期刊
CELL REPORTS
卷 16, 期 3, 页码 717-730出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.06.024
关键词
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类别
资金
- Canadian Institutes of Health Research (CIHR) [119414, 132562, 142708]
- Canadian Diabetes Association (CDA) [OG-3-15-5014, CS-5-12-3886]
- NIH [HL075462]
- University of Toronto Banting and Best Diabetes Centre Sun Life New Investigator Award
- CDA Postdoctoral Fellowship
Obesity-related inflammation of metabolic tissues, including visceral adipose tissue (VAT) and liver, are key factors in the development of insulin resistance (IR), though many of the contributing mechanisms remain unclear. We show that nucleic-acid-targeting pathways downstream of extracellular trap (ET) formation, unmethylated CpG DNA, or ribonucleic acids drive inflammation in IR. High-fat diet (HFD)-fed mice show increased release of ETs in VAT, decreased systemic clearance of ETs, and increased autoantibodies against conserved nuclear antigens. In HFD-fed mice, this excess of nucleic acids and related protein antigens worsens metabolic parameters through a number of mechanisms, including activation of VAT macrophages and expansion of plasmacytoid dendritic cells (pDCs) in the liver. Consistently, HFD-fed mice lacking critical responders of nucleic acid pathways, Toll-like receptors (TLR)7 and TLR9, show reduced metabolic inflammation and improved glucose homeostasis. Treatment of HFD-fed mice with inhibitors of ET formation or a TLR7/9 antagonist improves metabolic disease. These findings reveal a pathogenic role for nucleic acid targeting as a driver of metabolic inflammation in IR.
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