Cyclometalated platinum(II) complex as a selective light switch for G-quadruplex DNA

Cyclometalated 1,3-bis(8-quinolyl) phenyl chloroplatinum(ii) (Pt1) shows selective luminescence transduction of G-quadruplex binding over duplex DNA. The effect is enhanced on association with parallel and hybrid G-quadruplex structures over other topologies. The kinetics of binding are studied for c-myc and the response is found to be partially reversible in a displacement assay.

Automated summary

Pt1 selectively emits luminescence when binding to G-quadruplex rather than duplex DNA, with enhanced effect on parallel and hybrid G-quadruplex structures. The kinetics of binding are studied for c-myc and the response is partially reversible in a displacement assay.