期刊
CELL REPORTS
卷 17, 期 11, 页码 2811-2818出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.11.037
关键词
-
类别
资金
- Wellcome Trust [093053/Z/10/Z]
- Medical Research Council [G1001052]
- Cancer Research UK [C17199/A18246]
- Wellcome Trust [103865/Z/14/Z] Funding Source: Wellcome Trust
- MRC [G1001052, MR/J007439/1] Funding Source: UKRI
- Cancer Research UK [18246] Funding Source: researchfish
- Medical Research Council [MR/J007439/1, G1001052] Funding Source: researchfish
- Wellcome Trust [103865/Z/14/Z, 100326/Z/12/Z] Funding Source: researchfish
Adaptive immunity requires the generation of memory T cells from naive precursors selected in the thymus. The key intermediaries in this process are stem cell-like memory T (T-SCM) cells, multipotent progenitors that can both self-renew and replenish more differentiated subsets of memory T cells. In theory, antigen specificity within the T-SCM pool may be imprinted statically as a function of largely dormant cells and/or retained dynamically by more transitory subpopulations. To explore the origins of immunological memory, we measured the turnover of T-SCM cells in vivo using stable isotope labeling with heavy water. The data indicate that T-SCM cells in both young and elderly subjects are maintained by ongoing proliferation. In line with this finding, T-SCM cells displayed limited telomere length erosion coupled with high expression levels of active telomerase and Ki67. Collectively, these observations show that T-SCM cells exist in a state of perpetual flux throughout the human lifespan.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据