Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa

Letter Dermatology

Biomarkers of Tissue Turnover and Systemic Inflammation Are Associated with Disease Severity and Activity in Patients with Hidradenitis Suppurativa

Signe Holm Nielsen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2023)

Article Dermatology

Interleukin-17RA blockade by brodalumab decreases inflammatory pathways in hidradenitis suppurativa skin and serum

Kristina Navrazhina et al.

Summary: This study reveals that brodalumab, a human anti-IL-17 receptor A monoclonal antibody, effectively reduces inflammation and improves related pathways in Hidradenitis suppurativa (HS) patients. The response to treatment is best assessed in perilesional skin, and baseline expression levels of LCN2 and IL-17A can be used as predictive biomarkers for treatment response.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Review Allergy

Insights into hidradenitis suppurativa

Kelsey R. van Straalen et al.

Summary: Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects around 1% of the population and significantly impacts patients' quality of life. It is characterized by inflammatory lesions such as nodules, abscesses, and sinus tracts in areas like the armpits, groin, and buttocks, typically appearing during or after puberty. The development and maintenance of the disease involve a complex interplay of genetic predisposition, hormonal factors, obesity, and smoking. It is believed to stem from a defect in the hair follicle, leading to follicular plugging, cyst formation, and subsequent acute inflammation. Over time, acute lesions progress to a chronic condition with draining sinus tracts and extensive fibrosis. Hidradenitis suppurativa is associated with other immune-mediated inflammatory diseases, metabolic and cardiovascular disorders, and psychiatric comorbidities.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Immunology

Natural killer cells in antiviral immunity

Niklas K. Bjorkstrom et al.

Summary: This review explores the role of natural killer cells in acute and chronic viral infections, particularly focusing on insights from patients with primary immunodeficiencies. It also discusses the involvement of natural killer cells in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The review highlights the importance of NK cells in innate immune responses to viral infections and provides recent insights into their role in human studies.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Dysregulated CD38 Expression on Peripheral Blood Immune Cell Subsets in SLE

Marie Burns et al.

Summary: The study found significant increases in CD38 expression on multiple immune cells in SLE patients, with high correlation within individual patients but heterogeneity across the patient population. CD38 expression did not correlate with clinical activity index SLEDAI-2K or established serologic and immunological markers of disease activity in SLE.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Dermatology

Prevalence of Hidradenitis Suppurativa A Systematic Review and Meta-regression Analysis

Abdulhadi Jfri et al.

Summary: The prevalence of hidradenitis suppurativa (HS) was estimated to be 0.40% in the overall population, with clinical samples showing a higher prevalence (1.7%) compared to population-based studies (0.3%). These findings can aid in policy formulation and guiding principles for better disease diagnosis.

JAMA DERMATOLOGY (2021)

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Review Immunology