ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database

Chagas disease is a parasitical disease caused by Trypanosoma cruzi which affects similar to 7 million people worldwide. Per year, similar to 10 000 people die from this pathology. Indeed, similar to 30% of humans develop severe chronic forms, including cardiac, digestive or neurological disorders, for which there is still no treatment. In order to facilitate research on Chagas disease, a manual curation of all papers corresponding to 'Chagas disease' referenced on PubMed has been performed. All deregulated molecules in hosts (all mammals, humans, mice or others) following T. cruzi infection were retrieved and included in a database, named ChagasDB. A website has been developed to make this database accessible to all. In this article, we detail the construction of this database, its contents and how to use it.

Automated summary

Chagas disease is a parasitic disease caused by Trypanosoma cruzi, affecting approximately 7 million people worldwide. About 10,000 people die from this disease annually, with 30% developing severe chronic forms that currently have no treatment. To facilitate research on Chagas disease, a manual curation of all relevant papers on PubMed was conducted, and a database called ChagasDB was created to include all deregulated molecules in host organisms following T. cruzi infection. A website has also been developed for easy accessibility to this database, and this article provides detailed information on its construction, contents, and usage.