4.1 Article

Interaction of Biochemical Processes between Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Arterial Hypertension (PAH), and Coronavirus Disease 2019 (COVID-19)

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest

Damian Szklarczyk et al.

Summary: The STRING database systematically collects and integrates protein-protein interaction information, providing researchers with valuable insights into the functional and regulatory interactions within cells. It offers various data access and analysis tools.

NUCLEIC ACIDS RESEARCH (2023)

Article Cell Biology

COVID-19: advance in laboratory diagnostic strategy and technology

Kezhen Yi et al.

Summary: In summary, SARS-CoV-2, a beta-coronavirus with spike protein, can lead to inflammation and immune damage upon invading host cells. Rapid and accurate laboratory testing for SARS-CoV-2 is crucial for identifying and preventing COVID-19 transmission, while dynamic monitoring of organ function indicators is essential for evaluating therapeutic efficacy and prognosis for different clinical classifications of COVID-19 patients.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Article Medicine, General & Internal

Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology

Cristina Tudoran et al.

Summary: In COVID-19 infection, the risk associated with cardiovascular complications, PH, and RVD is significantly increased. Inflammatory factors are associated with the severity of pulmonary injury and the extent of PH and RVD.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Multidisciplinary Sciences

Efficacy and tolerability of bevacizumab in patients with severe Covid-19

Jiaojiao Pang et al.

Summary: In this single-arm clinical trial, the authors show that treatment of COVID-19 patients with bevacizumab, an anti-vascular endothelial growth factor drug, can improve PaO2/FiO(2) ratios and oxygen-support status. Relative to an external control group, bevacizumab shows clinical efficacy by improving oxygenation.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19

Jungchan Park et al.

Summary: The study found that the use of NSAIDs in Covid-19 patients was not associated with all-cause mortality or the need for ventilator care, indicating that NSAIDs can be safely used to alleviate symptoms in patients suspected of having Covid-19.

SCIENTIFIC REPORTS (2021)

Article Medical Informatics

Richer fusion network for breast cancer classification based on multimodal data

Rui Yan et al.

Summary: This study introduces a new approach for breast cancer classification based on multimodal data, integrating pathological images and structured EMR data to enhance accuracy. Experimental results demonstrate the method outperforms others in terms of average classification accuracy, with a dataset publicly available for download.

BMC MEDICAL INFORMATICS AND DECISION MAKING (2021)

Article Multidisciplinary Sciences

Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

Andrea R. Daamen et al.

Summary: Analysis of gene expression data from COVID-19 patients revealed that the inflammatory response is mainly driven by populations of myeloid-lineage cells. Delayed virus clearance may lead to exaggerated activation of these cells, contributing to disease pathogenesis through the production of inflammatory mediators.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19

Ki Kwang Oh et al.

Summary: This study explored the potential efficacy of NSAIDs against COVID-19 through network pharmacology, identifying 6MNA, Rofecoxib, and Indomethacin as promising candidates for inhibiting the RAS signaling pathway and alleviating excessive inflammation induced by SARS-CoV-2.

SCIENTIFIC REPORTS (2021)

Article Medicine, General & Internal

How Genetics Might Explain the Unusual Link Between Malaria and COVID-19

Marta Rusmini et al.

Summary: This study explores the possible inverse relationships between malaria and COVID-19, finding genetic variants that may play a role in both diseases. By analyzing public genome sequencing data, they identify meaningful variants in 6 genes that could provide insights for potential therapeutic options against COVID-19.

FRONTIERS IN MEDICINE (2021)

Article Urology & Nephrology

Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

Alieh Gholaminejad et al.

Summary: This study utilized the WGCNA algorithm to analyze a DN microarray dataset, identifying six co-expression modules with significant DEGs. Functional enrichment analyses and PPI network constructions revealed key biological processes and pathways such as metabolic processes, cell cycle control, and apoptosis. Hub genes, including FN1, SLC2A2, FABP1, EHHADH and PIPOX, were validated and a regulatory network involving upstream regulators such as mir-27a and REAL was constructed, providing new insights into DN pathogenesis.

BMC NEPHROLOGY (2021)

Editorial Material Biotechnology & Applied Microbiology

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

Guangdi Li et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

Letter Respiratory System

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19

Janice M. Leung et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Review Cardiac & Cardiovascular Systems

Cardiac involvement in COVID-19 patients: Risk factors, predictors, and complications: A review

Ghazal Aghagoli et al.

JOURNAL OF CARDIAC SURGERY (2020)

Article Medicine, Research & Experimental

Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD

Narjes Saheb Sharif-Askari et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Pediatrics

SARS-CoV-2 Infection and the Newborn

Fahri Ovali

FRONTIERS IN PEDIATRICS (2020)

Article Hematology

Platelet gene expression and function in patients with COVID-19

Bhanu Kanth Manne et al.

Article Cardiac & Cardiovascular Systems

Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China

Qing Deng et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

Review Pharmacology & Pharmacy

Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)

Surjeet Verma et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Medicine, General & Internal

The Efficacy of the Mineralcorticoid Receptor Antagonist Canrenone in COVID-19 Patients

Marco Vicenzi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples

Ling Leng et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

Fan Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Pharmacology & Pharmacy

Discovering drugs to treat coronavirus disease 2019 (COVID-19)

Liying Dong et al.

DRUG DISCOVERIES AND THERAPEUTICS (2020)

Review Immunology

Shared and Distinct Functions of Type I and Type III Interferons

Helen M. Lazear et al.

IMMUNITY (2019)

Article Medicine, Research & Experimental

Rho signaling pathway enhances proliferation of PASMCs by suppressing nuclear translocation of Smad1 in PAH

Hongwei Wei et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

Article Critical Care Medicine

AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension

Jiao Zhang et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Respiratory System

dentification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease

Lena Heinbockel et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2018)

Article Biochemical Research Methods

DSigDB: drug signatures database for gene set analysis

Minjae Yoo et al.

BIOINFORMATICS (2015)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Pharmacology & Pharmacy

p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD

Audreesh Banerjee et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

Article Medicine, General & Internal

The nature of small-airway obstruction in chronic obstructive pulmonary disease

JC Hogg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Biochemistry & Molecular Biology

Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema

RJ Kaner et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)