期刊
CELL REPORTS
卷 16, 期 9, 页码 2472-2485出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.07.076
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类别
资金
- National Blood Foundation
- American Society of Hematology
- NIH [R01 AI108829, 1R21AI110776-01]
- Canadian Institutes of Health Research
Evidence suggests that distinct splenic dendritic cell ( DC) subsets activate either CD4+ or CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen presentation; however, all DC subsets can activate both T cell lineages in vitro. Therefore, we tested whether the organization of DC and T cell subsets in the spleen dictated this preference. We discovered that CD4+ and CD8+ T cells segregated within splenic T cell zones prior to immunization. After intravenous immunization, the two major conventional DC populations, distinguished by 33D1 and XCR1 staining, migrated into separate regions of the T cell zone: 33D1+ DCs migrated into the CD4+ T cell area, whereas XCR1+ DCs migrated into the CD8+ T cell area. Thus, the post-immunization location of each DC subset correlated with the T cell lineage it preferentially primes. Preventing this co-localization selectively impaired either CD4+ or CD8+ T cell immunity to blood-borne antigens.
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