Magnesium reabsorption in the kidney

Article Transplantation

Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia

Rosa Vargas-Poussou et al.

Summary: This study identifies TRPM7 as a potential candidate gene for hereditary HSH, and the mutations in TRPM7 gene result in impaired magnesium transport, leading to hypomagnesaemia and secondary hypocalcaemia.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

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Article Biochemistry & Molecular Biology

Transcriptional Control of Trpm6 by the Nuclear Receptor FXR

Eun Young Kim et al.

Summary: The FXR receptor is essential for liver function, bile acid synthesis, glucose metabolism, and enzyme activity. Research shows that FXR in intestinal epithelial cells is directly linked to the Mg2+ channel Trpm6, potentially connecting bile acid signaling to Mg2+ homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Urology & Nephrology

Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution

Tilman Breiderhoff et al.

Summary: Recent study indicates that claudin-10a is the major paracellular anion channel in the proximal tubule, and its deficiency leads to excessive reabsorption of calcium and magnesium. Various analyses, including electrophysiological studies, suggest compensatory transcellular transport in proximal and distal tubule segments, as well as metabolic adaptation in the proximal tubule, to counterbalance the loss of paracellular anion permeability.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Urology & Nephrology

Gitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA

Daan Viering et al.

Summary: This study found that mitochondrial DNA variants in the MT-TF and MT-TI genes can cause symptoms similar to Gitelman syndrome. Genetic investigation of mitochondrial DNA should be considered in patients with unexplained Gitelman syndrome-like tubulopathies.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Review Physiology

Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters

Lotte E. Tholen et al.

Summary: Hepatocyte nuclear factor 1 beta (HNF1 beta) is important for kidney development and function. Mutations in HNF1 beta can lead to autosomal dominant tubule interstitial kidney disease (ADTKD) subtype HNF1 beta, characterized by renal cysts, diabetes, genital tract malformations, and neurodevelopmental disorders. Electrolyte disturbances are common in ADTKD-HNF1 beta, but the underlying mechanisms are not fully understood.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2022)

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Article Pediatrics

Case Report: Recurrent Hemiplegic Migraine Attacks Accompanied by Intractable Hypomagnesemia Due to a de novo TRPM7 Gene Variant

Meifang Lei et al.

Summary: This study identified a novel variant of the TRPM7 gene in a patient with hemiplegic migraine attacks and hypomagnesemia. The findings highlight the importance of molecular genetic evaluation in patients with TRPM7 gene deficiency and demonstrate the causal relationship between TRPM7 gene variants and disease manifestations.

FRONTIERS IN PEDIATRICS (2022)

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Review Urology & Nephrology

The genetic spectrum of Gitelman(-like) syndromes

Karl P. Schlingmann et al.

Summary: Gitelman syndrome is a recessive salt-wasting disorder characterized by hypomagnesemia, hypokalemia, metabolic alkalosis and hypocalciuria. The majority of patients are explained by mutations and deletions in the SLC12A3 gene, and recent genetic studies have identified additional causes.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2022)

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Article Nutrition & Dietetics

Recommendation on an updated standardization of serum magnesium reference ranges

Andrea Rosanoff et al.

Summary: There is currently no international consensus on the normal range for serum magnesium levels. The wide variation in reference ranges used by different hospitals and laboratories highlights the need for standardization. Lowering the reference range to 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) is crucial for accurate diagnosis and management of magnesium status.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Multidisciplinary Sciences

FAM111A is dispensable for electrolyte homeostasis in mice

Barnabas P. Ilenwabor et al.

Summary: Autosomal dominant mutations in FAM111A cause Kenny-Caffey syndrome type 2, characterized by growth retardation and electrolyte imbalance. This study found that mice lacking the FAM111A gene maintained normal electrolyte balance on a standard diet.

SCIENTIFIC REPORTS (2022)

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Letter Nutrition & Dietetics

Comment to Recommendation on an updated standardization of serum magnesium reference ranges

Jeroen H. F. de Baaij et al.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Clinical Neurology

TARS2 variants causes combination oxidative phosphorylation deficiency-21: a case report and literature review

Xin Gao et al.

NEUROPEDIATRICS (2022)

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Article Multidisciplinary Sciences

Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells

Lisanne M. M. Gommers et al.

Summary: This study reveals that butyrate, as an endogenous substance, directly inhibits intestinal magnesium absorption. Furthermore, the inhibitory effect of butyrate on magnesium uptake is independent of metabolic regulation. This finding highlights the significance of microbial fermentation in the regulation of mineral absorption.

SCIENTIFIC REPORTS (2022)

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Article Endocrinology & Metabolism

Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes

Lynette J Oost et al.

ENDOCRINE REVIEWS (2022)

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Article Physiology

SLC41A1 knockout mice display normal magnesium homeostasis

Barnabas P. Ilenwabor et al.

Summary: SLC41A1 does not play a role in the regulation of systemic Mg2+ homeostasis in mice, and it does not compensate for the loss of SLC41A3.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2022)

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Article Urology & Nephrology

Sodium-Glucose Cotransporter 2 Inhibitors and Management of Refractory Hypomagnesemia Without Overt Urinary Magnesium Wasting: A Report of 2 Cases

Chintan Shah et al.

Summary: SGLT2 inhibitors have been found to improve serum magnesium levels in patients with refractory hypomagnesemia, even without significant urinary magnesium wasting, suggesting a potential role in altering magnesium homeostasis.

KIDNEY MEDICINE (2022)

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Article Urology & Nephrology

Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Serum Electrolyte Levels in Patients with Type 2 Diabetes: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials

Jingjing Zhang et al.

Summary: SGLT2 inhibitors significantly increase serum levels of magnesium and phosphate, consistent with a class effect of SGLT2 inhibition. However, further investigations are needed to assess the long-term efficacy and safety in patients with T2D with different clinical phenotypes.

KIDNEY360 (2022)

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Review Physiology

Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney

Gijs A. C. Franken et al.

Summary: This study describes three potential mechanisms by which Mg(2+)reabsorption in the distal convoluted tubule is linked to Na(+)reabsorption in patients with Na(+)wasting disorders. These mechanisms involve decreased NCC activity, common regulatory pathways of TRPM6 and NCC, and the impact of basolateral membrane potential on Na(+)and Mg(2+)extrusion. Advanced experimental models are needed to further study these molecular mechanisms.

ACTA PHYSIOLOGICA (2021)

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Article Biochemistry & Molecular Biology

FAM111A induces nuclear dysfunction in disease and viral restriction

Minghua Nie et al.

Summary: Mutations in the nuclear trypsin-like serine protease FAM111A cause Kenny-Caffey syndrome (KCS2) and perinatally lethal osteocraniostenosis (OCS), with FAM111A being identified as a restriction factor for certain host range mutants of SV40 and VACV. Research shows that FAM111A patient mutants are hyperactive and cytotoxic, inducing apoptosis-like phenotypes, while wild-type FAM111A activity causes similar nuclear phenotypes in restrictive cells. This study reveals a potentially unifying mechanism through which deregulated FAM111A activity restricts viral replication and causes KCS2 and OCS.

EMBO REPORTS (2021)

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Article Biochemistry & Molecular Biology

Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology

Judith A. Blake et al.

Summary: The Mouse Genome Database serves as a community model organism knowledge base for laboratory mice, providing authoritative biological reference data related to mouse genes, gene functions, phenotypes, and mouse models of human disease. It follows official guidelines for gene, allele, and mouse strain nomenclature and curates information from biomedical literature and datasets contributed by investigators. Major enhancements have been made to content and interfaces at MGD, including improvements in the Multi Genome Viewer, inclusion of more mouse strains, and integration of extensive data about mouse strain variants.

NUCLEIC ACIDS RESEARCH (2021)

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Article Physiology

Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC

Christina Schnoz et al.

Summary: Prox-1 is a transcription factor enriched in the DCT, which does not control DCT growth but contributes to the molecular control of DCT-dependent Mg2+ homeostasis in the adult kidney.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2021)

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Article Cell Biology

Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron

Alexander G. Marneros

Summary: The study reveals that deficiency of KCTD1 leads to dysregulation of magnesium and calcium homeostasis, resulting in hypomagnesemia and hypocalcemia, subsequently causing secondary hyperparathyroidism and progressive metabolic bone disease. This is driven by the reduced expression of key transport proteins in the kidneys, impacting urinary reabsorption of magnesium and calcium.

CELL REPORTS (2021)

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Article Urology & Nephrology

mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy

Karl P. Schlingmann et al.

Summary: Advances in genetic techniques have led to the identification of rare hereditary disorders of renal magnesium and salt handling over the last decade. A novel disease known as autosomal dominant kidney hypomagnesemia (ADKH-RRAGD) has been established, which combines an electrolyte-losing tubulopathy and dilated cardiomyopathy. Variants in the RRAGD gene were found to lead to an activation of mTOR signaling, indicating the critical role of Rag GTPase D in renal electrolyte handling and cardiac function.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Urology & Nephrology

Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis

Eszter Banki et al.

Summary: The study revealed the critical role of calcineurin in the function of the distal convoluted tubule (DCT), with the deletion of the relevant genes impacting the expression of specific proteins and signaling pathways in the DCT. The findings provide new insights into the pathophysiology of calcineurin inhibitor side effects and the molecular players involved in the DCT.

KIDNEY INTERNATIONAL (2021)

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Article Gastroenterology & Hepatology

Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH

Jorge Simon et al.

Summary: The study investigated the role of CNNM4 in the development of NASH by studying clinical samples and rodent models. It was found that CNNM4 is overexpressed in patients with NASH and plays a key role in magnesium transport in the liver. Silencing Cnnm4 can improve the pathophysiology of NASH.

JOURNAL OF HEPATOLOGY (2021)

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Article Urology & Nephrology

Targeted Single-Cell RNA-seq Identifies Minority Cell Types of Kidney Distal Nephron

Lihe Chen et al.

Summary: Single-cell transcriptomics analysis revealed unexpected diversity among the cells of the distal nephron in mice, identifying differences between DCT1 and DCT2 cells, as well as subtypes of CTAL cells.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Multidisciplinary Sciences

Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis

Megan R. Beggs et al.

Summary: Calcium homeostasis is maintained through coordination between intestinal absorption, renal reabsorption, and bone remodeling with tight-junction proteins called claudins playing a crucial role. Claudins-2 and -12 form independent Ca2+ permeable pores in renal and colonic epithelia, with either one sufficient to maintain Ca2+ balance. Deletion of both claudins leads to reduced intestinal Ca2+ absorption, higher urinary Ca2+ wasting, hypocalcemia, and reduced bone mineral density compared to single-null animals.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biochemistry & Molecular Biology

CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells

Zhiyong Bai et al.

Summary: Members of the CNNM family selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells. They also possess separate TRPM7-independent Mg2+ efflux activities that contribute to the control of cellular Mg2+ homeostasis. This study provides new insights into the mechanisms by which CNNMs regulate cellular magnesium levels.

PLOS BIOLOGY (2021)

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Article Biology

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

Astrid Kollewe et al.

Summary: TRPM7 is a membrane protein that plays a fundamental role in cellular uptake of divalent cations. The formation of high-molecular-weight complexes with CNNM1-4 and ARL15 impacts TRPM7 activity and opens new avenues towards understanding the cellular regulation and function of TRPM7 channels.

ELIFE (2021)

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Article Cell Biology

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski et al.

Summary: A novel mouse model carrying a human mutation at the intron-2 splice donor site exhibited renal cysts and phenotypes associated with reduced HNF1B levels, revealing the molecular mechanisms and pathological characteristics of developmental disease phenotypes caused by HNF1B deficiency.

DISEASE MODELS & MECHANISMS (2021)

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Article Biochemistry & Molecular Biology

Biallelic loss-of-function variants in KCNJ16 presenting with hypokalemic metabolic acidosis

Bryn D. Webb et al.

Summary: KCNJ16 encodes K(ir)5.1 which, together with K(ir)4.1, forms an important inwardly rectifying K+ channel in the basolateral membrane of epithelial cells. Loss-of-function variants in KCNJ16 can lead to chronic metabolic acidosis in patients, with exacerbations triggered by minor infections.

EUROPEAN JOURNAL OF HUMAN GENETICS (2021)

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Article Urology & Nephrology

Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness

Karl P. Schlingmann et al.

Summary: The study identified biallelic variants in the KCNJ16 gene in patients with a novel disease phenotype involving proximal and distal tubulopathy associated with deafness. The mutations affect the function of potassium channels in the kidney, leading to disturbances in kidney function. These variants also result in symptoms such as epilepsy, ataxia, and sensorineural deafness.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Multidisciplinary Sciences

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Yoshiharu Muto et al.

Summary: The integration of single cell transcriptome and chromatin accessibility datasets provides deeper insights into cell heterogeneity, demonstrating the potential of single nucleus ATAC-seq in the identification of cell identity and functional heterogeneity. Differentially accessible chromatin regions in promoters associated with differentially expressed genes suggest the involvement of transcription factors like NF-kappa B in driving transitions between cell subpopulations within the kidney. This multi-omics approach improves the detection of unique cell states and redefines cellular heterogeneity in specific regions of the kidney.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

Gijs A. C. Franken et al.

Summary: Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. The study reveals the important role of CNNM2 in embryonic development and Mg2+ homeostasis, as well as a previously undescribed role in the intestine, which may contribute to Mg2+ deficiency in mice and patients.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

Yevgen Zolotarov et al.

Summary: In this study, ARL15 was identified as a novel negative regulator of Mg2+ transport by promoting the complex N-glycosylation of CNNMs. The interaction between ARL15 and CNNM family members was found to be important for cellular localization in the kidney. Knockdown of ARL15 resulted in a significant increase in Mg-25(2+) uptake in multiple kidney cancer cell lines.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Article Endocrinology & Metabolism

Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes

Lynette J. Oost et al.

Summary: The study found that serum magnesium (Mg2+) concentration is inversely associated with the development of heart failure (HF) and atrial fibrillation (AF) as well as the occurrence of chronic kidney disease (CKD), diabetic retinopathy, and diabetic foot complications in type 2 diabetes patients. Additionally, glycemic control, as measured by hemoglobin A(1c) [HbA(1c)], partially mediated the association between serum Mg2+ and HF and microvascular complications.

DIABETES CARE (2021)

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Article Multidisciplinary Sciences

Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure

Yosuke Funato et al.

Summary: The study highlights the importance of renal TRPM6 in raising blood pressure by stimulating renin secretion, deficiency of TRPM6 leads to decreased blood pressure and disappearance of circadian variation, showing its crucial role in regulating blood pressure.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells

Chieko Hirota et al.

Summary: This study reveals the association between low serum magnesium ion levels and type 2 diabetes, and the impact of reactive oxygen species on magnesium channels and miRNA. The expression of magnesium channels and miRNA is influenced by H2O2, with an increase in miR-24-3p expression and a decrease in magnesium influx.

CELLS (2021)

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Article Physiology

Renal claudin-14 expression is not required for regulating Mg2+ balance in mice

Patricia G. Ferreira et al.

Summary: This study investigated the role of Mg2+ in regulating urinary excretion of Ca2+ and Mg2+ through the Ca2+-sensing receptor-claudin 14 (CLDN14) pathway using transgenic models and in vitro assays. The results suggest that CLDN14 is unlikely to play a significant role in the compensatory response to hypermagnesemia.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Article Transplantation

Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development

Christina Schnoz et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

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Article Pharmacology & Pharmacy

Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients

Hacene Bouras et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability

Allein Plain et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

Joshua N. Curry et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Physiology

Isoproterenol-Dependent Activation of TRPM7 Protects Against Neurotoxin-Induced Loss of Neuroblastoma Cells

Yuyang Sun et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Cell Biology

AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis

Alexander G. Marneros

DEVELOPMENTAL CELL (2020)

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Review Physiology

REGULATION OF THE RENAL NaCl COTRANSPORTER AND ITS ROLE IN POTASSIUM HOMEOSTASIS

Ewout J. Hoorn et al.

PHYSIOLOGICAL REVIEWS (2020)

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Article Physiology

Tacrolimus-induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurin

Brittany D. K. Gratreak et al.

PHYSIOLOGICAL REPORTS (2020)

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Article Urology & Nephrology

SGLT2 Inhibitors for Treatment of Refractory Hypomagnesemia: A Case Report of 3 Patients

Evan C. Ray et al.

KIDNEY MEDICINE (2020)

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Article Multidisciplinary Sciences

Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism

Serge Hardy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

Lorenz Mittermeier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice

Steef Kurstjens et al.

SCIENTIFIC REPORTS (2019)

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Article Endocrinology & Metabolism

Correction of hypomagnesemia by dapagliflozin in patients with type 2 diabetes: A post hoc analysis of 10 randomized, placebo-controlled trials

Robert D. Toto et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2019)

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Article Cell Biology

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

Andrew Ransick et al.

DEVELOPMENTAL CELL (2019)

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Article Endocrinology & Metabolism

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+

Steef Kurstjens et al.

DIABETOLOGIA (2019)

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Article Biochemistry & Molecular Biology

Tubular flow activates magnesium transport in the distal convoluted tubule

Eric H. J. Verschuren et al.

FASEB JOURNAL (2019)

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Article Biochemistry & Molecular Biology

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

Sebastian Koehler et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Physiology

SLC41A1 is essential for magnesium homeostasis in vivo

Francisco J. Arjona et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2019)

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Article Urology & Nephrology

HNF1B Mutations Are Associated With a Gitelman-like Tubulopathy That Develops During Childhood

Shazia Adalat et al.

KIDNEY INTERNATIONAL REPORTS (2019)

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Article Genetics & Heredity

Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome

Smail Hadj-Rabia et al.

GENETICS IN MEDICINE (2018)

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Article Urology & Nephrology

Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes

Tanguy Corre et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Article Biochemistry & Molecular Biology

Phosphatase of regenerating liver maintains cellular magnesium homeostasis

Atsushi Yoshida et al.

BIOCHEMICAL JOURNAL (2018)

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Article Medicine, Research & Experimental

MicroRNA-135a inhibits cardiac fibrosis induced by isoproterenol via TRPM7 channel

Yan Wu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Cell Biology

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis

Nils O. Lindstrom et al.

DEVELOPMENTAL CELL (2018)

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Editorial Material Neurosciences

CrossTalk proposal: CNNM proteins are Na+/Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption

Yosuke Funato et al.

JOURNAL OF PHYSIOLOGY-LONDON (2018)

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Editorial Material Neurosciences

CrossTalk opposing view: CNNM proteins are not Na+/Mg2+ exchangers but Mg2+ transport regulators playing a central role in transepithelial Mg2+ (re)absorption

Francisco J. Arjona et al.

JOURNAL OF PHYSIOLOGY-LONDON (2018)

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Article Urology & Nephrology

Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria

Tilman Breiderhoff et al.

KIDNEY INTERNATIONAL (2018)

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Article Biochemistry & Molecular Biology

Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)

Mingzhu Nie et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Genetics & Heredity

Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability

Karl P. Schlingmann et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2018)

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Article Cell Biology

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling

Turgay Saritas et al.

CELL REPORTS (2018)

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Article Physiology

Potassium conservation is impaired in mice with reduced renal expression of Kir4.1

Sundeep Malik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Urology & Nephrology

Hypermagnesuria in Humans Following Acute Intravenous Administration of Digoxin

Nabil Abu-Amer et al.

NEPHRON (2018)

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Article Urology & Nephrology

A de novo KCNA1 Mutation in a Patient with Tetany and Hypomagnesemia

Jenny van der Wijst et al.

NEPHRON (2018)

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Article Physiology

Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome

Wouter H. van Megen et al.

PHYSIOLOGICAL REPORTS (2018)

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Article Physiology

Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD

Eric H. J. Verschuren et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Endocrinology & Metabolism

Determinants of hypomagnesemia in patients with type 2 diabetes mellitus

Steef Kurstjens et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2017)

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Article Urology & Nephrology

The CIC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron

J. Christopher Hennings et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Review Physiology

Common variants in CLDN14 are associated with differential excretion of magnesium over calcium in urine

Tanguy Corre et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2017)

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Article Multidisciplinary Sciences

Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport

Susanne Milatz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Urology & Nephrology

A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations

Ernie M. H. F. Bongers et al.

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