期刊
JOURNAL OF NEUROSURGERY
卷 138, 期 3, 页码 750-759出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2022.6.JNS221103
关键词
severe symptomatic intracranial atherosclerosis; cerebral small vessel disease; symptomatic in-stent restenosis; vascular disorders
This study investigated the association between cerebral small vessel disease (CSVD) and in-stent restenosis (ISR) in patients with intracranial atherosclerotic stenosis (ICAS) after intracranial stenting. The results showed that patients with CSVD had a higher risk of ISR, especially those with deep white matter hyperintensities (DWMHs).
OBJECTIVE Cerebral small vessel disease (CSVD) commonly coexists with intracranial atherosclerotic stenosis (ICAS). In-stent restenosis (ISR) affects the nonprocedural outcome of severe symptomatic ICAS after intracranial stent-ing. However, only 8%-27% of ISR patients are symptomatic, which highlights the importance of the investigation of risk factors associated with symptomatic ISR (SISR) to improve long-term functional outcome. Whether CSVD is associated with SISR remains unclear. The authors tested the hypothesis that CSVD is associated with SISR in ICAS patients after intracranial stenting. METHODS This retrospective study enrolled 97 patients who were symptomatic due to severe anterior circulation ICAS treated with intracranial stenting. SISR was evaluated with clinical and vascular imaging follow-up. CSVD subtypes, in-cluding white matter hyperintensities (WMHs), enlarged perivascular spaces, and chronic lacunar infarctions, were evalu-ated. Cox regression analysis was used to compare the incidence of SISR between patients with and without CSVD.RESULTS Of the enrolled patients, 58.8% had CSVD. The 1-and 2-year ISR rates were 24.7% and 37.1%, respectively. Of the CSVD subtypes, SISR was associated with deep WMHs (DWMHs; HR 5.39, 95% CI 1.02-28.44). DWMH Faze-kas scale grades 2 (HR 85.54, 95% CI 2.42-3018.93) and 3 (HR 66.24, 95% CI 1.87-2352.32) were associated with SISR, but DWMH Fazekas grades 0 and 1 were not. The proportions of SISR in patients with DWMH Fazekas grades 0, 1, 2, and 3 were 16.7%, 33.3%, 50%, and 100%, respectively.CONCLUSIONS Patients with CSVD have a higher risk of SISR than those without CSVD. Of the CSVD subtypes, pa-tients with DWMHs are associated with SISR. The DWMH Fazekas scale score is considered to be a predictor for SISR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据