期刊
CELL REPORTS
卷 15, 期 7, 页码 1527-1541出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.04.023
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资金
- Leenaards Foundation, Lausanne, Switzerland
Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted to the postnatal period, we observed that the draining mesenteric lymph nodes (mLN) of helminth-infected mice form an extensive number of new, centrally located, B cell follicles in response to IL-4R alpha-dependent inflammation. IL-4R alpha signaling promoted LT alpha(1)beta(2) (lymphotoxin) expression by B cells, which then interacted with CCL19 positive stromal cells to promote lymphoid enlargement and the formation of germinal center containing B cell follicles. Importantly, de novo follicle formation functioned to promote both total and parasite-specific antibody production. These data reveal a role for type 2 inflammation in promoting stromal cell remodeling and de novo follicle formation by promoting B cell-stromal cell crosstalk.
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