期刊
CELL REPORTS
卷 16, 期 1, 页码 247-262出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.05.053
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资金
- CIHR [MOP 93761]
- NSERC of Canada [RGPIN 341543]
- NIH from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [R00 HD073239]
- National Institute of General Medical Sciences [R01 GM093301]
Steroid hormones are ancient signaling molecules found in vertebrates and insects alike. Both taxa show intriguing parallels with respect to how steroids function and how their synthesis is regulated. As such, insects are excellent models for studying universal aspects of steroid physiology. Here, we present a comprehensive genomic and genetic analysis of the principal steroid hormone-producing organs in two popular insect models, Drosophila and Bombyx. We identified 173 genes with previously unknown specific expression in steroid-producing cells, 15 of which had critical roles in development. The insect neuropeptide PTTH and its vertebrate counterpart ACTH both regulate steroid production, but molecular targets of these pathways remain poorly characterized. Identification of PTTH-dependent gene sets identified the nuclear receptor HR4 as a highly conserved target in both Drosophila and Bombyx. We consider this study to be a critical step toward understanding how steroid hormone production and release are regulated in all animal models.
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