamar et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Letter
Immunology
Arnaud Devresse et al.
Letter
Pediatrics
Matko Marlais et al.
LANCET CHILD & ADOLESCENT HEALTH
(2020)
Article
Biotechnology & Applied Microbiology
Chee Wah Tan et al.
NATURE BIOTECHNOLOGY
(2020)
