期刊
CHEMPLUSCHEM
卷 82, 期 2, 页码 251-260出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201600547
关键词
antiproliferation; benzodifurans; dynamic light scattering; nanoaggregates; UV/Vis spectroscopy
资金
- Italian Association for Cancer Research (AIRC) [17037]
- European Union's Horizon 2020 research and innovation programme (Marie Sklodowska-Curie) [642157]
- Marie Curie Actions (MSCA) [642157] Funding Source: Marie Curie Actions (MSCA)
To further explore the properties and bioactivity of benzodifurans, three compounds in this class were synthesised and characterised using spectroscopic and spectrometric techniques, as well as SEM and thermogravimetric analysis. The synthesised compounds showed interesting antiproliferative activity on different human cancer cells (HeLa, Hep-G2, WM266), whereas no relevant cytotoxic effect was observed on healthy control cells. To study the possible mechanism of action of the benzodifurans, their ability to bind various model DNA systems, their aggregation properties, and their ability to bind biologically relevant metal ions was evaluated. The molecules were found to form monodisperse nanoaggregates stable at physiological temperature, which are likely related to the observed bioactivity.
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