期刊
CELL REPORTS
卷 16, 期 3, 页码 631-643出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.06.020
关键词
-
类别
资金
- WKO grant
- Synergy ERC grant
- National Roadmap grant for Large-Scale Research Facilities of the Netherlands Organization for Scientific Research
- Dutch Cancer Society
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor, and no effective treatment is available to date. Mouse models of SCLC based on the inactivation of Rb1 and Trp53 show frequent amplifications of the Nfib and Mycl genes. Here, we report that, although overexpression of either transcription factor accelerates tumor growth, NFIB specifically promotes metastatic spread. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)negative invasive tumor cell population. Consistent with the mouse data, we find that NFIB is over-expressed in almost all tested human metastatic high-grade neuroendocrine lung tumors, warranting further assessment of NFIB as a tumor progression marker in a clinical setting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据