期刊
CELL REPORTS
卷 16, 期 2, 页码 520-530出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.05.092
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资金
- NIH/National Institute on Aging [K99/R00, AG041765]
- Wisconsin Partnership Program
- Glenn Foundation Award for Research in the Biological Mechanisms of Aging
- UW-Madison School of Medicine and Public Health
- UW-Madison Department of Medicine
- American Federation for Aging Research
- Bakewell Foundation
- Longer Life Foundation (an RGA/Washington University Partnership)
- National Center for Research Resources [UL1 RR024992]
- American Diabetes Association [1-14-BS-115, 1-16-IBS-212, 1-16-PMF-001]
- NIH/NIDDK [R01 DK102598, K01 DK101683]
- UW Institute on Aging (NIA) [T32 AG000213]
- McArdle Departmental Funds
- Rural and Urban Scholars in Community Health Program
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.
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