期刊
CELL REPORTS
卷 14, 期 12, 页码 2925-2937出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.02.061
关键词
-
类别
资金
- Canadian Institutes of Health Research (CIHR)
- Fonds de Recherche du Quebec-Sante (FRQS)
- Canada Foundation for Innovation (CFI)
- Caldas fellowship (Colciencias)
How brain tumors progress from precancerous lesions to advanced cancers is not well understood. Using Ptch1(+/-) mice to study medulloblastoma progression, we found that Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell senescence in preneoplasia. In contrast, advanced tumors have evaded senescence. Remarkably, we discovered that the majority of advanced medulloblastomas display either spontaneous, somatic p53 mutations or Cdkn2a locus inactivation. Consistent with senescence evasion, these p53 mutations are always subsequent to Ptch1 LOH. Introduction of a p53 mutation prevents senescence, accelerates tumor formation, and increases medulloblastoma incidence. Altogether, our results show that evasion of senescence associated with Ptch1 LOH allows progression to advanced tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据