期刊
CELL REPORTS
卷 15, 期 7, 页码 1597-1610出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.04.047
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资金
- Francis Crick Institute [FCI01]
- Cancer Research UK
- UK Medical Research Council
- Wellcome Trust
- European Research Council
- Worldwide Cancer Research
- Cancer Research UK [11567] Funding Source: researchfish
- The Francis Crick Institute [10166, 10008, 10002, 10168, 10011, 10490] Funding Source: researchfish
In order to facilitate the identification of factors and pathways in the cellular response to UV-induced DNA damage, several descriptive proteomic screens and a functional genomics screen were performed in parallel. Numerous factors could be identified with high confidence when the screen results were super-imposed and interpreted together, incorporating biological knowledge. Asearchable database, bioLOGIC, which provides access to relevant information about a protein or process of interest, was established to host the results and facilitate data mining. Besides uncovering roles in theDNA damage response for numerous proteins and complexes, including Integrator, Cohesin, PHF3, ASC-1, SCAF4, SCAF8, and SCAF11, we uncovered a role for the poorly studied, melanoma-associated serine/threonine kinase 19 (STK19). Besides effectively uncovering relevant factors, the multiomic approach also provides a systems-wide overview of the diverse cellular processes connected to the transcription-related DNA damage response.
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